Clinical appliciation of cancer treatment by revealing alternative splicing mechanism of c-myc transcriptional suppressor FBP-interacting repressor

• Project/Area Number: 23591891
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Chiba University
• Principal Investigator: MATSUSHITA Kazuyuki 千葉大学, 医学(系)研究科(研究院), 准教授 (90344994)
• Co-Investigator(Kenkyū-buntansha): NOMURA Fumio 千葉大学, 大学院医学研究院, 教授 (80164739) ; SATOH Mamoru 千葉大学, 医学部附属病院, 寄附研究部門教員 (20401002)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: がん診断 / バイオマーカー / がん治療 / 癌治療 / c-myc / alternative splicing / cancer / SF3b1 / SAP155 / therapy / protein interaction / がん / c-myc転写調節 / ＦＩＲ / スプライシング

Research Abstract

Recently, an interaction between FBP-interacting repressor, FIR, and TFIIH/p89/XPB helicase was found to repress c-myc transcription and so might be important for sippressing tumor formation. Further, enforced expression of FIR induced apoptosis. Deletion of FIR's amino terminal repression domain rescued the
cells from apoptosis, as did co-expression of c-Myc with FIR. Thus repression of c-myc mediates FIR-driven apoptosis. A splicing variant of FIR unable to repress c-myc nor driving apoptosis was frequently discovered in human primary colorectal cancers, but not in the adjacent normal tissues. In this study, adeno- or Sendai virus FIR expression vector was examined its anti-tumor efficacy. Additionally, FIR splicing variant was detected at their protein or mRNA level in the peripheral blood of colorectal cancer patients.

