| Project/Area Number |
23591847
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANJI Susumu 岩手医科大学, 医学部泌尿器科学講座, 准教授 (40254776)
山口 哲 岩手医科大学, 医学部, 助教 (10611006)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Satoshi 岩手医科大学, PETリニアック先端医療センター, 助教 (10611006)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 前立腺癌 / 小線源治療 / 外照射放射線治療 / 放射線治療 / 直腸出血 / 生物学的等価線 / 併用放射線治療 |
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| Research Abstract |
We developed a novel method of plotting a rectal dose-volume histogram (DVH) for seed implant brachytherapy (BRT) combined with external beam radiotherapy (EBRT) by 3-dimensional summation of the comparably transformed dose maps distributed in an identical organ framework. Physical doses in DICOM-RT for each plan were converted to biologically effective doses (BED), and their corresponding voxel doses were integrated to a mono-scale dose map. Analysis of correlation between the summed rectal BED and post-treatment rectal bleeding revealed that rV150 (rectal volume exposed to 150 Gy in BED) > 1.2 cc promoted CTC-AE grade 2 or 3 rectal bleeding. The outcome ensures safety of the combined radiotherapy by quantifying the upper limit rectal dose in EBRT in accord with various antecedent BRT rectal exposure dose.
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