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The antibody therapy for RAGE ligand in organ transplantation

Research Project

Project/Area Number 23591864
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionOkayama University

Principal Investigator

SADAMORI HIROSHI  岡山大学, 医歯(薬)学総合研究科, 准教授 (30362974)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Hideo  近畿大学, 医学部, 教授 (60335627)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsRAGEリガンド / 臓器移植 / 虚血再灌流障害 / 拒絶反応 / AGE / HMGB1 / 肝切除 / 外科侵襲 / HMGB-1
Research Abstract

It has been reported that advanced glycation end products (AGEs) and high mobility group box-1 (HMGB-1), which function as a receptor for AGE (RAGE) ligand, contribute to the pathogenesis of chronic inflammatory diseases, such as atherosclerosis and diabetes. In the present research, we examined the effects of RAGE ligand on the mechanism of rejection and ischemia/reperfusion injury (I/R injury) in organ transplantation. As a result, the antibody therapy for RAGE ligand can contribute to management of the rejection and improvement of I/R injury in organ transplantation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (111 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (79 results) Book (5 results)

  • [Journal Article] Bloodless donor hepatectomy in living donor liver transplantation: counterclockwise liver rotation and early hanging maneuver.2013

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      J Gastrointest Surg.

      Volume: 17 Issue: 1 Pages: 203-206

    • DOI

      10.1007/s11605-012-1907-5

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] New surgical approach to large splenorenal shunt in living donor liver transplantation: diversion of SMV and SPV blood flow2013

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      J Gastrointest Surg

      Volume: 17 Issue: 2 Pages: 403-407

    • DOI

      10.1007/s11605-012-2006-3

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生体肝移植におけるhigh mobility group box-1の動態解析2013

    • Author(s)
      貞森裕、佐藤康晴、西堀正洋、佐藤太祐、信岡大輔、杉原正大、八木孝仁、藤原俊義
    • Journal Title

      日本消化器外科学会雑誌

      Volume: 46巻、3号 Pages: 232-235

    • NAID

      130004560934

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes2013

    • Author(s)
      Kohka Takahashi H、Sadamori H、Liu K、Wake H、Mori S、Yshino T、Yamamoto Y、Yamamoto H、Nishibori M
    • Journal Title

      Eur J Pharmacol

      Volume: Vol.20、No2 Pages: 223-233

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy.2013

    • Author(s)
      Nobuoka D, Yoshikawa T, Takahashi M, Iwama T, Horie K, Shimomura M, Suzuki S, Sakemura N, Nakatsugawa M, Sadamori H, Yagi T, Fujiwara T, Nakatsura T
    • Journal Title

      Cancer Immunol Immunother

      Volume: 62(4) Issue: 4 Pages: 639-652

    • DOI

      10.1007/s00262-012-1366-6

    • NAID

      120005315577

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria.2013

    • Author(s)
      Utsumi M, Umeda Y, Sadamori H, Nagasaka T, Takaki A, Matsuda H, Shinoura S, Yoshida R, Nobuoka D, Satoh D, Fuji T, Yagi T, Fujiwara T
    • Journal Title

      Transpl Int

      Volume: 26(8) Issue: 8 Pages: 842-852

    • DOI

      10.1111/tri.12138

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy2013

    • Author(s)
      Satoh D、Yagi T、Nagasaka T、Shinoura S、Umeda Y、Yoshida R、Utsumi M、Tanaka T、Sadamori H、Fujiwara T
    • Journal Title

      World J Hepatol

      Volume: Vol.5、No.4 Issue: 4 Pages: 189-195

    • DOI

      10.4254/wjh.v5.i4.189

    • NAID

      120005324792

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013

    • Author(s)
      Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K
    • Journal Title

      J Gastroenterol

      Volume: 48(12) Issue: 12 Pages: 1373-1383

    • DOI

      10.1007/s00535-013-0763-8

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histamine inhibits high mobility group box 1-induced adhesion molecule expression on human monocytes2013

