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Fundamental study for development of a new preventive method of radiation pneumonitis

Research Project

Project/Area Number 23591835
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

IGAKI Hiroshi  東京大学, 医学部附属病院, 講師 (90361344)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords放射線肺臓炎 / スピロノラクトン / レニン‐アンギオテンシン‐アルドステロン系 / レニン-アンギオテンシン-アルドステロン系
Research Abstract

The purpose of this study was to reveal the anti-fibrotic effect of spironolactone after pulmonary irradiation by an experimental system of rats. Female Wistar rats underwent local irradiation of the right whole thorax with a single dose of 15Gy by 200kVp x-rays. 90-day release pellets of 200mg of spironolactone were implanted in the rat's left back subcutaneously before or after irradiation. 13 weeks after irradiation, rats were sacrificed and bilateral lungs were removed and fixed in buffered formaldehyde for histopathological examinations. Fibrotic changes and foamy macrophage infiltrations were evaluated for each lung. The fibrotic changes of the irradiated lungs were severer when spironolactone was administered before irradiation. If spironolactone administration was delayed after irradiation, fibrotic change was not suppressed by spironolactone. Foamy macrophage infiltrations were not significantly different among the groups of different timings of spironolactone administration.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (56 results)

All 2014 2013 2012 2011

All Journal Article (32 results) (of which Peer Reviewed: 11 results) Presentation (21 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Corticospinal tract-sparing intensity-modulated radiotherapy treatment planning2014

    • Author(s)
      Igaki H, Sakumi A, Mukasa A, Saito K, Kunimatsu A, Masutani Y, Hanakita S, Ino K, Haga A, Nakagawa K, Ohtomo K
    • Journal Title

      Rep Pract Oncol Radiother

      Volume: (in press)

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Longitudinal Assessments of Quality of Life and Late Toxicities Before and After Definitive Chemoradiation for Esophageal Cancer2014

    • Author(s)
      Yamashita H, Omori M, Okuma K, Kobayashi R, Igaki H, Nakagawa K
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44(1) Pages: 78-84

    • Related Report
      2013 Final Research Report
  • [Journal Article] Impact of flattening-filter-free techniques on delivery time for lung stereotactic volumetric modulated arc therapy and image quality of concurrent kilovoltage cone-beam computed tomography : a preliminary phantom study2014

    • Author(s)
      Nakagawa K, Haga A, Sakumi A, Yamashita H, Igaki H, Shiraki T, Ohtomo K, Iwai Y, Yoda K
    • Journal Title

      J Radiat Res

      Volume: 55(1) Pages: 200-202

    • Related Report
      2013 Final Research Report
  • [Journal Article] Non-invasive objective evaluation of radiotherapy-induced dry mouth2014

    • Author(s)
      Fujimaki Y, Tsunoda K, Ishimoto SI, Okada K, Kinoshita M, Igaki H, Terahara A, Asakage T, Yamasoba T
    • Journal Title

      J Oral Pathol Med

      Volume: 43(2) Pages: 97-102

    • Related Report
      2013 Final Research Report
  • [Journal Article] The long-term outcomes of radiosurgery for intracranial hemangioblastomas2014

    • Author(s)
      Hanakita S, Koga T, Shin M, Takayanagi S, Mukasa A, Tago M, Igaki H, Saito N.
    • Journal Title

      Neuro Oncol

      Volume: 16 Issue: 3 Pages: 429

    • DOI

      10.1093/neuonc/not201

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of flattening-filter-free techniques on delivery time for lung stereotactic volumetric modulated arc therapy and image quality of concurrent kilovoltage cone-beam computed tomography : a preliminary phantom study2014

    • Author(s)
      Nakagawa K, Haga A, Sakumi A, Yamashita H, Igaki H, Shiraki T, Ohtomo K, Iwai Y, Yoda K
    • Journal Title

      J Radiat Res

      Volume: 55(1) Issue: 1 Pages: 200-2

    • DOI

      10.1093/jrr/rrt105

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal assessments of quality of life and late toxicities before and after definitive chemoradiation for esophageal cancer2014

    • Author(s)
      Yamashita H, Omori M, Okuma K, Kobayashi R, Igaki H, Nakagawa K
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44(1) Issue: 1 Pages: 78-84

    • DOI

      10.1093/jjco/hyt170

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive objective evaluation of radiotherapy-induced dry mouth.2014

    • Author(s)
      Fujimaki Y, Tsunoda K, Ishimoto SI, Okada K, Kinoshita M, Igaki H, Terahara A, Asakage T, Yamasoba T.
    • Journal Title

      J Oral Pathol Med.

