| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Aim of this study is to clarify the mechanism of cytomegalovirus (CMV) reactivation after organ transplantation. For this purpose, we developed in vitro and in vivo CMV reactivation models. In in vitro model, two macrophage-derived cell lines were used, and then the cell differentiation and acetylation of histone in CMV infected cells were demonstrated to be critical in CMV reactivation. In in vivo model, we demonstrated the CMV reactivation in the milk of breast-feeding female mice. Interestingly, reactivated CMV titers in the breast milk was much higher in syngeneic pregnancy than those in allogeneic pregnancy, suggesting that allogeneic stimuli is unnecessary in CMV reactivation.
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