    • Author(s)
      Takahashi H、Sadamori H、Teshigawara K、Niwa A、Liu K、Wake H、Mori S、Yoshino T、Nishibori M
    • Journal Title

      Eur J Phamacol

      Volume: Vol.718、No.1-3 Issue: 1-3 Pages: 305-313

    • DOI

      10.1016/j.ejphar.2013.08.017

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes2013

    • Author(s)
      Kohka Takahashi H, Sadamori H, Liu K, Wake H, Mori S, Yoshino T, Yamamoto Y, Yamamoto H, Nishibori M
    • Journal Title

      European Journal of Pharmacology

      Volume: 701(1-3) Issue: 1-3 Pages: 194-202

    • DOI

      10.1016/j.ejphar.2012.11.058

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013

    • Author(s)
      Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K
    • Journal Title

      Journal of Gastroenterology

      Volume: Epub ahead of print

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for organ/space surgical site infection after hepatectomy for hepatocellular carcinoma in 359 recent cases.2013

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 20 Issue: 2 Pages: 180-196

    • DOI

      10.1007/s00534-011-0503-5

    • NAID

      10031168209

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy: report of a case.2012

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      Hepatology Research

      Volume: 20 Issue: 12 Pages: 117-121

    • DOI

      10.1111/hepr.12080

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability.2012

    • Author(s)
      Yuzo Umeda
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 20 Issue: 2 Pages: 223-233

    • DOI

      10.1007/s00534-012-0531-9

    • NAID

      10031168213

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carcinosarcoma of the gallbladder manifesting as cholangitis due to hemobilia2012

    • Author(s)
      Sadamori H, Fujiwara H, Tanaka T, Yanai H, Satoh D, Yagi T,Fujiwara T
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: 16(6) Issue: 6 Pages: 1278-1281

    • DOI

      10.1007/s11605-012-1836-3

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Branched-chain amino acid-enriched nutrients improve nutritional and metabolic abnormalities in the early post-transplant period after living donor liver transplantation2012

    • Author(s)
      Yoshida R, Yagi T, Sadamori H, Matsuda H, Shinoura S, Umeda Y, Sato D, Utsumi M, Nagasaka T, Okazaki N, Date A, Noguchi A, Tanaka A, Hasegawa Y, Sakamoto Y, Fujiwara T
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 19(4) Issue: 4 Pages: 438-448

    • DOI

      10.1007/s00534-011-0459-5

    • NAID

      10030951037

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical rationalization of living donor liver transplantation by abolition of hepatic artery reconstruction under a fixed microscope2012

    • Author(s)
      Yagi T、Shinoura S、Umeda Y、Sato D、Yoshida R、Yoshida K、Utsumi M、Nobuoka D、Sadamori H、Fujiwara T
    • Journal Title

      Clin Transplant

      Volume: Vol.26、No.6 Pages: 877-883

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effect of omental flap in pancreaticoduodenectomy against postoperative pseudoaneurysm formation2012

    • Author(s)
      Matsuda H, Sadamori H, Umeda Y, Shinoura S, Yoshida R, Satoh D, Utsumi M, Yagi T, Fujiwara T
    • Journal Title

      Hepatogastroenterology

      Volume: 59(114) Issue: 114 Pages: 578-583

    • DOI

      10.5754/hge11452

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical rationalization of living donor liver transplantation by abolition of hepatic artery reconstruction under a fixed microscope.2012

    • Author(s)
      Yagi Takahito
    • Journal Title

      Clin Transplant

      Volume: 26 Issue: 6 Pages: 877-883

    • DOI

      10.1111/j.1399-0012.2012.01651.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intractable Bile Leakage after Hepatectomy for Hepatocellular Carcinoma in 359 Recent Cases.2012

    • Author(s)
      Sadamori H, Yagi T, Matsuda H, Shinoura S, Umeda Y, Fujiwara T.
    • Journal Title

