New immunosuppressive therapy targeted to the intestinal macrophage for intestinal transplantation
Project/Area Number |
23591855
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Tohoku University |
Principal Investigator |
NIO Masaki 東北大学, 医学(系)研究科(研究院), 教授 (70228138)
|
Co-Investigator(Kenkyū-buntansha) |
WADA Motoshi 東北大学, 医学系研究科, 准教授 (80372291)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 小腸移植 / 自然免疫 / マクロファージ / 移植免疫 / 免疫学 |
Outline of Final Research Achievements |
As a new target of immunosuppression therapy for intestinal transplantation, we focused on intestinal macrophages. In this study, we used flow cytometry to analyze subsets of intestinal macrophages during acute rejection. Ectopic Itx was performed in rats; the transplant groups were syngeneic and allogeneic. We defined four subsets of rat intestinal macrophages using three monoclonal antibodies. These data suggest that the ED1+ macrophages contain four subsets, with the ED2+ED3+ subset strongly correlating with AR. This subset may be a novel target of immunosuppression therapy.
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Report
(5 results)
Research Products
(27 results)
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[Presentation] 客観的指標を用いた小腸移植後QOL変化の検討2014
Author(s)
工藤 博典,和田 基,佐々木 英之,風間 理郎, 田中 拡,中村 恵美,山木 聡史,鹿股 利一郎, 渡邊 智彦,仁尾 正記
Organizer
第25回日本小児外科QOL研究会
Place of Presentation
杏林大学医学部 大学院講堂(東京)
Year and Date
2014-10-18
Related Report
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[Presentation] 客観的指標による小腸移植後QOL変化の検討2014
Author(s)
工藤 博典,和田 基 ,佐々木 英之 ,田中 拡 ,仁尾 正記
Organizer
第41回 日本小児栄養消化器肝臓学会
Place of Presentation
東京ステーションコンファレンス(東京)
Year and Date
2014-10-02 – 2014-10-05
Related Report
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[Presentation] surgical problems of intestinal transplantation2014
Author(s)
Hironori Kudo, Motoshi Wada, Hideyuki Sasaki, Takuro Kazama, Kotaro Nishi, Hiromu Tanaka, Megumi Nakamura, Satoshi Yamaki, Riichiro Kanomata, Masaki Nio
Organizer
第51回 日本小児外科学会総会
Place of Presentation
大阪国際会議場(大阪)
Year and Date
2014-05-08 – 2014-05-10
Related Report
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