Abscopal effect based on tumor immunology and revolutionary strategy of radiation therapy

• Project/Area Number: 23591837
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: SHIRAISHI Kenshiro 東京大学, 医学部附属病院, 助教 (40447404)
• Co-Investigator(Kenkyū-buntansha): NIIBE Yuzuru 北里大学, 医学部, 講師 (00372912)
• Co-Investigator(Renkei-kenkyūsha): NAKAGAWA Keiichi 東京大学, 医学部附属病院, 准教授 (80188896)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 腫瘍免疫 / アブスコパル / 放射線治療

Research Abstract

Basic research using tumor-bearing mice via irradiation with immunostimulant agents was conducted. CD4+ cells, CD8+ cells and NK/NKT cells were identified as candicates of effector cells.
To consistent induction of abscopal effects, various combinations of irradiation of 6 Gy (6MeV-electron beam) with intravenous infusion of chemokine ECI301 after implantation of different tumor cells into bilateral flanks of BALB/c mice were conducted. We observed significant abscopal effects in several settings.

Research Products

• [Journal Article] Salvage radiation therapy and chemoradiation therapy for postoperative locoregional recurrence of esophageal cancer (2014)
  • Author(s): Kobayashi R, Yamashita H, Okuma K, Shiraishi K, Ohtomo K, Nakagawa K
  • Journal Title: Dis Esophagus
• [Journal Article] Independent absorbed-dose calculation using the Monte Carlo algorithm in volumetric modulated arc therapy (2014)
  • Author(s): Haga A, Magome T, Takenaka S, Imae T, Sakumi A, Nomoto A, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
  • Journal Title: Radiat Oncol
• [Journal Article] Salvage radiation therapy and chemoradiation therapy for postoperative locoregional recurrence of esophageal cancer. (2014)
  • Author(s): Kobayashi R, Yamashita H, Okuma K, Shiraishi K, Ohtomo K, Nakagawa K.
  • Journal Title: Dis Esophagus Volume: 27 Issue: 1 Pages: 72-8
  • DOI: 10.1111/dote.12068
  • Peer Reviewed
• [Journal Article] Independent absorbed-dose calculation using the Monte Carlo algorithm in volumetric modulated arc therapy. (2014)
  • Author(s): Haga A, Magome T, Takenaka S, Imae T, Sakumi A, Nomoto A, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K.
  • Journal Title: Radiattion Oncology Volume: 9 Issue: 1 Pages: 1-9
  • DOI: 10.1186/1748-717x-9-75
  • Peer Reviewed / Open Access
• [Journal Article] Correlation among 16 biological factors [p53, p21(waf1), MIB-1 (Ki-67), p16(INK4A), cyclin D1, E-cadherin, Bcl-2, TNF-α, NF-κB, TGF-β, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1α] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma (2013)
  • Author(s): Shibata-Kobayashi S, Yamashita H, Okuma K, Shiraishi K, Igaki H, Ohtomo K, Nakagawa K
  • Journal Title: Oncol Lett
• [Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters (2013)
  • Author(s): Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
  • Journal Title: Radiol Phys Technol
• [Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters (2013)
  • Author(s): Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
  • Journal Title: Radiol Phys Technol Volume: 6(2) Issue: 2 Pages: 335-42
  • DOI: 10.1007/s12194-013-0205-6
  • Peer Reviewed
• [Journal Article] Single-Arc Volumetric Modulated Arc Therapy Planning for Left Breast Cancer and Regional Nodes (2012)
  • Author(s): Sakumi A, Shiraishi K, Onoe T, Yamamoto K,Haga A, Yoda K, Nakagawa K, Ohtomo K
  • Journal Title: Journal of Radiation Research Pages: 151-3
  • NAID: 10030023919
• [Journal Article] Four-dimensional measurement of the displacement of internal fiducial and skin markers during 320- multislice computed tomography scanning of breast cancer (2012)
