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High precision radiotherapy considering the risk of recurrence and complication for cervical cancer

Research Project

Project/Area Number 23591833
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

OHNO Tatsuya  群馬大学, 重粒子線医学推進機構, 教授 (10344061)

Co-Investigator(Kenkyū-buntansha) KATO Shingo  埼玉医科大学, 医学部, 教授 (00370875)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords子宮頸癌 / 放射線治療 / 重粒子線治療 / 再発リスク / 画像誘導下 / 小線源治療 / 婦人科腫瘍 / 高精度放射線治療
Research Abstract

The purpose of the study was to develop high precision radiotherapy considering the risk of recurrence and complication and to promote the personalized treatment for uterine cervical cancer. The major research included image-guided brachytherapy (IGBT) for primary tumor, control of pelvic lymph node metastases, and comparison of intensity-modulated radiotherapy (IMRT) with conventional 3D conformal radiotherapy.
In the IGBT, increasing or decreasing of point A dose balanced sufficient dose between rectum and target. In case of irregular-shaped bulky tumor, hybrid brachytherapy consisting of conventional application and interstitial needle was effective to cover the tumor with sufficient dose while sparing the rectal dose. We also clarified the pelvic control dose and the sparing effect of small intestine and pelvic bone doses by IMRT.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (47 results)

All 2014 2013 2012 2011 Other

All Journal Article (29 results) (of which Peer Reviewed: 26 results) Presentation (13 results) (of which Invited: 4 results) Book (5 results)

  • [Journal Article] Impact of boost irradiation on pelvic lymph node control in patients with cervical cancer2014

    • Author(s)
      Wakatsuki M, Ohno T, Kato S, Ando K, Noda SE, Kiyohara H, Shibuya K, Karasawa K, Kamada T, Nakano T
    • Journal Title

      J Radiat Res

      Volume: 55 Pages: 139-45

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbon-ion radiotherapy for marginal lymph node recurrences of cervical cancer after definitive radiotherapy : a case report2013

    • Author(s)
      Tamaki T, Ohno T, Kiyohara H, Noda SE, Ohkubo Y, Ando K, Wakatsuki M, Kato S, Kamada T, Nakano T
    • Journal Title

      Radiat Oncol

      Volume: 5 Pages: 79-79

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of hematological toxicities between innovator and generic cisplatin formulations in cervical cancer patients treated with concurrent chemoradiotherapy2013

    • Author(s)
      Oike T, Ohno T, Noda SE, Sato H, Tamaki T, Kiyohara H, Ando K, Nakano T
    • Journal Title

      J Radiat Res

      Volume: 54 Pages: 474-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer2013

    • Author(s)
      Ohkubo Y, Ohno T, Noda SE, Kubo N, Nakagawa A, Kawahara M, Abe T, Kiyohara H, Wakatsuki M, Nakano T
    • Journal Title

      J Radiat Res

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution patterns of metastatic pelvic lymph nodes assessed by CT/MRI in patients with uterine cervical cancer2013

    • Author(s)
      Kasuya G, Toita T, Furutani K, Kodaira T, Ohno T, Kaneyasu Y, Yoshimura R, Uno T, Yogi A, Ishikura S, Hiraoka M
    • Journal Title

      Radiat Oncol

      Volume: 8 Pages: 139-139

    • NAID

      120006937790

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term Follow-up Results of a Multi-institutional Phase 2 Study of Concurrent Chemoradiation Therapy for Locally Advanced Cervical Cancer in East and Southeast Asia2013

    • Author(s)
      Kato S, Ohno T, Thephamongkhol K, Chansilpa Y, Cao J, Xu X, Devi CR, Swee TT, Calaguas MJ, de Los Reyes RH, Cho CK, Dung TA, Supriana N, Erawati D, Mizuno H, Nakano
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 87 Pages: 100-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of boost irradiation on pelvic lymph node control in patients with cervical cancer.2013

    • Author(s)
      Wakatsuki M, Ohno T, Kato S, Ando K, Noda SE, Kiyohara H, Shibuya K, Karasawa K, Kamada T, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 55 Issue: 1 Pages: 139-145

    • DOI

      10.1093/jrr/rrt097

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon-ion radiotherapy for marginal lymph node recurrences of cervical cancer after definitive radiotherapy: a case report.2013

    • Author(s)
      Tamaki T, Ohno T, Kiyohara H, Noda SE, Ohkubo Y, Ando K, Wakatsuki M, Kato S, Kamada T, Nakano T.
    • Journal Title

      Radiat Oncol.

