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Development of Endothelialized artificial small caliper graft

Research Project

Project/Area Number 23591878
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

SAITO SATOSHI  東京女子医科大学, 医学部, 講師 (60246551)

Co-Investigator(Kenkyū-buntansha) MATSUMURA Goki  東京女子医科大学, 医学部, 准講師 (20297469)
UMEHARA Nobuhiro  東京女子医科大学, 医学部, 助教 (90349746)
小沼 武司  三重大学, 医学部附属病院, 講師 (40307559)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords再生医療 / 生体吸収性素材 / 再生医学 / 小口径血管 / 組織工学 / 自己組織化 / 血管再生 / 小口径人工血管
Outline of Final Research Achievements

This study was planned to develop a novel small caliber artificial graft without late-term thrombo-embolic complication using tissue engineering techniques. The final goal was to combine the biodegradable scaffold into the internal surface of the artificial graft, which has the potential to induce the autologous tissue such as endothelial cells. To accomplish the purpose of the study, we first developed approximately three mm-small caliper bioabsorbable conduit created with non-woven fabric sheet for cell engraftment, and a film for avoiding blood leakage. The patency of the graft and tissue generation was examined in the carotid artery of the experimental animal. However, as excess colt formation was observed in the conduit, we decided to explore the better biodegradable materials to generate biological surface. The study is now in progress.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) (of which Invited: 4 results)

  • [Journal Article] A new tissue-engineered biodegradable surgical patch for high-pressure systems2015

    • Author(s)
      Ichihara, Y. Shinoka, T. Matsumura, G. Ikada, Y. Yamazaki, K.
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: online Issue: 6 Pages: 768-776

    • DOI

      10.1093/icvts/ivv017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histological maturation of vascular smooth muscle cells in in situ tissue-engineered vasculature2014

    • Author(s)
      Noriko Isayama, Goki Matsumura, et al.
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 11 Pages: 3589-3595

    • DOI

      10.1016/j.biomaterials.2014.01.006

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Post-approval study of a highly pulsed, low-share-rate, continuous-flow, left ventricular assist device, EVAHEART: A Japanese multicenter study using J-MACS2014

    • Author(s)
      Saito S, Yamazaki K, Nishinaka T, Ichihara Y, Ono M, Kyo S, Nishimura T, Nakatani T, Toda K, Sawa Y, Tominaga R, Tanoue T, Saiki Y, Matsui Y, Takemura T, Niinami H, Matsumiya G; J-MACS Research Group.
    • Journal Title

      JOURNAL OF HEART AND LUNG TRANSPLANTATION

      Volume: In press Issue: 6 Pages: 599-608

    • DOI

      10.1016/j.healun.2014.02.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of Vascular Smooth Muscle Cells in Canine Great Vessels2013

    • Author(s)
      Noriko Isayama
    • Journal Title

      BMC Veterinary Research

      Volume: 9 Issue: 1 Pages: 1-8

    • DOI

      10.1186/1746-6148-9-54

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term results of cell-free biodegradable scaffolds for in situ tissue engineering of pulmonary artery in a canine model2013

    • Author(s)
      2. Matsumura, G., Isayama, N.,Matsuda, S., Taki, K., Sakamoto, Y., Ikada, Y., Yamazaki, K.
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 27 Pages: 6422-6428

    • DOI

      10.1016/j.biomaterials.2013.05.037

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes of pediatric ventricular assist device implantation: A single-institute report from Japan.2013

    • Author(s)
      Komagamine M, Nishinaka T, Iwata Y, Tsukui Y, Saito S#, Yamazaki K.
    • Journal Title

      Int J Artif Organs.

      Volume: 36(12) Issue: 12 Pages: 887-91

    • DOI

      10.5301/ijao.5000263

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 「再生医療-幹細胞操作と工学技術からのアプローチ-」 細胞を用いずに自己の血管を再生させる人工血管2011

    • Author(s)
      松村剛毅
    • Journal Title

      人工臓器

      Volume: 40(3) Pages: 236-239

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Tissue Engineered valves and vessels: Where do we stand today?2014

    • Author(s)
      Goki Matsumura
    • Organizer
      The 5th Congress of Asia Pacific Pediatric Cardiac Society; APPCS
    • Place of Presentation
      India
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Long term Mechanical circulatory support with highly pulsed low share rate continuous flow LVAS;multicenter Japanese experience with EVAHEART2014

    • Author(s)
      Satoshi Saito
    • Organizer
      Society of Thoracic Surgeon
    • Place of Presentation
      Orland, FL,USA
    • Related Report
      2013 Research-status Report
  • [Presentation] EVAHEART; Japanese Excperience2014

    • Author(s)
      Satoshi Saito
    • Organizer
      ISHLT Annual meeting , MCS Academy
    • Place of Presentation
      Sandiego, CA, USA
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Regenerative medicine for artificial organs, Development of in-situ Tissue-Engineered Vasculature (iTEV)2013

    • Author(s)
      Goki Matsumura, Noriko Isayama, Kenji Yamazaki
    • Organizer
      JSAO / IFAO joint symposium
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Bjork Fontan 術後TCPC conversion を施行した症例の検討2012

    • Author(s)
      小沼 武司
    • Organizer
      第14回日本成人先天性心疾患学会
    • Place of Presentation
      東京,聖路加
    • Related Report
      2011 Research-status Report
  • [Presentation] 先天性心疾患大動脈便位における外科治療の適応と遠隔成績の検討2011

    • Author(s)
      小沼 武司
    • Organizer
      第47回日本小児循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 自己細胞と生体吸収性ポリマーを用いた心外導管型TCPC25例の臨床研究の遠隔成績と今後のストラテジー2011

    • Author(s)
      松村 剛毅
    • Organizer
      第47回日本小児循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 心不全における再生治療up to date2011

    • Author(s)
      松村 剛毅
    • Organizer
      第15回日本心不全学会学術集会
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Research-status Report
  • [Presentation] Tissue Engineering Vasculature using Biodegradable Scaffold:Single Center Experience of In-Vitro and In-Vivo Studies2011

    • Author(s)
      松村 剛毅
    • Organizer
      International Symposium on Regenerative Medicine/KIST-Wake Forest-KNUH Joint Symposium
    • Place of Presentation
      Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体吸収性素材による再生血管療法

    • Author(s)
      松村剛毅
    • Organizer
      第19回バイオレオロジー・リサーチ・フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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