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A study for improvement of pancreatic islet transplantation outcome by using two-layer method and rare sugar

Research Project

Project/Area Number 23591866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKagawa University

Principal Investigator

SUZUKI Yasuyuki  香川大学, 医学部, 教授 (40304092)

Co-Investigator(Kenkyū-buntansha) KASHIWAGI Hirotaka  香川大学, 医学部付属病院, 病院助 (20464365)
ASANO Eisuke  香川大学, 医学部付属病院, 病院助
TOKUDA Masaaki  香川大学, 医学部細胞情報生理学, 教授 (10163974)
OKANO Keiichi  香川大学, 医学部付属病院, 準教授 (20314916)
HOSSAIN M・a  香川大学, 医学部, 研究員
M・A HOSSAIN  香川大学, 医学部, その他 (20294754)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords希少糖 / 膵島移植 / 二層法 / D-アロース
Research Abstract

Islet transplantation is a curative treatment option for Type-1 diabetes. Improving islet function after isolation would result in better clinical outcomes of islet transplantation. In this study, we examined whether addition of D-allose, one of rare sugars, to islet culture medium had a beneficial effect on rat islet viability and function. As results, insulin secretion increased in the group with D-allose in overnight culture compared to the control without D-allose. In addition, diabetic nude mice transplanted islets after co-culture with D-allose demonstrated significantly higher cure rate of diabetes compared to the control. Because a oxidative stress marker (malondialdehyde) of islets was significantly reduced by co-culture with D-allose, this rare sugar possibly has an antioxidative effect.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Presentation (3 results)

  • [Presentation] 膵島移植における希少糖D-アロースの有用性の検討2014

    • Author(s)
      柏木裕貴
    • Organizer
      第41回膵・膵島移植研究会
    • Place of Presentation
      愛知県
    • Year and Date
      2014-03-07
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 膵島移植における希少糖D-アロースの可能性2013

    • Author(s)
      柏木裕貴
    • Organizer
      第40回膵・膵島移植研究会
    • Place of Presentation
      香川県
    • Year and Date
      2013-03-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵島移植における希少糖D-アロースの可能性2013

    • Author(s)
      柏木裕貴
    • Organizer
      第40回日本膵・膵島移植研究会
    • Place of Presentation
      香川県高松市
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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