Comprehensive analysis of molecular factors that impact on radiation dose response using the Linear-quadratic model
| Project/Area Number |
23591839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
SEO YUJI 大阪大学, 医学(系)研究科(研究院), 助教 (00302000)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | がん治療 / 放射線治療 / 定位放射線治療 / LQモデル / 放射線増感作用 / 線量依存性 / 効果予測 / ＬＱモデル |
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| Research Abstract |
In this study, I investigated an association between molecular factors and radiation dose response in 52 types of cancer cell lines using the Linear-quadratic model. The analysis revealed basal gene expression profiles and cancer gene mutation status that impact on the cellular response to a high-dose radiation per fraction compared with a lower-dose radiation. In addition, drug-radiation interactions were analyzed when radiation was given at a high dose versus low dose per fraction. The results suggested that there are several molecular targets and radiosensitizing agents that may affect treatment outcomes in a high-precision hypofractionated radiotherapy.
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Report
(4 results)
Research Products
(2 results)