  • Author(s): Yamashita H, Okuma K, Tada K, Shiraishi K,Takahashi W, Shibata-Mobayashi S, Sakumi A,Saotome N, Haga A, Onoe T, Ino K, Akahane M,Ohtomo K, Nakagawa K
  • Journal Title: Int J Radiat Oncol Biol Phys Pages: 331-5
• [Journal Article] Stereotactic Body Radiotherapy for Metastatic Lung Cancer as Oligo-Recurrence : An Analysis of 42 Cases (2012)
  • Author(s): Takahashi W, Yamashita H, Niibe Y, Shiraishi K,Hayakawa K, Nakagawa K
  • Journal Title: Pulmonary Medicine
• [Journal Article] Stereotactic body radiotherapy for metastatic lung cancer as oligo-recurrence: an analysis of 42 cases (2012)
  • Author(s): Takahashi W
  • Journal Title: Pulm Med. Volume: なし Pages: 903-910
  • DOI: 10.1155/2012/454107
  • Peer Reviewed
• [Journal Article] Single-Arc Volumetric Modulated Arc Therapy Planning for Left Breast Cancer and Regional Nodes (2012)
  • Author(s): A.Sakumi, K.Shiraishi, T.Onoe, K.Yamamoto, A.HAGA, K.Yoda, K.Ohtomo, K.Nakagawa
  • Journal Title: Journal of Radiation Research Volume: 53 Issue: 1 Pages: 151-153
  • DOI: 10.1269/jrr.11159
  • NAID: 10030023919
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] Four-Dimensional Measurement of the Displacement of Internal Fiducial and Skin Markers During 320-Multislice Computed Tomography Scanning of Breast Cancer (2012)
  • Author(s): Hideomi Yamashita
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: Mar 19(Epub ahead of print) Issue: 2 Pages: 1-5
  • DOI: 10.1016/j.ijrobp.2011.12.030
  • Peer Reviewed
• [Journal Article] A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen (2011)
  • Author(s): Kakimi K, Isobe M, Uenaka A, Wada H, Sato E, Doki Y, Nakajima J, Seto Y, Yamatsuji T, Naomoto Y, Shiraishi K, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Oka M, Pan L, Hoffman EW, Old LJ, Nakayama E
  • Journal Title: International journal of cancer Journal international du cancer Volume: 129(12) Issue: 12 Pages: 2836-46
  • DOI: 10.1002/ijc.25955
  • Peer Reviewed
• [Journal Article] First In-situ Dose Calculation Report Using In-treatment Kilovoltage Cone-beam CT and In-treatment Linac Parameters during Volumetric Modulated Arc Therapy (2011)
  • Author(s): Sakumi A, Haga A, Kida S, Saotome N, Okano Y, Shiraishi K, Onoe T, Yoda K, Ohtomo K, Nakagawa K.
  • Journal Title: Journal of Radiation Research Volume: 52 Issue: 4 Pages: 536-537
  • DOI: 10.1269/jrr.11061
  • NAID: 10029122489
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] Omission of Axillary Lymph Node Dissection for Clinically Node Negative Early-Stage Breast Cancer Patients
  • Author(s): Kobayashi R, Shiraishi K, Iwase S, Ohtomo K, Nakagawa K
  • Journal Title: Breast Cancer Volume: (in press)
• [Presentation] Scattering contributions in out-of-field dosimetry using Monte Carlo calculation for breast conserving therapy. (2013)
  • Author(s): Shiraishi K, Sakumi A, Shiraki T, Haga A, Yoda K.
  • Organizer: The 2nd ESTRO (European Society for Therapeutic Radiology and Oncology Anniversary) Forum.
  • Place of Presentation: Geneva, Switzerland
• [Presentation] 乳房温存療法における照射範囲外の低線量評価と二次発癌. (2013)
  • Author(s): 白石憲史郎, 中川恵一, 河守次郎, 衣袋健司, 福内 敦, 西 常博, 白木 尚, 作美 明, 篠崎智大.
  • Organizer: 第21回日本乳癌学会学術総会
  • Place of Presentation: 静岡
• [Presentation] Impact of Intensive Local Control with Radiation Volumetric Modulated Arc Therapy (VMAT) in the Treatment of Localized Prostate Cancer: Initial Experience in 200 Patients. (2013)
  • Author(s): Shiraishi K, Yamamoto K, Haga A, Sakumi A, Futaguchi M, Nomoto A, Onoe T, Nakagawa K.
