| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
As a new target of immunosuppression therapy for intestinal transplantation, we focused on intestinal macrophages. In this study, we used flow cytometry to analyze subsets of intestinal macrophages during acute rejection. Ectopic Itx was performed in rats; the transplant groups were syngeneic and allogeneic. We defined four subsets of rat intestinal macrophages using three monoclonal antibodies. These data suggest that the ED1+ macrophages contain four subsets, with the ED2+ED3+ subset strongly correlating with AR. This subset may be a novel target of immunosuppression therapy.
|