      Volume: 43 Issue: 2 Pages: 97-102

    • DOI

      10.1111/jop.12099

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The long-term outcomes of radiosurgery for intracranial hemangioblastomas2013

    • Author(s)
      Hanakita S, Koga T, Shin M, Takayanagi S, Mukasa A, Tago M, Igaki H, Saito N
    • Journal Title

      Neuro Oncol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Japanese Society for Therapeutic Radiology and Oncology Health Insurance Committee. A Newly Introduced Comprehensive Consultation fee in the National Health Insurance System in Japan : A Promotive Effect of Multidisciplinary Medical Care in the Field of Radiation Oncology--Results from a Questionnaire Survey2013

    • Author(s)
      Igaki H, Onishi H, Nakagawa K, Dokiya T, Nemoto K, Shigematsu N, Nishimura Y, Hiraoka M
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43(12) Pages: 1233-1237

    • Related Report
      2013 Final Research Report
  • [Journal Article] Role of Gamma Knife surgery for intracranial atypical (WHO Grade II) meningiomas2013

    • Author(s)
      Hanakita S, Koga T, Igaki H, Murakami N, Oya S, Shin M, Saito N
    • Journal Title

      J Neurosurg

      Volume: 119(6) Pages: 1410-1414

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters2013

    • Author(s)
      Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
    • Journal Title

      Radiol Phys Technol

      Volume: 6(2) Pages: 335-342

    • Related Report
      2013 Final Research Report
  • [Journal Article] 外来放射線照射診療料運用の実態―日本放射線腫瘍学会アンケート調査結果の解析―2013

    • Author(s)
      井垣浩、大西洋、中川恵一、茂松直之、根本建二、西村恭昌、平岡眞寛
    • Journal Title

      臨床放射線

      Volume: 58(2) Pages: 364-371

    • NAID

      40019590179

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肝細胞癌治療アルゴリズムからみた放射線治療2013

    • Author(s)
      井垣浩、櫻井英幸
    • Journal Title

      肝胆膵

      Volume: 67(2) Pages: 211-220

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 悪性黒色腫に対する定位放射線治療の適応と臨床効果(特集皮膚悪性腫瘍―基礎と臨床の最新研究動向―)2013

    • Author(s)
      井垣浩、花北俊哉、中川恵一、大友邦
    • Journal Title

      日本臨牀

      Volume: 71(Suppl4) Pages: 365-369

    • Related Report
      2013 Final Research Report
  • [Journal Article] 放射線治療におけるチーム医療(特集チーム医療で支えるがん医療)2013

    • Author(s)
      井垣浩、白木尚、山上睦実、芳賀昭弘、中川恵一
    • Journal Title

      癌と化学療法

      Volume: 40(4) Pages: 440-443

    • Related Report
      2013 Final Research Report
  • [Journal Article] A newly introduced comprehensive consultation fee in the national health insurance system in Japan : a promotive effect of multidisciplinary medical care in the field of radiation oncology--results from a questionnaire survey2013

    • Author(s)
      Igaki H, Onishi H, Nakagawa K, Dokiya T, Nemoto K, Shigematsu N, Nishimura Y, Hiraoka M; Japanese Society for Therapeutic Radiology and Oncology Health Insurance Committee
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43(12) Issue: 12 Pages: 1233-7

    • DOI

      10.1093/jjco/hyt147

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of gamma knife surgery for intracranial atypical (WHO grade II) meningiomas: Clinical article2013

    • Author(s)
      Hanakita S, Koga T, Igaki H, Murakami N, Oya S, Shin M, Saito N.
    • Journal Title

      J Neurosurg

      Volume: 119 Issue: 6 Pages: 1410

    • DOI

      10.3171/2013.8.jns13343

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters2013

    • Author(s)
      Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
    • Journal Title

      Radiol Phys Technol

      Volume: 6 Issue: 2 Pages: 335

    • DOI

      10.1007/s12194-013-0205-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 外来放射線照射診療料運用の実態 ―日本放射線腫瘍学会アンケート調査結果の解析―2013

    • Author(s)
      井垣 浩、大西 洋、中川 恵一、茂松 直之、根本 建二、西村 恭昌、平岡 眞寛
    • Journal Title

      臨床放射線

      Volume: 58 Pages: 364-371

    • NAID

      40019590179

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Journal Article] 悪性黒色腫に対する定位放射線治療の適応と臨床効果2013

    • Author(s)
      井垣浩、花北俊哉、中川恵一、大友邦
    • Journal Title

      日本臨牀

      Volume: 71(Suppl4) Pages: 365-369

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 放射線治療におけるチーム医療2013

    • Author(s)
      井垣 浩、白木 尚、山上 睦実、芳賀 昭弘、中川 恵一
    • Journal Title

      癌と化学療法

      Volume: 40 Pages: 440-443

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Journal Article] 悪性黒色腫に対する定位放射線治療の適応と臨床効果2013

