Prediction of PSA bounce after I-125 prostate brachytherapy

• Project/Area Number: 23591848
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokai University (2012-2013); Keio University (2011)
• Principal Investigator: SUGAWARA AKITOMO 東海大学, 医学部, 准教授 (80317239)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 前立腺癌 / 放射線治療

Research Abstract

The purpose of the present study was to determine factors that were associated with PSA bounce after I-125 prostate brachytherapy for patients with prostate cancer. After I-125 prostate brachytherapy, PSA was examined periodically. PSA bounce was defined as a rise of at least 0.1 ng/ml greater than a previous PSA level with a subsequent decline equal to, or less than, the initial nadir. As a result, PSA bounce occurred in 32% of patients. The incidence of PSA bounce was significantly higher in younger patients (<=67 years). In multivariate analysis, age was significantly associated with PSA bounce.