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Development of novel therapy to control the acute rejection in organ transplantation model using the dedifferentiated fat cells(DFAT).

Research Project

Project/Area Number 23591879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionNihon University

Principal Investigator

SUGTOU kiminobu  日本大学, 医学部, 助教 (10328750)

Co-Investigator(Kenkyū-buntansha) KOSHINAGA Tugumichi  日本大学, 医学部, 教授 (70205376)
MATUMOTO Taro  日本大学, 医学部, 教授 (50366580)
IKEDA Taro  日本大学, 医学部, 助教 (00318396)
KONUMA Noriyoshi  日本大学, 医学部, その他 (50553103)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords移植・再生医療 / 再生医学 / 小児外科 / 脱分化脂肪細胞 / 免疫拒絶 / DFAT / 前駆脂肪細胞 / 皮膚移植 / 免疫抑制
Research Abstract

We examined T cell proliferation assay by co-culturing the T cells extracted from spleens of mice and mouse DFAT. In result, it was possible to suppress the proliferation of T cells in a concentration dependent of the DFAT. Then we examined for the immunosuppressive effect of DFAT in vivo. At first, establish a skin replacement transplant model and ectopic cardiac transplant model, we examined the survival prolongation of graft by DFAT administration. However, we didn't observed survival prolongation of graft by DFAT administration. Immunosuppressive effect in vitro is present, but it was found that not resulting to suppress rejection in vivo.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Presentation (3 results)

  • [Presentation] DFATのT細胞増殖抑制効果とマウス皮膚移植の急性拒絶期における免疫抑制効果2013

    • Author(s)
      細川 崇
    • Organizer
      日本大学幹細胞研究フォーラム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス皮膚移植における脱分化成熟脂肪細胞(DFAT)の免疫抑制効果2012

    • Author(s)
      小沼 憲祥
    • Organizer
      日本外科学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] DFATのT細胞増殖抑制効果とマウス皮膚移植の急性拒絶期における免疫抑制効果2012

    • Author(s)
      細川 崇
    • Organizer
      日本小児外科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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