      Digestive Surgery

      Volume: 29(2) Pages: 149-156

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum hepatitis B virus DNA before liver transplantation correlates with HBV reinfection rate even under successful low-dose hepatitis B immunoglobulin prophylaxis2011

    • Author(s)
      Yasunaka T、Takaki A、Yagi T、Iwasaki Y、Sadamori H、Koike K、Hirohata S、Tatsukawa M、Kawai D、Shiraha H、Miyake Y、Ikeda F、Kobashi H、Matsuda H、Shinoura S、Yoshida R、Satoh D、Utsumi M、Onishi T、Yamamoto K
    • Journal Title

      Hepatol Int

      Volume: Vol.5、No.4 Issue: 4 Pages: 918-926

    • DOI

      10.1007/s12072-011-9265-z

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukoencephalopathy syndrome after living-donor liver transplantation2011

    • Author(s)
      Umeda Y、Matsuda H、Sadamori H、Shinoura S、Yoshida R、Sato D、Utsumi M、Yagi T、Fujiwara T
    • Journal Title

      Exp Clin Transplant

      Volume: Vol.9、No.2 Pages: 139-144

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A prognostic model and treatment strategy for intrahepatic recurrence of hepatocellular carcinoma after curative resection2011

    • Author(s)
      Umeda Y、Matsuda H、Sadamori H、Matsukawa H、Yagi T、Fujiwara T
    • Journal Title

      World J Surg

      Volume: Vol.35、No.1 Issue: 1 Pages: 170-177

    • DOI

      10.1007/s00268-010-0794-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum hepatitis B virus DNA before liver transplantation correlates with HBV reinfection rate even under successful low-dose hepatitis B immunoglobulin prophylaxis.2011

    • Author(s)
      Yasunaka T, Takaki A, Yagi T, Iwasaki Y, Sadamori H, Yamamoto K, et al.
    • Journal Title

      Hepatology International

      Volume: 5(4) Pages: 918-926

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leukoencephalopathy syndrome after living-donor liver transplantation.2011

    • Author(s)
      Umeda Y, Matsuda H, Sadamori H, Shinoura S, Yoshida R, Sato D, Utsumi M, Yagi T, Fujiwara T.
    • Journal Title

      Experimental and Clinical Transplantation

      Volume: 9(2) Pages: 139-144

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A prognostic model and treatment strategy for intrahepatic recurrence of hepatocellular carcinoma after curative resection.2011

    • Author(s)
      Umeda Y, Matsuda H, Sadamori H, Matsukawa H, Yagi T, Fujiwara T.
    • Journal Title

      World Journal of Surgery

      Volume: 35(1) Pages: 170-177

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats.2011

    • Author(s)
      Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Maruo T, Date I, Yoshino T, Ohtsuka A, Mori S, Nishibori M.
    • Journal Title

      Stroke

      Volume: 42(5) Pages: 1420-1428

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Small for size syndromeに対する治療戦略-Portal modulationの意義と発症Riskを踏まえた治療個別化の可能性-2014

    • Author(s)
      楳田祐三
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉市
    • Year and Date
      2014-04-12
    • Related Report
      2013 Final Research Report
  • [Presentation] FREQUENCY OF REGULATORY T CELL AND HCV ANTIGEN SPECIFIC IMMUNE RESPONSE IN RECURRENT HEPATITIS C AFTER LIVER TRANSPLANTATION2013

    • Author(s)
      Utsumi M
    • Organizer
      21st United European Gastroenterology Week
    • Place of Presentation
      Berlin
    • Year and Date
      2013-10-16
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 臓器移植におけるHMGB-1を介した自然免疫機構の解析と制御2013

    • Author(s)
      貞森裕
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2013-09-07
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Frequency of regulatory T cell and HCV antigen-specific immune response in recurrent hepatitis C after liver transplantation2013

