Relationship between biomarker expression and lymph node metastasis in esophageal cancer: searching for an optimal radiation field

• Project/Area Number: 23591831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Yamagata University
• Principal Investigator: NEMOTO Kenji 山形大学, 医学部, 教授 (10208291)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 食道癌 / 放射線治療 / CTV / テーラーメード医療 / リンパ節転移 / 予防的放射線治療 / 免疫染色 / 化学放射線療法 / 照射野 / 個別化 / バイオマーカー / 標的体積 / 予防照射域

Outline of Final Research Achievements

In this study, we examined the relationships of biomarker expression with lymph node metastasis on esophageal cancer to determine in which cases a *preventive radiation field is redundant and in which cases an individually optimized radiation field can be used. (*Preventive radiation field was wide radiation field used to prevent lymph node metastasis.)
From this study, an increase in lysyl oxidase expression or CD44 expression on the cancer surface indicates the possibility of lymph node recurrence. Although it could be concluded whether a preventive radiation field should be set or not, there is a strong possibility of safe shrinkage or omission of the preventive radiation field if lysyl oxidase expression is not increased and it is confirmed that there is no CD44 expression. After this, we are aiming prospective study using individually optimized radiation field.

Research Products

• [Journal Article] Phase I/II trial of definitive carbon ion radiotherapy for prostate cancer: evaluation of shortening of treatment period to 3 weeks. (2014)
  • Author(s): Nomiya T, Tsuji H, Maruyama K, Toyama S, Suzuki H, Akakura K, Shimazaki J, Nemoto K, Kamada T, Tsujii H; Working Group for Genitourinary Tumors.
  • Journal Title: Br J Cancer. Volume: 110巻 Issue: 10 Pages: 2389-95
  • DOI: 10.1038/bjc.2014.191
  • Peer Reviewed
• [Journal Article] Status of radiotherapy in a multidisciplinary cancer board (2014)
  • Author(s): Ichikawa M, Nemoto K, Miwa M, Ohta I, Nomiya T, Yamakawa M, Itho Y, Fukui T, Yoshioka T
  • Journal Title: Journalof Radiation Research Volume: 55 Issue: 2 Pages: 305-308
  • DOI: 10.1093/jrr/rrt104
  • Peer Reviewed
• [Journal Article] Influence of a Multidisciplinary cancer board on treatment decisions. (2013)
  • Author(s): Nemoto K, Murakami M, Ichikawa M, Ohta I, Nomiya T, Yamakawa M, Ito Y, Fukui T, Yoshioka T
  • Journal Title: International Journal of Clinical Oncology Volume: 18 Issue: 4 Pages: 574-577
  • DOI: 10.1007/s10147-012-0420-x
  • Peer Reviewed
• [Journal Article] A newly introduced comprehensive consultation fee in the national health insurance system in Japan : a promotive effect of multidisciplinary medical care in the field of radiation oncology--results from a questionnaire survey (2013)
  • Author(s): Igaki H, Onishi H, Nakagawa K, Dokiya T, Nemoto K, Shigematsu N, Nishimura Y, Hiraoka M; Japanese Society for Therapeutic Radiology and Oncology Health Insurance Committee
  • Journal Title: Jpn J Clin Oncol Volume: 43(12) Issue: 12 Pages: 1233-7
  • DOI: 10.1093/jjco/hyt147
  • Peer Reviewed
• [Journal Article] Acute Radiation Esophagitis Caused by High-dose Involved Field Radiotherapy with Concurrent Cisplatin and Vinorelbine for Stage III Non-small Cell Lung Cancer. (2013)
  • Author(s): Kuroda Y, Sekine I, Sumi M, Sekii S, Takahashi K, Inaba K, Horinouchi H, Nokihara H, Yamamoto N, Kubota K, Murakami N, Morota M, Mayahara H, Ito Y, Tamura T, Nemoto K, Itami J.