    • Author(s)
      井垣 浩、花北 俊哉、中川 恵一、大友 邦
    • Journal Title

      日本臨牀

      Volume: 未定

    • Related Report
      2012 Research-status Report
  • [Journal Article] Role of Gamma Knife surgery in the treatment of intracranial dural arteriovenous fistulas.2012

    • Author(s)
      Hanakita S, Koga T, Shin M, Shojima M, Igaki H, Saito N.
    • Journal Title

      J Neurosurg

      Volume: 117 Suppl Issue: Special_Suppl Pages: 158

    • DOI

      10.3171/2012.7.gks12967

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of Stereotactic Radiosurgery in the Treatment of High-Grade Cerebral Arteriovenous Malformation2012

    • Author(s)
      Hanakita S, Koga T, Shin M, Shojima M, Igaki H, Saito N
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 52 Issue: 12 Pages: 845-851

    • DOI

      10.2176/nmc.52.845

    • NAID

      10031131525

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Integration of Corticospinal Tractography Reduces Motor Complications After Radiosurgery.2012

    • Author(s)
      Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N.
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of adverse events associated with preoperative radiotherapy for rectal cancer2012

    • Author(s)
      Ishihara S, Watanabe T, Akahane T, Shimada R, Horiuchi A, Shibuya H, Hayama T, Yamada H, Nozawa K, Igaki H, Matsuda K.
    • Journal Title

      Int J Colorectal Dis.

      Volume: 26 Issue: 7 Pages: 911

    • DOI

      10.1007/s00384-011-1156-1

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 医療機関における放射線診療と安全性2012

    • Author(s)
      井垣浩、中川恵一
    • Journal Title

      日本臨牀

      Volume: 70 Pages: 475-478

    • Related Report
      2011 Research-status Report
  • [Journal Article] Integration of corticospinal tractography reduces motor complications after radiosurgery2011

    • Author(s)
      Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 83 Issue: 1 Pages: 129

    • DOI

      10.1016/j.ijrobp.2011.05.036

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 悪性神経膠腫2011

    • Author(s)
      井垣浩、作美明、中川恵一
    • Journal Title

      映像情報Medical

      Volume: 43 Pages: 935-939

    • Related Report
      2011 Research-status Report
  • [Journal Article] 放射線治療の現状と展望 ―高精度放射線治療を中心に―2011

    • Author(s)
      井垣浩、中川恵一
    • Journal Title

      成人病と生活習慣病

      Volume: 41 Pages: 515-519

    • Related Report
      2011 Research-status Report
  • [Journal Article] 肝癌の最新放射線治療  定位放射線治療 -IGRTも含めて2011

    • Author(s)
      井垣浩
    • Journal Title

      インナービジョン

      Volume: 26 Pages: 63-65

    • Related Report
      2011 Research-status Report
  • [Presentation] 膵癌放射線治療方法の検討2013

    • Author(s)
      井垣浩、白石憲史郎、中川恵一
    • Organizer
      第8回膵癌術前治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect Of Radiation-induced Pulmonary Fibrosis By Spironolactone2013

    • Author(s)
      Igaki H, Nomoto A, Shiraishi K, Enomoto A, Miyagawa K, Nakagawa K
    • Organizer
      ASTRO 55th annual meeting
    • Place of Presentation
      Georgia, Atlanta
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of skull shape approximation methods on Gamma Plan dose calculation2013

    • Author(s)
      Igaki H, Hanakita S, Sakumi A, Nomoto A, Shin M, Nakagawa K, Ohtomo K
    • Organizer
      11th International Stereotactic Radiosurgery Society Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Conventional and stereotactic radiotherapy for WHO grade II/III meningiomas2013

    • Author(s)
      Igaki H, Hanakita S, Onoe T, Nakagawa K
    • Organizer
      2nd ESTRO Forum
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2013 Final Research Report
  • [Presentation] スピロノラクトンによる放射線照射後の肺線維化阻害作用2013

    • Author(s)
      井垣浩、野元昭弘、白石憲史郎、榎本敦、宮川清、中川恵一
    • Organizer
      日本放射線腫瘍学会第26回学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝癌診療ガイドライン第3版試案公聴会放射線治療2013

    • Author(s)
      井垣浩
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭蓋形状計測方法の違いによるガンマナイフ治療時間の変化2013