Research Products

• [Journal Article] Discovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring and tissue microarray analysis. (2014)
  • Author(s): Kume H, Muraoka S, Kuga T, Adachi J, Narumi R, Watanabe S, Kuwano M, Kodera Y, Matsushita K, Fukuoka J, Masuda T, Ishihama Y, Matsubara H, Nomura F, and Tomonaga T.
  • Journal Title: Mol Cell Proteomics. Volume: -
  • Peer Reviewed
• [Journal Article] Change in albumin measurement method affects diagnosis of nephrotic syndrome. (2014)
  • Author(s): Seimiya M, Ohno S, Asano H, Fujiwara K, Yoshida T, Sawabe Y, Sogawa K, Ogawa M, Matsushita K, Takizawa H, Yokosuka O, Nomura F.
  • Journal Title: Clinical Laboratory Volume: -
  • Peer Reviewed
• [Journal Article] Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation. (2014)
  • Author(s): Kuga T, Nie H, Kazami T, Satoh M, Matsushita K, Nomura F, Maeshima K, Nakayama Y, Tomonaga T.
  • Journal Title: Oncogenesis. Volume: -
  • Peer Reviewed
• [Journal Article] Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy. (2014)
  • Author(s): Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, and Nomura F.
  • Journal Title: World J of Gastroenterology. Volume: -
  • Peer Reviewed
• [Journal Article] Human apolipoprotein E resequencing by proteomic analysis and its application to serotyping. (2014)
  • Author(s): Nishimura M, Satoh M, Nishimura S, Kakinuma S, Sato K, Sawai S, Matsushita K, Kado S, Kodera Y, Nomura F.
  • Journal Title: PLoS One. Volume: - Issue: 1 Pages: e85356-e85356
  • DOI: 10.1371/journal.pone.0085356
  • Peer Reviewed / Open Access
• [Journal Article] Transbronchial biopsy needle rinse solution used for comprehensive biomarker testing in patients with lung cancer. (2014)
  • Author(s): Sakairi Y, Sato K, Itoga S, Saegusa F, Matsushita K, Nakajima T, Yoshida S, Takiguchi Y, Nomura F, Yoshino I.
  • Journal Title: J Thorac Oncol. Volume: 9(1) Issue: 1 Pages: 26-32
  • DOI: 10.1097/jto.0000000000000024
  • Peer Reviewed
• [Journal Article] Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway (2013)
  • Author(s): Rahmutulla B, Matsushita K, Satoh M, Seimiya M, Tsuchida S, Kubo S, Shimada H, Otsuka M, Miyazaki M, and Nomura F
  • Journal Title: Oncotarget
  • URL: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=1650
  • Peer Reviewed
• [Journal Article] SAP155-mediated c-myc suppressor FBP-interacting repressor splicing variants are activated in colon cancer tissues (2013)
  • Author(s): Kajiwara T, Matsushita K, Itoga S, Tamura M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Habara Y, Matsuo M, Nomura F
  • Journal Title: Cancer Sci Volume: 104(2) Issue: 2 Pages: 149-156
  • DOI: 10.1111/cas.12058
  • Peer Reviewed
• [Journal Article] Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression. (2013)
  • Author(s): Matsushita K, Tamura M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Levens D, He L, Liu J, Yoshida M, and Nomura F.
  • Journal Title: Mol Cancer Res. Volume: 11 Issue: 7 Pages: 689-98
  • DOI: 10.1158/1541-7786.mcr-12-0673
  • Peer Reviewed
• [Journal Article] Child-pugh score is altered by the albumin measurement method (2013)
  • Author(s): Seimiya M, Ohno S, Yamamoto H, Fujiwara K, Yoshida T, Sawabe Y, Sogawa K, Matsushita K, Yokosuka O, Nomura F
  • Journal Title: Hepatology Volume: 57(5) Issue: 5 Pages: 2093-4
  • DOI: 10.1002/hep.25972
  • Peer Reviewed
• [Journal Article] Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease. (2013)
  • Author(s): Tsuchida S, Satoh M, Kawashima Y, Sogawa K, Kado S, Sawai S, Nishimura M, Ogita M, Takeuchi Y, Kobyashi H, Aoki A, Kodera Y, Matsushita K. Izumi Y. Nomura F
  • Journal Title: Proteomics Volume: Vol.13 Issue: 15 Pages: 2339-2350
  • DOI: 10.1002/pmic.201200510
  • Peer Reviewed
• [Journal Article] Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway. (2013)
  • Author(s): Rahmutulla B, Matsushita K, Satoh M, Seimiya M, Tsuchida S, Kubo S, Shimada H, Otsuka M, Miyazaki M, and Nomura F.
  • Journal Title: Oncotarget Volume: -
  • Peer Reviewed
• [Journal Article] The Japanese Society of Laboratory Medicine (JSLM), The Committee for Standardization, Japan. Evaluation of various storage conditions of laboratory testing samples. (2013)
  • Author(s): Furuta K, Hashiguchi T, Hidaka Y, Kang D, Ikeda K, Maekawa M, Matsumoto H, Matsushita K, Okubo S, Tsuchiya T.
  • Journal Title: Cryobiology Volume: - Pages: 439-440
  • Peer Reviewed
• [Journal Article] he FLS (Fatty liver Shionogi) mouse reveals local expressions of lipocalin-2, CXCL1 and CXCL9 in the liver with non-alcoholic steatohepatitis. (2013)
  • Author(s): Semba T, Nishimura M, Nishimura S, Ohara O, Ishige T, Ohno S, Nonaka K, Sogawa K, Satoh M, Sawai S, Matsushita K, Imazeki F, Yokosuka O, Nomura F.
  • Journal Title: BMC Gastroenterol. Volume: 13 Issue: 1 Pages: 120-127
  • DOI: 10.1186/1471-230x-13-120
  • Peer Reviewed
• [Journal Article] Clathrin heavy chain is a useful immunohistochemical marker for esophageal squamous intraepithelial neoplasia. (2013)
  • Author(s): Tokita K, Seimiya M, Matsushita K, Tomonaga T, Onodera K, Ohki S, Tohru T, Uesato M, Shimada H, Matsubara H, Nakatani Y, Nomura F.
  • Journal Title: Esophagus Volume: - Issue: 4 Pages: 1-6
  • DOI: 10.1007/s10388-013-0381-9
  • NAID: 40019956893
  • Peer Reviewed
• [Journal Article] Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease. (2013)