      Volume: 5 Pages: 79-79

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of hematological toxicities between innovator and generic cisplatin formulations in cervical cancer patients treated with concurrent chemoradiotherapy.2013

    • Author(s)
      Oike T, Ohno T, Noda SE, Sato H, Tamaki T, Kiyohara H, Ando K, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 54 Issue: 3 Pages: 474-478

    • DOI

      10.1093/jrr/rrs121

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer.2013

    • Author(s)
      Ohkubo Y, Ohno T, Noda SE, Kubo N, Nakagawa A, Kawahara M, Abe T, Kiyohara H, Wakatsuki M, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 54 Issue: 6 Pages: 1138-1145

    • DOI

      10.1093/jrr/rrt073

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term Follow-up Results of a Multi-institutional Phase 2 Study of Concurrent Chemoradiation Therapy for Locally Advanced Cervical Cancer in East and Southeast Asia.2013

    • Author(s)
      Kato S, Ohno T, Thephamongkhol K, Chansilpa Y, Cao J, Xu X, Devi CR, Swee TT, Calaguas MJ, de Los Reyes RH, Cho CK, Dung TA, Supriana N, Erawati D, Mizuno H, Nakano.
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 87 Issue: 1 Pages: 100-105

    • DOI

      10.1016/j.ijrobp.2013.04.053

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insufficiency fractures after pelvic radiation therapy for uterine cervical cancer : an analysis of subjects in a prospective multi-institutional trial, and cooperative study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)2012

    • Author(s)
      Tokumaru S, Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Yamauchi C, Suzuki O, Sakurai H, Teshima T, Kagami Y, Nakano T, Hiraoka M, Mitsuhashi N, Kudo S
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 84

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 子宮頸癌に対するイメージベース小線源治療の展望2012

    • Author(s)
      大野達也、野田真永、久保亘輝、中川彰子、渋谷圭、清原浩樹、斉藤淳一、鈴木義行、中野隆史
    • Journal Title

      臨床放射線

      Volume: 57 Pages: 502-9

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
  • [Journal Article] Insufficiency fractures after pelvic radiation therapy for uterine cervical cancer: an analysis of subjects in a prospective multi-institutional trial, and cooperative study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG).2012

    • Author(s)
      Tokumaru S, Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kazumoto T, et al
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 84

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective multi-institutional study of definitive radiotherapy with high-dose-rate intracavitary brachytherapy in patients with nonbulky (<4-cm) stage I and II uterine cervical cancer (JAROG0401/JROSG04-2).2012

    • Author(s)
      Toita T, Kato S, Niibe Y, Ohno T, Kazumoto T, Kodaira T, Kataoka M, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 82

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective multi-institutional study of definitive radiotherapy with high-dose-rate intracavitary brachytherapy in patients with nonbulky (<4-cm) stage I and II uterine cervical cancer (JAROG0401/JROSG04-2).2012

    • Author(s)
      Toita T, Kato S, Niibe Y, Ohno T, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Tokumaru S, Yamauchi C, Suzuki O, Sakurai H, Numasaki H, Teshima T, Oguchi M, Kagami Y
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 82

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] JCOG Radiation Therapy Study Group. A consensus-based guideline defining clinical target volume for primary disease in external beam radiotherapy for intact uterine cervical cancer2011

    • Author(s)
      Toita T, Ohno T, Kaneyasu Y, Kato T, Uno T, Hatano K, Norihisa Y, Kasamatsu T, Kodaira T, Yoshimura R, Ishikura S, Hiraoka M
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41 Pages: 1119-26