    • Author(s)
      内海方嗣
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2013-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝臓の虚血再灌流障害+肝切除モデルにおけるHMGB-1の動態・機能解析と制御2013

    • Author(s)
      杉原正大
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2013-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体肝移植後の肝腎不全に対する肝腎同時移植移植の適応2013

    • Author(s)
      八木孝仁
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2013-09-06
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] アルコール性肝硬変患者に対する肝移植適応基準確立に向けた岡山大学病院での取組み2013

    • Author(s)
      吉田龍一
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2013-09-06
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] The risk factors for fungal infection after living donor liver transplantation2013

    • Author(s)
      Utsumi M
    • Organizer
      The 13th Congress of the Asian Society of Transplantation
    • Place of Presentation
      京都市
    • Year and Date
      2013-09-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] The outcome of prophylatic surgical managements for spontaneous large splenorenal shunts adult living donor liver transplantation2013

    • Author(s)
      Sadamori H
    • Organizer
      The 13th Congress of the Asian Society of Transplantation
    • Place of Presentation
      京都市
    • Year and Date
      2013-09-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肝移植手術の血行再建における人工血管の使用経験2013

    • Author(s)
      信岡大輔
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Year and Date
      2013-07-19
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 温阻血再灌流+70%肝切除におけるHMGB1の動態解析と制御2013

    • Author(s)
      杉原正大
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Year and Date
      2013-07-19
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肝移植におけるERASプロトコル確立を目指して〜周術期栄養療法による早期回復効果を可視化する試み〜2013

    • Author(s)
      吉田龍一
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Year and Date
      2013-07-18
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 生体肝移植におけるドナー年齢限界の見極めと個別化治療戦略2013

    • Author(s)
      楳田祐三
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2013-07-05
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] NASH肝硬変における肝移植後の経過2013

    • Author(s)
      高木章乃夫
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2013-07-05
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 再肝移植症例に対する肝腎同時移植経験と、本邦の複数臓器分配におけるMELD scoreのもつ問題点2013

    • Author(s)
      八木孝仁
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2013-07-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肝移植後の真菌感染症の危険因子の解析2013

    • Author(s)
      内海方嗣
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2013-07-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 生体肝移植後拒絶反応およびC型肝炎再発におけるHigh Mobility Group Box-1の動態解析2013

    • Author(s)
      貞森裕
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2013-07-04
    • Related Report
      2013 Final Research Report
  • [Presentation] HMGB1制御による阻血再灌流障害の軽減効果と肝再生機序への影響解析2013

    • Author(s)
      杉原正大
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2013-07-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 低体重児に対するS2移植+ in situ reductionをもちいたsub-monosegment liver transplantation2013

    • Author(s)
      八木孝仁
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2013-06-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝腫瘍および生体肝移植ドナーにおける肝切離法の工夫2013

    • Author(s)
      貞森裕
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2013-06-13
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 脳死肝移植成績~当院15症例の検討~2013

    • Author(s)
      篠浦先
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2013-06-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 再発肝細胞癌の治療戦略~予後予測モデルとSalvage Transplantationの適応選別~2013

    • Author(s)
      楳田祐三
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2013-06-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 下大静脈合併切除再建を併施した切除不能肝芽腫に対する生体肝移植2013

    • Author(s)
      吉田龍一
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-04-13
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 生体肝移植ドナーにおける無血肝切除技術と胆道合併症の予防対策2013

    • Author(s)
      貞森裕
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-04-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 生体肝移植の短期・晩期予後向上に向けた治療戦略個別化の可能性2013

    • Author(s)
      楳田祐三
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-04-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肝細胞癌に対する生体肝移植適応基準についての検討2013

    • Author(s)
      佐藤太祐
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-04-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 生体肝移植における人工血管を用いた血行再建2013

    • Author(s)
      信岡大輔
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-04-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 温阻血再灌流+肝切除モデルにおけるHMGB1の動態解析および肝再生機序の解明2013

