| Project/Area Number |
23591829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
SUGO Yumi 独立行政法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹 (90354836)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Shigeki 独立行政法人日本原子力研究開発機構, 原子力科学研究部門量子ビーム応用研究センター, 研究員 (10450305)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 放射性同位元素 / ポジトロン / Cu-64 / ペプチド / 分子プローブ / 環状ペプチド |
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| Research Abstract |
Technetium-99m (Tc-99m) is most commonly used as diagnostic radiopharmaceuticals. Tc-99m is generated by decay of molybdenum-99 (Mo-99), of which supply depends fully on the import from foreign countries. Recently, the supply shortage is the serious problem in the hospital.
Copper-64 (Cu-64) is a useful radionuclide in nuclear medicine, and can be produced by the cyclotron using (p,n) nuclear reaction from nickel-64 (Ni-64). In this study, we designed and synthesized some novel Cu-64 labeled agents for positron emission tomography (PET) imaging as an alternative to the Tc-99m radiopharmaceuticals.
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