The development of a novel transcatheter arterial infusion chemotherapy and significance of combination with molecular targeted agents
| Project/Area Number |
23591821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HIDAKA Isao 山口大学, 医学部附属病院, 助教 (70593440)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Takahiro 山口大学, 大学院医学系研究科, 教授 (00304478)
UCHIDA Koichi 山口大学, 医学部附属病院, 講師 (80397992)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝動注化学療法 / 肝細胞癌 / 微小デンプン球 / ミリプラチン / VEGF |
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| Research Abstract |
We designed a novel transcatheter arterial infusion chemotherapy as transvascular treatment for hepatocellular carcinoma, without the use of a solid embolic material, and the use of lipiodol and degradable starch microspheres (DSM). We investigated the efficancy of this therapy using cisplatin in clinical trial. In this study, we examined the usefulness of this new hepatic arterial infusion chemotherapy using miriplatin affinity with lipiodol better than cisplatin. In 2011, we start a prospective randomized study by two groups (DSM non-combination group, DSM combination group). So far, we treated in 30 cases. At the moment, progression-free survival tend to extended in DSM combination group, andresponse rate to be high in DSM combination group. We think this treatment is useful as a new hepatic arterial infusion chemotherapy.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2014
Author(s)
Junichi Zaitsu, Takahiro Yamasaki, Issei Saeki, Yohei Harima, Takuya Iwamoto, Yumiko Harima, Toshihiko Matsumoto, Yohei Urata, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Naoki Yamamoto, Seiji Kaino, Koichi Uchida, Shuji Terai, Isao Sakaida
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Journal Title
Hepatol Res
Volume: 44
Pages: 481-490
Related Report
Peer Reviewed
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[Journal Article] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease2013
Author(s)
Takashi Oono, Takahiro Yamasaki, Junichi Zaitsu, Issei Saeki, Takuya Iwamoto, Yumiko Harima, Yoshio Marumoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Makoto Segawa, Koichi Uchida, Shuji Terai, Ichiro Kunitugu, Tsuoshi Tanabe, Isao Sakaida
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Journal Title
Hepatol Res
Volume: (Epu ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma2012
Author(s)
Takahiro Yamasaki, Issei Saeki, Yohei Harima, Junichi Zaitsu, Masaki Maeda, Haruko Tanimoto, Takuya Iwamoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida
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Journal Title
J Gastroenterol
Volume: 47
Pages: 715-722
NAID
Related Report
Peer Reviewed
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