Design of radiosensitizers targeting for glycolysis of hypoxic tumor based on tumor implanted chick embryo
| Project/Area Number |
23591842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
UTO Yoshihiro 徳島大学, ソシオテクノサイエンス研究部, 准教授 (20304553)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 放射線腫瘍学 / 低酸素細胞放射線増感剤 / 腫瘍移植鶏卵 / 解糖系酵素 / 放射線増感剤 / 解糖系阻害 / グルコース / 2-ニトロイミダゾール / 発育鶏卵 / 低酸素腫瘍 |
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| Research Abstract |
The purpose of this research is the development of the "nitroazole-modified glucose type radiosensitizers" which gave the radiosensitizing active group to glucose used as the substrate of a glycolytic system paying attention to the hypoxic cancer cell being dependent on a glycolytic system. As contents of the research, the design and synthesis of acetylglucose-modified 2-nitroimidazole TX-2244 and its five derivatives were done, and analysis of radiosensitizing activity and its enhancing mechanism was conducted using tumor cells and a tumor-implanted chicken egg model. It was shown clearly that TX-2244 demonstrates high radiosensitizing activity as an obtained result through the prevention of intracellular uptake of glucose, the decrease of the level of intracellular NADH(s), and increase of DNA damage by radiation.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo2011
Author(s)
Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H
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Journal Title
J Radiat Res
Volume: 52
Pages: 208-14
NAID
Related Report
Peer Reviewed
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[Journal Article] Evaluation of the in vivo radiosensitizing activity of etanidazole using tumor-bearing chick embryo2011
Author(s)
Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H.
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Journal Title
Journal of Radiation Research
Volume: 52
Pages: 208-214
NAID
Related Report
Peer Reviewed
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[Presentation] 超音波による癌治療に対する5-aminolevulinic acidの増感作用の検討2014
Author(s)
島千尋,宇都義浩,玉谷大,水木佑輔,遠藤良夫,大久保敬,中西郁夫,石塚昌宏,田中徹,口池大輔,久保健太郎,乾利夫,堀均
Organizer
第16回癌治療増感研究シンポジウム
Place of Presentation
奈良県文化会館(奈良県)
Related Report
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[Presentation] Development of Immunomodulatory Cancer Therapy Based on Gc protein-derived Macrophage Activating Factor (GcMAF)2013
Author(s)
宇都義浩,竹内亮太,中川美典,廣田慶司,寺田弘,鬼塚伸也,久保健太郎,口池大輔,Mette Marty,乾利夫,遠藤良夫,堀均
Organizer
第7回ナノメディシン国際シンポジウム
Place of Presentation
九州工業大学(福岡県)
Related Report
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