| Project/Area Number |
23591843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Katsumasa 九州大学, 大学病院, 准教授 (20284507)
MIMORI Koushi 九州大学, 病院別府病院外科, 教授 (50322748)
田中 文明 九州大学, 大学病院, 助教 (30332836)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYANO Satoru 東京大学, 医科学研究所, 教授 (50128104)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 食道癌 / 放射線治療 / MicroRNA / 新規バイオマーカー / 放射線治療生物学 / Radiosensitivity / Esophageal cancer / 放射線感受性 / microRNA |
|---|
| Outline of Final Research Achievements |
On microaray for squamous cell carcinoma cell line established from esophageal cancer,miR hsa-miR-203a, hsa-miR-27a-3p and hsa-miR-205-5p were detected for candidate regulating radiosensitivity. On Gene Set Enrichment analysis based on Cancer cell line encyclopediaのgene expression array data, miR-203a was significantly higher expressed in radiosensitive esophageal cancer cellculture (TE9), compared to other esophageal cancer cell cultures. MiR-203a might be new bio-marker regulating radiosensitivity of esophageal cancer.
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