    • Author(s)
      杉原正大
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 低体重児に対するS2移植 + in situ reductionをもちいたsub-monosegment liver transplantation2013

    • Author(s)
      八木孝仁,貞森 裕,篠浦 先,楳田祐三,吉田龍一,佐藤太祐,内海方嗣,信岡大輔,杉原正大,藤 智和,高木弘誠,藤原俊義
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      宇都宮市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 乳児急性リンパ性白血病臍帯血移植後に発症した肝中心静脈閉塞症に対し生体肝移植,骨髄移植を施行した1例2013

    • Author(s)
      吉田龍一,高木弘誠,藤 智和,内海方嗣,信岡大輔,楳田祐三,篠浦 先,貞森 裕,保田裕子,藤原俊義,八木孝仁
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] "Frequency of regulatory T cell and HCV antigen-specific immune2013

    • Author(s)
      内海方嗣,高木 章,高木弘誠,信岡大輔,吉田龍一,楳田祐三,篠浦 先,貞森 裕,保田裕子,藤原俊義,八木孝仁
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Influence of Ischemia/Reperfusion Injury on HMGB1 State and Liver2013

    • Author(s)
      Masahiro Sugihara, Hiroshi Sadamori, Masahiro Nishibori, Yasuharu Sato,
    • Organizer
      Merinoff World Congress 2013:HMGB1
    • Place of Presentation
      New York
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体肝移植ドナーにおけるCounterclockwise Liver RotationとEarly Hanging Maneuverを併用した肝切除技術2012

    • Author(s)
      貞森裕
    • Organizer
      第74回日本臨床外科学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2012-12-01
    • Related Report
      2013 Final Research Report
  • [Presentation] アルコール性肝硬変患者に対する肝移植適応基準確立に向けた岡山大学病院での取組み2012

    • Author(s)
      吉田龍一
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 改正臓器移植法後の脳死肝移植の現状と問題点2012

    • Author(s)
      楳田祐三
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 更なる安全性確保を求めた生体肝移植ドナー手術手技2012

    • Author(s)
      貞森裕
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人生体肝移植の短期予後解析~Small-for-size syndrome発症リスクを踏まえた治療戦略の提言~2012

    • Author(s)
      藤智和
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 臓器移植におけるHigh morbidity group box-1の動態および機能解析2012

    • Author(s)
      貞森裕
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体肝移植ドナー手術における無血肝切除技術と胆道合併症予防対策の確立2012

    • Author(s)
      貞森裕
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山市
    • Year and Date
      2012-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体肝移植周術期栄養療法の有用性に関する検討~生体肝移植における至適ERASの確立を目指して~2012

    • Author(s)
      吉田龍一
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山市
    • Year and Date
      2012-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 急性肝不全に対する生体肝移植の展望2012

    • Author(s)
      吉田一博
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山市
    • Year and Date
      2012-07-18
    • Related Report
      2013 Final Research Report
  • [Presentation] PBCに対する生体部分肝移植術後の再発、長期予後についての検討2012

    • Author(s)
      内海方嗣
    • Organizer
      第24回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2012-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 高度の脾腎シャントを有する生体肝移植におけるシャント処理法と成績2012

    • Author(s)
      貞森裕
    • Organizer
      第24回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2012-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体部分肝移植後動脈および胆管合併症の危険因子の解析-移植前脾腫および脾動脈径の関与-2012

    • Author(s)
      佐藤太祐
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] HCCに対する安全・確実な門脈腫瘍栓摘出・再建術2011

    • Author(s)
      貞森裕
    • Organizer
      第73回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-19
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 高難度肝切除における無血肝切除技術の確立2011

    • Author(s)
      貞森裕
    • Organizer
      第73回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-17
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] IMMUNOHISTOCHEMICAL STAINING OF LIVER GRAFTS WITH A MONOCLONAL ANTIBODY AGAINST HCV-ENVELOPE 2 FOR RECURRENT HEPATITIS C AFTER LIVING DONOR LIVER TRANSPLANTATION2011