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dose volume analysis of radiotherapy for inoperable patients with stage I-II endometrial carcinoma2011

    • Author(s)
      Ohkubo Y, Kato S, Kiyohara H, Tsuruoka I, Tamaki T, Noda SE, Ohno T, Nakano T
    • Journal Title

      J Radiat Res

      Volume: 52 Pages: 666-73

    • NAID

      10029456132

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy2011

    • Author(s)
      Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa K, Moritake T, Michikawa Y, Iwakawa M, Imai T
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 81 Pages: 1144-52

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma2011

    • Author(s)
      Saitoh J, Ohno T, Sakurai H, Katoh H, Wakatsuki M, Noda SE, Suzuki Y, Sibuya K, Takahashi T, Nakano T
    • Journal Title

      J Radiat Res

      Volume: 52 Pages: 490-5

    • NAID

      10029122290

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracavitary combined with CT-guided interstitial brachytherapy for locally advanced uterine cervical cancer : introduction of the technique and a case presentation2011

    • Author(s)
      Wakatsuki M, Ohno T, Yoshida D, Noda SE, Saitoh J, Shibuya K, Katoh H, Suzuki Y, Takahashi T, Nakano T
    • Journal Title

      J Radiat Res

      Volume: 52 Pages: 54-8

    • NAID

      10027418268

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 子宮頸癌に対するIMRT治療計画2011

    • Author(s)
      大野達也、河村英将、野田真永、中島聖、板橋祐典、中野隆史
    • Journal Title

      臨床放射線

      Volume: 56 Pages: 1609-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] Expression of hypoxia-inducible factor 1α predicts clinical outcome after preoperative hyperthermo-chemoradiotherapy for locally advanced rectal cancer.2011

    • Author(s)
      Shioya M, Takahashi T, Ishikawa H, Sakurai H, Ebara T, Suzuki Y, Saitoh J, Ohno T, Asao T, Kuwano H, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 52 Pages: 821-827

    • NAID

      10029653265

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blood flow change quantification in cervical cancer before and during radiation therapy using perfusion CT.2011

    • Author(s)
      hibuya K, Tsushima Y, Horisoko E, Noda SE, Taketomi-Takahashi A, Ohno T, Amanuma M, Endo K, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 52 Pages: 804-811

    • NAID

      10029653202

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A consensus-based guideline defining clinical target volume for primary disease in external beam radiotherapy for intact uterine cervical cancer.2011

    • Author(s)
      Toita T, Ohno T, Kaneyasu Y, Kato T, Uno T, Hatano K, Norihisa Y, Kasamatsu T, Kodaira T, Yoshimura R, Ishikura S, Hiraoka M
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 41 Pages: 1119-1126

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dose volume analysis of radiotherapy for inoperable patients with stage I-II endometrial carcinoma.2011

    • Author(s)
      Ohkubo Y, Kato S, Kiyohara H, Tsuruoka I, Tamaki T, Noda SE, Ohno T, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 52 Pages: 666-673

    • NAID

      10029456132

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma.2011

    • Author(s)
      Saitoh J, Ohno T, Sakurai H, Katoh H, Wakatsuki M, Noda SE, Suzuki Y, Sibuya K, Takahashi T, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 52 Pages: 490-495

    • NAID

      10029122290

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy.2011

    • Author(s)
      Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa K, Moritake T, Michikawa Y, Iwakawa M, Imai T.
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 81 Pages: 1144-1152

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 子宮頸癌に対するIMRT治療計画2011

    • Author(s)
      大野達也、河村英将、野田真永、中島聖、板橋佑典、中野隆史
    • Journal Title

      臨床放射線

      Volume: 56 Pages: 1609-1613

    • Related Report
      2011 Research-status Report
  • [Presentation] 子宮頸癌腔内照射に対する画像誘導3次元治療計画の国内実態調査2013

    • Author(s)
      大野達也、戸板孝文、辻野佳世子、内田伸恵、幡野和男、西村哲夫、石倉聡
    • Organizer
      日本放射線腫瘍学会第26回学術大会要望演題
    • Place of Presentation
      青森
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮頸癌に対するBrachytherapy:2Dから3Dへ2013