  • Journal Title: Technol Cancer Res Treat Volume: 12 Issue: 4 Pages: 333-339
  • DOI: 10.7785/tcrt.2012.500319
  • Peer Reviewed
• [Journal Article] Long-term results of radiotherapy combined with nedaplatin and 5-fluorouracil for postoperative loco-regional recurrent esophageal cancer: update on a phase II study. (2012)
  • Author(s): Jingu K, Matsushita H, Takeda K, Umezawa R, Takahashi C, Sugawara T, Kubozono M, Abe K, Tanabe T, Shirata Y, Yamamoto T, Ishikawa Y, Nemoto K.
  • Journal Title: BMC Cancer Volume: 12 Issue: 1 Pages: 542-542
  • DOI: 10.1186/1471-2407-12-542
  • Peer Reviewed
• [Journal Article] Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report. (2012)
  • Author(s): Nomiya T
  • Journal Title: J Med Case Rep. Volume: 6 Issue: 1 Pages: 308-308
  • DOI: 10.1186/1752-1947-6-308
  • Peer Reviewed
• [Journal Article] Radiotherapy for esophageal cancer in Japan. (2012)
  • Author(s): Yamada S, Nemoto K, Ariga H, Jingu K.
  • Journal Title: Esophagus Volume: 9 Issue: 2 Pages: 66-74
  • DOI: 10.1007/s10388-012-0321-0
  • Peer Reviewed
• [Journal Article] Concurrent Radiotherapy and Gemcitabine for Unresectable Pancreatic Adenocarcinoma : Impact of Adjuvant Chemotherapy on Survival (2011)
  • Author(s): Ogawa K, Ito Y, Hirokawa N, Onishi H, Karasawa K, Nemoto K, Nishimura Y., et al
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: (ahead of print) Issue: 2 Pages: 559-565
  • DOI: 10.1016/j.ijrobp.2011.07.013
  • Peer Reviewed
• [Journal Article] Gastrointestinal Cancers. Intraoperative radiotherapy for unresectable pancreatic cancer: a multi-institutional retrospective analysis of 144 patients (2011)
  • Author(s): Ogawa K, Karasawa K, Ito Y, Ogawa Y, Jingu K, Onishi H, Aoki S, Wada H, Kokubo M, Ogo E, Etoh H, Kazumoto T, Takayama M, Nemoto K, Nishimura Y
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 80 Issue: 1 Pages: 1111-1118
  • DOI: 10.1016/j.ijrobp.2010.01.065
  • Peer Reviewed
• [Journal Article] Long-term results of radiochemotherapy for solitary lymph node metastasis after curative resection of esophageal cancer (2011)
  • Author(s): Jingu K, Ariga H, Nemoto K, Narazaki K, Umezawa R, Takeda K, Koto M, Kubozono M, Yamada S
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 83(1) Issue: 1 Pages: 172-177
  • DOI: 10.1016/j.ijrobp.2011.06.1978
  • Peer Reviewed
• [Presentation] 食道癌 (2014)
  • Author(s): 根本建二
  • Organizer: JDDW 2014 第22回日本消化器関連学会週間
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-10-24
  • Invited
• [Presentation] 日本の放射線腫瘍医教育. (2014)
  • Author(s): 根本建二
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-11
  • Invited
• [Presentation] 放射線治療中の診察頻度に関する意識調査 (2012)
  • Author(s): 根本建二
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: 東京国際フォーラム（東京）
• [Presentation] 転移性脳腫瘍に対する放射線治療の展望 (2012)
  • Author(s): 根本建二
  • Organizer: 日本癌治療学会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Invited
• [Presentation] 化学放射線療法の新展開-食道癌- (2011)
  • Author(s): 根本建二
  • Organizer: 日本臨床腫瘍学会(招待講演)
  • Place of Presentation: 横浜 パシフィコ横浜
• [Presentation] 放射線による緩和医療 (2011)
  • Author(s): 根本建二
  • Organizer: 日本緩和医療学会(招待講演)
  • Place of Presentation: 札幌 さっぽろ芸術文化の館
• [Presentation] 地域がんネットワークの役割 (2011)
  • Author(s): 根本建二
  • Organizer: 日本放射線腫瘍学会(招待講演)
  • Place of Presentation: 神戸 ポートピアホテル