Regulation of systemic inflammatory response syndrome by TNF-related apoptosis inducing ligand which affect neutrophils exclusion and its potential clinical application.
Project/Area Number |
23591870
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Kumamoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Yoshihiro 熊本大学, 生命科学研究部, 教授 (30195341)
SAGISHIMA Katsuyuki 熊本大学, 医学部附属病院, 助教 (40336235)
HIROSAKO Susumu 熊本大学, 生命科学研究部, 助教 (70432995)
SAKAI Keisuke 熊本大学, 医学部附属病院, 助教 (10433038)
ARAKAWA Hirofumi 独立行政法人国立がん研究センター, 部長 (70313088)
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Co-Investigator(Renkei-kenkyūsha) |
SHIMOZATO Osamu 千葉県がんセンター, がん治療耐性克服研, 研究員 (30344063)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | SIRS / TRAIL / TRAIL受容体 / 好中球 / TNFα / IFNγ / アポトーシス / 実験医学 / 白血球 / 細胞死 / Leukocytes / 分子生物学 / TRAIL receptor |
Research Abstract |
We have been identified that neutrophils express TRAIL and TRAIL-R which were induced by IFNgamma and reduced by TNFalpha. Finally, TNFalpha induced the netrophils apoptosis and IFNgamma reduced. In the present study, leukocytes were isolated in peripheral blood and local exudates from post-operative drain in SIRS. The level of TRAIL, TRAIL-R1, and -R2 (death receptor) mRNA were significant higher and the level of TRAIL-R3 and -R4 (decoy receptor) mRNA were significant lower in leukocytes from exudates than leukocytes form peripheral blood. Up- or down-regulation of TRAIL receptor expression by TNFalpha or IFNgamma can affect the susceptibility of neutrophils to TRAIL. In local inflammatory field, neutophils are activated by high amount of cytokines and neutophils expressing TRAIL, -R1 and -R2 can transit to be apoptosis. TRAIL signaling pathway could potentially regulate the fate of tissue-infiltrating neutrophils during SIRS.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma2012
Author(s)
Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, Kinoshita K, Saito S, Baba Y, Baba H
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Journal Title
Annal of Surgical Oncology
Volume: 19 (Suppl 3)
Related Report
Peer Reviewed
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[Journal Article] Micro RNA- 200b regulates cellproliferation, invasion and migrationby directly targeting ZEB2 in gastriccarcinoma2012
Author(s)
Kurashige J, Kamohara H, Watanabe M,Hiyoshi Y, Iwatsuki M, Tanaka Y,Kinoshita K, Saito S, Baba Y, Baba H
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Journal Title
Ann Surg Oncol 19 Suppl
Volume: 3
Issue: S3
Pages: 656-64
DOI
Related Report
Peer Reviewed
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[Presentation] 胃癌におけるmicroRNA-200bによる癌浸潤転移の制御機構2011
Author(s)
蔵重淳二, 渡邊雅之, 木下浩一,斎藤誠哉,佐藤伸隆,辛島龍一,平島浩太郎,日吉幸晴,岩槻政晃,蒲原英伸,林尚子,馬場秀夫
Organizer
第111回日本外科学会定期学術集会
Place of Presentation
震災の為、紙面発表(東京)
Related Report
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[Presentation] 食道癌予後因子としてのmiR-29cの発現の意義2011
Author(s)
木下浩一,蒲原英伸,田中洋平, 蔵重淳二,斎藤誠哉 ,辛島龍一,平島浩太郎,佐藤伸隆,今村裕,,長井洋平,岩上志朗伸,林尚子,渡邊雅之,,馬場秀夫
Organizer
第111回日本外科学会定期学術集会
Place of Presentation
震災の為、紙面発表(東京)
Related Report
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