  • Organizer: The American Society for Therapeutic Radiology and Oncology 55th Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Secondary cancers after breast-conserving therapy in Tokyo database. (2013)
  • Author(s): Shiraishi K, Nakagawa K, Kawamori J, Ibukuro K, Fukuuchi A, Nishi T, Shinozaki T.
  • Organizer: The Breast Cancer Symposium
  • Place of Presentation: San Francisco, USA
• [Presentation] 乳房温存療法後の二次発癌は独立した予後不良因子である. (2013)
  • Author(s): 白石憲史郎, 中川恵一, 河守次郎, 衣袋健司, 福内 敦, 西 常博.
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] Biological subtype, but not age, adversely affects distant metastasis after breast-conserving therapy. (2012)
  • Author(s): Shiraishi K, Nakagawa K, Kawamori J, Ibukuro K, Fukuuchi A, Nishi T.
  • Organizer: The European Society for Radiotherapy and Oncology 31th Annual Meeting
  • Place of Presentation: Barcelona, Spain
• [Presentation] 限局性前立腺癌に対するIMRTの治療成績と有害事象 (2012)
  • Author(s): 白石憲史郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 低侵襲化が進む乳房温存療法における放射線治療の意義. (2012)
  • Author(s): 白石憲史郎, 中川恵一, 河守次郎, 衣袋健司, 福内 敦, 西 常博.
  • Organizer: 第20回日本乳癌学会学術総会
  • Place of Presentation: 熊本
• [Presentation] 前立腺癌に対する内分泌療法併用放射線治療の現状と近未来展望 (2012)
  • Author(s): 白石憲史郎.
  • Organizer: 第77回日本泌尿器科学会東部総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 乳房温存療法における照射範囲外の低線量評価と二次発癌. (2012)
  • Author(s): 白石憲史郎, 作美 明, 芳賀昭弘, 白木 尚, 中川恵一.
  • Organizer: 第50回日本癌治療学会総会
  • Place of Presentation: 横浜
• [Presentation] Abscopal effect in radiation therapy: Current concepts and future applications. (2012)
  • Author(s): Shiraishi K.
  • Organizer: The 31st Sapporo International Cancer Symposium
  • Place of Presentation: Sapporo, Hokkaido
  • Invited
• [Presentation] Impact of Intensive Local Control with Radiation Therapy for Bone-only Oligo-recurrenece on Long-term Results in Breast Cancer: A Multiinstitutional Study in Japan. (2011)
  • Author(s): Shiraishi K, Niibe Y, Nakagawa K, Takemoto M, Kaneyasu Y, Kanazawa S, Nagata Y, Hayakawa K.
  • Organizer: The American Society for Therapeutic Radiology and Oncology 53th Annual Meeting
  • Place of Presentation: Miami Beach, USA
• [Presentation] 乳房温存療法の長期成績と有害事象. (2011)
  • Author(s): 白石憲史郎, 小林伶子, 井垣 浩, 岩瀬 哲, 中川恵一.
  • Organizer: 第19回日本乳癌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] VMAT前立腺治療中の実際の投与線量―ConeBeamCTとログデータからの計算 (2011)
  • Author(s): 白石憲史郎, 作美 明, 芳賀昭弘, 尾上剛士, 早乙女直也, 依田 潔, 中川恵一
  • Organizer: 日本放射線腫瘍学会第24回学術大会
  • Place of Presentation: 神戸
• [Presentation] Biological subtype, but not age, adversely affects distant metastasis after breast-conserving therapy
  • Author(s): Shiraishi K, Nakagawa K, Kawamori J, Ibukuro K,Fukuuchi A, Nishi T
  • Organizer: The European Society for Radiotherapy and Oncology 31th Annual Meeting
• [Presentation] 限局性前立腺癌に対するIMRTの治療成績と有害事象
  • Author(s): 白石憲史郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Invited
• [Presentation] 低侵襲化が進む乳房温存療法における放射線治療の意義
  • Author(s): 白石憲史郎, 中川恵一, 河守次郎, 衣袋健司, 福内敦, 西常博
  • Organizer: 第20回日本乳癌学会学術総会
• [Presentation] 前立腺癌に対する内分泌療法併用放射線治療の現状と近未来展望白
  • Author(s): 石憲史郎
  • Organizer: 第77回日本泌尿器科学会東部総会
  • Invited
• [Presentation] 乳房温存療法における照射範囲外の低線量評価と二次発癌
  • Author(s): 白石憲史郎, 作美明, 芳賀昭弘, 白木尚, 中川恵一
  • Organizer: 第50回日本癌治療学会総会
• [Presentation] Abscopal effect in radiation therapy : Current concepts and future applications
  • Author(s): Shiraishi K
  • Organizer: The 31st Sapporo International Cancer Symposium
  • Invited
• [Book] Modern Practices in Radiation Therapy (2012)
  • Author(s): Shiraishi K., et al
• [Book] Modern Practices in Radiation Therapy (2012)
  • Author(s): Shiraishi K., et al.
  • Total Pages: 370
  • Publisher: InTech