| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Research Abstract |
The differences in mutation induction and mutation spectrum between proton beams and X-rays in human cells were investigated. Cell killing effect was almost the same between proton beams and X-rays, while a difference in mutation frequency was observed and the frequency of hprt mutation of cells irradiated with proton beams was lower than that of cells irradiated with X-rays. Furthermore, the deletion spectrum of exons was different in induced mutants between proton beams and X-rays. These findings suggest that there are quantitative and qualitative differences in mutation induction between proton beams and X-rays even if the RBE values are similar.
|
