The antibody therapy for RAGE ligand in organ transplantation
| Project/Area Number | 23591864 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
SADAMORI HIROSHI 岡山大学, 医歯(薬)学総合研究科, 准教授 (30362974)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Hideo 近畿大学, 医学部, 教授 (60335627)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed(Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost : ¥4,200,000、Indirect Cost : ¥1,260,000)
Fiscal Year 2013 : ¥650,000 (Direct Cost : ¥500,000、Indirect Cost : ¥150,000)
Fiscal Year 2012 : ¥2,210,000 (Direct Cost : ¥1,700,000、Indirect Cost : ¥510,000)
Fiscal Year 2011 : ¥2,600,000 (Direct Cost : ¥2,000,000、Indirect Cost : ¥600,000)
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| Keywords | RAGEリガンド / 臓器移植 / 虚血再灌流障害 / 拒絶反応 / AGE / HMGB1 / 肝切除 / 外科侵襲 / HMGB-1 |
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| Research Abstract |
It has been reported that advanced glycation end products (AGEs) and high mobility group box-1 (HMGB-1), which function as a receptor for AGE (RAGE) ligand, contribute to the pathogenesis of chronic inflammatory diseases, such as atherosclerosis and diabetes. In the present research, we examined the effects of RAGE ligand on the mechanism of rejection and ischemia/reperfusion injury (I/R injury) in organ transplantation. As a result, the antibody therapy for RAGE ligand can contribute to management of the rejection and improvement of I/R injury in organ transplantation.
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Report
(4results)
Research Products
(106results)
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[Journal Article] Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability.2013
Author(s)
Umeda Y, Nagasaka T, Mori Y, Sadamori H, Sun DS, Shinoura S, Yoshida R, Satoh D, Nobuoka D, Utsumi M, Yoshida K, Yagi T, Fujiwara T
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Journal Title
J Hepatobiliary Pancreat Sci
Volume : 20
Pages : 223-233
DOI
Related Report
Peer Reviewed
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[Journal Article] Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy．2013
Author(s)
Nobuoka D, Yoshikawa T, Takahashi M, Iwama T, Horie K, Shimomura M, Suzuki S, Sakemura N, Nakatsugawa M, Sadamori H, Yagi T, Fujiwara T, Nakatsura T
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Journal Title
Cancer Immunol Immunother.
Volume : 62(4)
Pages : 639-52
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria．2013
Author(s)
Utsumi M, Umeda Y, Sadamori H, Nagasaka T, Takaki A, Matsuda H, Shinoura S, Yoshida R, Nobuoka D, Satoh D, Fuji T, Yagi T, Fujiwara T
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Journal Title
Transpl Int
Volume : 26(8)
Pages : 842-852
DOI
Related Report
Peer Reviewed
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[Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013
Author(s)
Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K
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Journal Title
J Gastroenterol
Volume : 48(12)
Pages : 1373-1383
DOI
Related Report
Peer Reviewed
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[Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013
Author(s)
Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K
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Journal Title
Journal of Gastroenterology
Volume : Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] Branched-chain amino acid-enriched nutrients improve nutritional and metabolic abnormalities in the early post-transplant period after living donor liver transplantation2012
Author(s)
Yoshida R, Yagi T, Sadamori H, Matsuda H, Shinoura S, Umeda Y, Sato D, Utsumi M, Nagasaka T, Okazaki N, Date A, Noguchi A, Tanaka A, Hasegawa Y, Sakamoto Y, Fujiwara T
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Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
Volume : 19(4)
Pages : 438-448
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats.2011
Author(s)
Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Maruo T, Date I, Yoshino T, Ohtsuka A, Mori S, Nishibori M.
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Journal Title
Stroke
Volume : 42(5)
Pages : 1420-1428
Related Report
Peer Reviewed
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