A study for improvement of pancreatic islet transplantation outcome by using two-layer method and rare sugar
| Project/Area Number |
23591866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAGI Hirotaka 香川大学, 医学部付属病院, 病院助 (20464365)
ASANO Eisuke 香川大学, 医学部付属病院, 病院助
TOKUDA Masaaki 香川大学, 医学部細胞情報生理学, 教授 (10163974)
OKANO Keiichi 香川大学, 医学部付属病院, 準教授 (20314916)
HOSSAIN M・a 香川大学, 医学部, 研究員
M・A HOSSAIN 香川大学, 医学部, その他 (20294754)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 希少糖 / 膵島移植 / 二層法 / D-アロース |
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| Research Abstract |
Islet transplantation is a curative treatment option for Type-1 diabetes. Improving islet function after isolation would result in better clinical outcomes of islet transplantation. In this study, we examined whether addition of D-allose, one of rare sugars, to islet culture medium had a beneficial effect on rat islet viability and function. As results, insulin secretion increased in the group with D-allose in overnight culture compared to the control without D-allose. In addition, diabetic nude mice transplanted islets after co-culture with D-allose demonstrated significantly higher cure rate of diabetes compared to the control. Because a oxidative stress marker (malondialdehyde) of islets was significantly reduced by co-culture with D-allose, this rare sugar possibly has an antioxidative effect.
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Report
(4 results)
Research Products
(3 results)
