| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
STK38 (Serine/threonine kinase 38), also known as NDR1 (nuclear Dbf2-related 1), is a serine/threonine protein kinase belonging to a subclass of the protein kinase A (PKA)/PKG/PKC-like (AGC) family. I have recently reported that STK38 is activated by oxidative stresses such as X-irradiation or H2O2, and that knockdown of STK38 enhanced cellular sensitivity to DNA damage. To further clarify a role of STK38 in DNA damage response, I tried to identify a substrate of STK38 using phosoproteome analysis. I have identified not less than 30 in vitro substrates, some of which are known to be implicated in DNA damage response such as DNA repair, cell cycle checkpoint arrest, and apoptosis. I have investigated the significance of the STK38-mediated phosphorylation of their substrates
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