    • Author(s)
      Hiroshi Sadamori
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-11
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] TWO COMPARATIVE CASES OF FULMINANT HEPATIC FAILURE CAUSED BY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS OF EB VIRUS INFECTION-A PIT FALL OF PEDIATRIC LIVER TRANSPLANTATION2011

    • Author(s)
      Hiroshi Sadamori
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 生体肝移植術後の腎障害に対するRifle分類の有用性2011

    • Author(s)
      内海方嗣
    • Organizer
      第47回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-05
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 改正臓器移植法施行後の脳死肝移植における問題点2011

    • Author(s)
      楳田祐三
    • Organizer
      第29回日本肝移植研究会
    • Place of Presentation
      仙台
    • Year and Date
      2011-07-22
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 移植後肝疾患における末梢制御性T細胞の頻度の検討2011

    • Author(s)
      内海方嗣
    • Organizer
      第29回日本肝移植研究会
    • Place of Presentation
      仙台
    • Year and Date
      2011-07-22
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 生体肝移植周術期栄養療法に関する探索的臨床研究2011

    • Author(s)
      吉田龍一
    • Organizer
      第23回日本肝胆膵外科学会・学術集
    • Place of Presentation
      東京
    • Year and Date
      2011-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] AGE-2 and AGE-3 induce monocyte activation2011

    • Author(s)
      Hideo Kohka
    • Organizer
      第76回日本インターフェロン・サイトカイン学会・第19回国際マクロファージ分子細胞生物学シンポジウム合同開催国際会議
    • Place of Presentation
      泉佐野市
    • Year and Date
      2011-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] INTRACTABLE BILE LEAKAGE AFTER HEPATECTOMY FOR HEPATOCELLULAR CARCINOMA IN RECENT 359 CASES2011

    • Author(s)
      Hiroshi Sadamori,Takahito Yagi, Hiroaki Matsuda, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Daisuke Satoh, Daisuke Nobuoka, Masashi Utsumi, Kazuhiro Yoshida, Toshiyoshi Fujiwara
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Research-status Report
  • [Presentation] AGE-2 and AGE-3 induce monocyte activation.2011

    • Author(s)
      Hideo Kohka Takahashi, Shuji Mori, Atsuko Niwa, Masaki Tabuchi, Kyoko Nakamura, Kana Ohshima, Masahiro Nishibori
    • Organizer
      第76回日本インターフェロン・サイトカイン学会・第19回国際マクロファージ分子細胞生物学シンポジウム 合同開催 国際会議
    • Place of Presentation
      大阪府泉佐野市
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体肝移植周術期栄養療法に関する探索的臨床研究2011

    • Author(s)
      吉田龍一,八木孝仁,貞森 裕,松田浩明,篠浦 先,楳田祐三,佐藤太祐,内海方嗣,藤原俊義
    • Organizer
      第23回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 高度技能医修練における肝切除術前シミュレーションの有用性 -高度技能医修練者の肝前区域切除術-2011

    • Author(s)
      楳田祐三,松田浩明,貞森 裕,篠浦 先,吉田龍一,佐藤太祐,内海方嗣,八木孝仁,藤原俊義
    • Organizer
      第23回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 岡山大学病院における肝移植患者に対する全科横断的な取り組み2011

    • Author(s)
      吉田龍一,八木孝仁,貞森 裕,松田浩明,篠浦 先,楳田祐三,佐藤太祐,内海方嗣,高木章乃夫,山本和秀,松本洋輔,河本泰信,保田裕子,清水千聖,藤原俊義
    • Organizer
      第29回日本肝移植研究会
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] 大腸癌肝転移における治療戦略ー遺伝子変異情報を基盤とした治療戦略構築の可能性ー2011