    • Author(s)
      井垣浩、花北俊哉、作美明、野元昭弘、辛正廣、中川恵一、大友邦
    • Organizer
      第22回日本定位放射線治療学会
    • Place of Presentation
      桑名
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect Of Radiation-induced Pulmonary Fibrosis By Spironolactone2013

    • Author(s)
      Igaki H, Nomoto A, Shiraishi K, Enomoto A, Miyagawa K, Nakagawa K.
    • Organizer
      ASTRO 55th annual meeting
    • Place of Presentation
      Georgia, Atlanta, USA (Georgia World Congress Center)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effect of skull shape approximation methods on Gamma Plan dose calculation.2013

    • Author(s)
      Igaki H, Hanakita S, Sakumi A, Nomoto A, Shin M, Nakagawa K, Ohtomo K.
    • Organizer
      11th International Stereotactic Radiosurgery Society Congress
    • Place of Presentation
      Toronto, Canada (Sheraton Centre)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Conventional and stereotactic radiotherapy for WHO grade II/III meningiomas.2013

    • Author(s)
      Igaki H, Hanakita S, Onoe T, Nakagawa K
    • Organizer
      2nd ESTRO Forum
    • Place of Presentation
      Geneva, Switzerland (Palexpo)
    • Related Report
      2013 Annual Research Report
  • [Presentation] スピロノラクトンによる放射線照射後の肺線維化阻害作用2013

    • Author(s)
      井垣浩、野元昭弘、白石憲史郎、榎本敦、宮川清、中川恵一
    • Organizer
      日本放射線腫瘍学会第26回学術大会
    • Place of Presentation
      青森(ホテル青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝癌診療ガイドライン第3 版試案公聴会 放射線治療2013

    • Author(s)
      井垣浩
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 膵癌放射線治療方法の検討2013

    • Author(s)
      井垣浩、白石憲史郎、中川恵一
    • Organizer
      第8回膵癌術前治療研究会
    • Place of Presentation
      東京(ハイアットリージェンシー東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭蓋形状計測方法の違いによるガンマナイフ治療時間の変化2013

    • Author(s)
      井垣浩、花北俊哉、作美明、野元昭弘、辛正廣、中川恵一、大友邦
    • Organizer
      第22回日本定位放射線治療学会
    • Place of Presentation
      桑名(長島温泉ホテル花水木)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Atypical/anaplastic meningiomaに対する放射線治療2012

    • Author(s)
      井垣浩、尾上剛士、中川恵一、大友邦
    • Organizer
      第71回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 甲状腺癌髄膜転移に対してガンマナイフ治療を施行した2例2012

    • Author(s)
      井垣浩、花北俊哉、尾上剛士、甲賀智之、芝田紫野、中川恵一、大友邦
    • Organizer
      第21回日本定位放射線治療学会
    • Place of Presentation
      前橋
    • Related Report
      2012 Research-status Report
  • [Presentation] 異型性 / 退形成性髄膜腫に対する通常分割照射・定位照射2012

    • Author(s)
      井垣浩、花北俊哉、尾上剛士、中川恵一
    • Organizer
      日本放射線腫瘍学会第25回学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Diffusion tensor tractographyを用いて錐体路をOARとするIMRT計画の試み2011

    • Author(s)
      井垣浩、齊藤邦昭、甲賀智之、尾上剛士、武笠晃丈、國松聡、寺原敦朗、多湖正夫、中川恵一、大友邦
    • Organizer
      日本放射線腫瘍学会第24回学術大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 中枢神経腫瘍2011

    • Author(s)
      井垣浩、中川恵一
    • Organizer
      第49回日本癌治療学会学術集会シンポジウム(招待講演)
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Monacoを用いた頭頸部癌に対するVMAT治療計画2011

    • Author(s)
      井垣浩、寺原敦朗、中川恵一
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 肝細胞癌における放射線誘発肝障害と正常肝DVHの関係2011

    • Author(s)
      井垣浩、白石憲史郎、大熊加恵、加藤大基、山下英臣、中川恵一、大友邦
    • Organizer
      第70回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Book] 科学的根拠に基づく肝癌診療ガイドライン2013年版2013

    • Author(s)
      井垣浩他
    • Publisher
      日本肝臓学会編金原出版東京
    • Related Report
      2013 Final Research Report
  • [Book] 科学的根拠に基づく肝癌診療ガイドライン2013年版2013

    • Author(s)
      井垣浩(日本肝臓学会 編集)
    • Total Pages
      224
    • Publisher
      金原出版
    • Related Report
      2013 Annual Research Report
  • [Book] 1巻 放射線医学総論(シリーズ「放射線医学」)2012

    • Author(s)
      井垣浩、中川恵一(富山憲幸、中川恵一 編集)
    • Publisher
      金芳堂
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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