| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To investigate the effect of PPAR-gamma (PPARg) agonist on cecal ligation and puncture (CLP)-induced adipose-tissue inflammation and lung injury in mice. Mice were assigned to 3 groups: 1) CLP group, 2) PPARg agonist-treated CLP group, or 3) sham group. PPARg agonist was injected intraperitonally for 7 days. TNF-alpha (TNF) levels in serum and peritoneal lavage fluid were significantly higher in the CLP group than in the PPARg agonist-treated CLP group. PPARg agonist treatment decreased the TNF mRNA expression levels as compared with the CLP group. Histopathological analysis of lung tissue revealed significantly increased numbers of TUNEL-positive cells in the CLP group as compared with the sham-operated control group. PPARg agonist treatment reduced the CLP-induced cell and tissue injury as compared with the CLP group. PPARg agonist effectively suggested to prevent lung injury caused by CLP-induced sepsis by maintaining the anti-inflammatory status of adipose tissue.
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