    • Author(s)
      楳田祐三,永坂岳司,貞森 裕,松田浩明,篠浦 先,吉田龍一,佐藤太祐,内海方嗣,八木孝仁,藤原俊義
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 高度脈管侵襲肝癌に対する治療戦略-Vp3/4, Vv2/3進行肝癌の治療成績2011

    • Author(s)
      杭瀬 崇,楳田祐三,貞森 裕,松田浩明,篠浦 先,吉田龍一,佐藤太祐,内海方嗣,八木孝仁,藤原俊義
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳死肝移植登録医学的緊急性9点症例の経過と問題点2011

    • Author(s)
      高木章乃夫,八木孝仁,三宅康広,安中哲也,貞森 裕,松田浩明,篠浦 先,楳田祐三,吉田龍一,内海方嗣,藤原俊義,山本和秀
    • Organizer
      第95回日本消化器病学会中国支部例会
    • Place of Presentation
      米子
    • Related Report
      2011 Research-status Report
  • [Presentation] 劇症肝炎に対する肝移植の展望2011

    • Author(s)
      吉田一博,楳田祐三,貞森 裕,松田浩明,篠浦 先,吉田龍一,佐藤太祐,信岡大輔,吉田一博,保田裕子,八木孝仁,藤原俊義
    • Organizer
      第47回日本移植学会総会
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] BRAF変異大腸癌 -根治切除後の分子生物学的/臨床的特徴2011

    • Author(s)
      永坂 岳司,近藤 喜太、母里 淑子、森川 達也、楳田 祐三、田辺 俊介,野間 和広、岸本 浩行、 宇野 太、西崎 正彦、香川 俊輔、白川 靖博、貞森 裕、八木 孝仁、藤原 俊義
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 大腸癌肝転移 -遺伝子変異情報は肝切除のPredictive markerとなり得るか-2011

    • Author(s)
      楳田祐三,永坂 岳司、貞森 裕、松田 浩明、篠浦 先、吉田 龍一、佐藤 太祐、信岡 大輔、内海 方嗣、 吉田 一博、八木 孝仁、藤原 俊義
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 乳児急性リンパ性白血病臍帯血移植後に発症した肝中心静脈閉塞症に対し生体肝移植、骨髄移植を施行した1例2010

    • Author(s)
      吉田龍一
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-07-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体肝移植における人工血管の安全性と有用性の検討

    • Author(s)
      信岡大輔,楳田祐三,貞森 裕,篠浦 先,内海方嗣,佐藤太祐,吉田龍一,藤原俊義,八木孝仁
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] アルコール性肝硬変患者に対する肝移植適応基準確立に向けた岡山大学病院での取組み

    • Author(s)
      吉田龍一,内海方嗣,信岡大輔,佐藤太祐,楳田祐三,篠浦 先,貞森 裕,八木孝仁,保田裕子,藤原俊義
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 改正臓器移植法後の脳死肝移植登録の現状と問題点

    • Author(s)
      楳田祐三,八木孝仁,貞森 裕,高木章乃夫,篠浦 先,吉田龍一,信岡大輔,佐藤太祐,内海方嗣,保田裕子,藤原俊義
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 成人生体肝移植の短期予後解析~Small-for-size syndrome発症リスクを踏まえた治療戦略の提言~

    • Author(s)
      藤 智和,楳田祐三,貞森 裕,篠浦 先,吉田龍一,佐藤太祐,信岡大輔,内海方嗣,保田裕子,藤原俊義,八木孝仁
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 臓器移植におけるHigh morbidity group box-1の動態および機能解析

    • Author(s)
      貞森 裕,高橋英夫,佐藤康晴,佐藤太祐,信岡大輔,西堀正洋,八木孝仁,藤原俊義
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 更なる安全性確保を求めた生体肝移植ドナー手術手技

    • Author(s)
      貞森 裕,八木孝仁,篠浦 先,楳田祐三,吉田龍一,佐藤太祐,信岡大輔,保田裕子,藤原俊義
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 高度の脾腎シャントを有する生体肝移植におけるシャント処理法と成績