    • Author(s)
      大野達也、野田真永、田巻倫明、尾池貴洋、安藤謙、清原浩樹、高草木陽介、渋谷圭、中野隆史
    • Organizer
      小線源治療部会第15回学術大会
    • Place of Presentation
      福岡 (ワークショップ)
    • Year and Date
      2013-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮頸癌に対するImage-guided brachytherapy〜群馬大学の取組み〜2012

    • Author(s)
      大野達也
    • Organizer
      第60回中国四国放射線治療懇話会
    • Place of Presentation
      岡山 (特別講演)
    • Year and Date
      2012-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 婦人科腫瘍に対するImage-guided brachytherapy2012

    • Author(s)
      大野達也
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜 (教育講演)
    • Year and Date
      2012-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮頸癌に対するImage-guided brachytherapy~群馬大学の取組み~2012

    • Author(s)
      大野達也
    • Organizer
      第60回中国四国放射線治療懇話会
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 婦人科腫瘍に対するImage-guided brachytherapy2012

    • Author(s)
      大野達也、
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 子宮頸癌に対するIn-room CT-guided brachytherapy2011

    • Author(s)
      大野達也
    • Organizer
      日本放射線腫瘍学会第24回学術大会
    • Place of Presentation
      神戸 (シンポジウム)
    • Year and Date
      2011-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 小線源治療の均てん化治療手技の教育(子宮)2011

    • Author(s)
      大野達也
    • Organizer
      小線源治療部会第13回研究会
    • Place of Presentation
      沖縄 (ワークショップ)
    • Year and Date
      2011-05-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 群馬大学医学部附属病院における重粒子線がん治療2011

    • Author(s)
      大野達也、中野隆史、金井達明
    • Organizer
      日本放射線腫瘍学会第24回学術大会 シンポジウム(招待講演)
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児がんに対する粒子線治療:陽子線と炭素線.2011

    • Author(s)
      大野達也
    • Organizer
      第53回日本小児血液・がん学会学術集会(招待講演)
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 子宮頸癌に対するIn room CT-guided brachytherapy2011

    • Author(s)
      大野達也、野田真永、中野隆史
    • Organizer
      日本放射線腫瘍学会第24回学術大会 シンポジウム(招待講演)
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 子宮頸癌に対する画像誘導小線源治療

    • Author(s)
      大野達也
    • Organizer
      がんプロフェッショナル養成基盤推進プラン 東海大学公開シンポジウム
    • Place of Presentation
      伊勢原
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ワークショップ:子宮頸癌に対するBrachytherapy:2Dから3Dへ

    • Author(s)
      大野達也、野田真永、田巻倫明、尾池貴洋、安藤謙、清原浩樹、高草木陽介、渋谷圭、中野隆史
    • Organizer
      小線源治療部会第15回学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 実践マイクロセレクトロンHDRを用いた高線量率小線源治療ガイダンス20132013

    • Author(s)
      大野達也、野田真永
    • Publisher
      マイクロセレクトロンHDR研究会
    • Related Report
      2013 Final Research Report
  • [Book] 小線源治療ガイドラインに基づく密封小線源治療診療・物理QAマニュアル2013

    • Author(s)
      大野達也
    • Publisher
      金原出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] Ion Beam Therapy - Fundamentals, Technology, Clinical Application.2013

    • Author(s)
      Ohno T, Kato S.
    • Total Pages
      729
    • Publisher
      Springer-Verlag.
    • Related Report
      2013 Annual Research Report
  • [Book] Ion Beam Therapy - Fundamentals, Technology, Clinical Application2012

    • Author(s)
      Ohno T, Kato S
    • Publisher
      Springer-Verlag
    • Related Report
      2013 Final Research Report
  • [Book] Ion Beam Therapy for Gynecological Tumors.2012

    • Author(s)
      Ohno T, Kato S.
    • Total Pages
      729
    • Publisher
      Springer
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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