    • Author(s)
      貞森 裕,八木孝仁,篠浦 先,楳田祐三,吉田龍一,佐藤太祐,信岡大輔,内海方嗣,杉原正大,吉田一博,浦野真一,藤原俊義
    • Organizer
      第24回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Research-status Report
  • [Presentation] PBCに対する生体部分肝移植術後の再発、長期予後についての検討

    • Author(s)
      内海方嗣,吉田一博,信岡大輔,佐藤太祐,吉田龍一,楳田祐三,篠浦 先,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第24回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Research-status Report
  • [Presentation] 急性肝不全に対する生体肝移植の展望

    • Author(s)
      吉田一博,楳田祐三,貞森 裕,篠浦 先,吉田龍一,佐藤太祐,信岡大輔,内海方嗣,八木孝仁,藤原俊義
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山市
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体肝移植ドナー手術における無血肝切除技術と胆道合併症予防対策の確立

    • Author(s)
      貞森 裕,八木孝仁,篠浦 先,楳田祐三,吉田龍一,佐藤太祐,信岡大輔,内海方嗣,吉田一博,藤原俊義
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山市
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体肝移植周術期栄養療法の有用性に関する検討~生体肝移植における至適ERASの確立を目指して~

    • Author(s)
      吉田龍一,吉田一博,内海方嗣,信岡大輔,佐藤太佑,楳田祐三,篠浦 先,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山市
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体肝移植ドナーにおけるCounterclockwise Liver RotationとEarly Hanging Maneuverを併用した肝切除技術

    • Author(s)
      貞森 裕,八木孝仁,篠浦 先,楳田祐三,吉田龍一,佐藤太祐,信岡大輔,内海方嗣,藤原俊義
    • Organizer
      第74回日本臨床外科学会総会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体部分肝移植後 動脈および胆管合併症の危険因子の解析-移植前脾腫および脾動脈径の関与-

    • Author(s)
      佐藤太祐,八木孝仁,貞森 裕,松田浩明,篠浦 先,楳田祐三,吉田龍一,内海方嗣,吉田一博,信岡大輔
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2012 Research-status Report
  • [Presentation] Small for size syndrome に対する治療戦略-Portal modulation の意義と発症 Risk を踏まえた治療個別化の可能性

    • Author(s)
      楳田祐三,八木孝仁,貞森 裕,篠浦 先,吉田龍一,佐藤太祐,信岡大輔,内海方嗣,吉田一博,藤原俊義
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2012 Research-status Report
  • [Book] The Modulation of Portal Venous Hemodynamics in Living Donor Liver Transplantation. Hemodynamics: Monitoring, Theory and Applications2013

    • Author(s)
      Sadamori H, Umeda Y, Yagi T, Fujiwara T
    • Publisher
      Nova science publishers
    • Related Report
      2012 Research-status Report
  • [Book] LIVER BIOPSY IN MODERN MEDICINE2011

    • Author(s)
      Sadamori H et al.
    • Total Pages
      10
    • Publisher
      In Tech Pubisher
    • Related Report
      2013 Final Research Report
  • [Book] Liver Transplantation-Technical Issues and Complications2011

    • Author(s)
      Umeda Y et al.
    • Total Pages
      12
    • Publisher
      In Tech Pubisher
    • Related Report
      2013 Final Research Report
  • [Book] LIVER BIOPSY IN MODERN MEDICINE2011

    • Author(s)
      Sadamori H, Ogino T, Yagi T, Fujiwara T.
    • Total Pages
      10
    • Publisher
      InTech Publisher
    • Related Report
      2011 Research-status Report
  • [Book] Liver Transplantation-Technical Issues and Complications2011

    • Author(s)
      Umeda Y, Yagi T, Sadamori H, Fujiwara T.
    • Total Pages
      12
    • Publisher
      InTech Publisher
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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