  • Author(s): Tsuchida S, Satoh M, Kawashima Y, Sogawa K, Kado S, Sawai S, Motoi N, Ogita M, Takeuchi Y, Kobyashi H, Aoki A, Kodera Y, Matsushita K, Izumi Y, Nomura F.
  • Journal Title: Proteomics Volume: 13 Pages: 2339-2350
  • Peer Reviewed
• [Journal Article] SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression (2012)
  • Author(s): Matsushita, K., Kajiwara, T., Tamura, M., Satoh, M., Tanaka, N., Tomonaga, T., Matsubara, H., Shimada, H., Yoshimoto, R., Ito, A., Kubo, S., Natsume, T., Levens, D., Yoshida, M., and Nomura, F
  • Journal Title: Mol. Cancer Res Volume: 10 Issue: 6 Pages: 787-799
  • DOI: 10.1158/1541-7786.mcr-11-0462
  • Peer Reviewed
• [Journal Article] Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma (2012)
  • Author(s): Nomura F, Sogawa K, Noda K, Seimiya M, Matsushita K, Miura T, Tomonaga T, Yoshitomi H, Imazeki F, Takizawa H, Mogushi K, Miyazaki M, Yokosuka O
  • Journal Title: Biochem Biophys Res Commun Volume: 421(4) Issue: 4 Pages: 837-43
  • DOI: 10.1016/j.bbrc.2012.04.099
  • Peer Reviewed
• [Journal Article] Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers. (2012)
  • Author(s): Tsuchida S
  • Journal Title: Proteomics. Volume: 12(13) Issue: 13 Pages: 2190-202
  • DOI: 10.1002/pmic.201100655
  • Peer Reviewed
• [Journal Article] Serum cystatin C as a marker for early detection of chronic kidney disease and grade 2 nephropathy in Japanese patients with type 2 diabetes (2012)
  • Author(s): Suzuki Y, Matsushita K, Seimiya M,Yoshida T, Sawabe Y, Ogawa M, Nomura F
  • Journal Title: Clin Chem Lab Med Volume: 50(10) Issue: 10 Pages: 1833-9
  • DOI: 10.1515/cclm-2011-0777
  • Peer Reviewed
• [Journal Article] Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31. (2012)
  • Author(s): Ishige T, Sawai S, Itoga S, Sato K, Utsuno E, Beppu M, Kanai K, Nishimura M, Matsushita K, Kuwabara S, Nomura F.
  • Journal Title: J Hum Genet Volume: 57(12) Issue: 12 Pages: 807-808
  • DOI: 10.1038/jhg.2012.112
  • NAID: 10031145890
  • Peer Reviewed
• [Journal Article] Identification of a Novel Biomarker for Biliary Tract Cancer Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. (2012)
  • Author(s): Kikkawa S, Sogawa K, Satoh M, Umemura H, Kodera Y, Matsushita K, Tomonaga T, Miyazaki M, Yokosuka O, Nomura F.
  • Journal Title: Int J Proteomics Volume: 108 Pages: 609-609
  • DOI: 10.1155/2012/108609
  • Peer Reviewed
• [Journal Article] Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells (2012)
  • Author(s): Kagawa S, Takano S, Yoshitomi H, Kimura F, Satoh M, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Furukawa K, Matsushita K, Nomura F, Miyazaki M
  • Journal Title: T Surg Res Volume: 178 Issue: 2 Pages: 758-767
  • DOI: 10.1016/j.jss.2012.05.065
  • Peer Reviewed
• [Journal Article] SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression. (2012)
  • Author(s): Matsushita K, Kajiwara T, Tamura M, Satoh M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Yoshimoto R, Ito A, Kubo S, Natsume T, Levens D, Yoshida M, Nomura F.
  • Journal Title: Mol Cancer Res Volume: 10(6) Pages: 787-799
  • Peer Reviewed
• [Journal Article] High-Resolution Melting Analyses for Gene Scanning of APC, MLH1, MSH2, and MSH6 Associated with Hereditary Colorectal Cancer. (2012)
  • Author(s): Obul J, Itoga S, Abliz M, Sato K, Ishige T, Utsuno E, Matsushita K, Matsubara H, Nomura F.
  • Journal Title: Genet Test Mol Biomarkers. Volume: in press
  • Peer Reviewed
• [Journal Article] Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma. (2012)
  • Author(s): Katada K, Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, Hanazawa T, Nomura F, Okamoto Y.
  • Journal Title: J Proteomics. Volume: 75(6) Pages: 1803-15
  • Peer Reviewed
• [Journal Article] Recent advancement of esophageal cancer gene therapy (2011)
  • Author(s): Yajima S, Oshima Y, Shimada H, Matsushita K, Tagawa M.
  • Journal Title: Nihon Rinsho. Volume: Suppl 6 Pages: 387-91
  • NAID: 10024306785
  • Peer Reviewed
• [Journal Article] Abulaizi M, Tomonaga T, Satoh M, Sogawa K, Matsushita K, Kodera Y, Obul J, Takano S, Yoshitomi H, Miyazaki M, Nomura F. (2011)
  • Author(s): The application of a three-step proteome analysis for identification of new biomarkers of pancreatic cancer.
  • Journal Title: Int J Proteomics Volume: 628787. Pages: 1-13
  • DOI: 10.1155/2011/628787
  • Peer Reviewed
• [Journal Article] Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells. (2011)
  • Author(s): Tonoike Y, Matsushita K, Tomonaga T, Katada K, Tanaka N, Shimada H, Nakatani Y, Okamoto Y, Nomura F.
  • Journal Title: BMC Cell Biol Volume: 12 Pages: 41-41
  • Peer Reviewed
• [Journal Article] w peritoneal and systemic inflammatory response after laparoscopy-assisted gastrectomy compared to open gastrectomy. (2011)
  • Author(s): Natsume T, Kawahira H, Hayashi H, Nabeya Y, Akai T, Horibe D, Shuto K, Akutsu Y, Matsushita K, Nomura F, Matsubara H.
  • Journal Title: Hepatogastroenterology Volume: 58(106) Pages: 659-62
  • Peer Reviewed
• [Journal Article] Clinical validity of renal function markers including serum cystatin C on chronic kidney disease classification (2011)
  • Author(s): Suzuki Y, Matsushita K, Yoshida T, Sawabe Y, Nomura F.
  • Journal Title: Rinsho Byori Volume: 59(4) Pages: 345-51
  • NAID: 10029427259
  • Peer Reviewed
• [Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesothelioma. (2011)
  • Author(s): Kitamura A, Matsushita K, Takiguchi Y, Shimada H, Tada Y, Yamanaka M, Hiroshima K, Tagawa M, Tomonaga T, Matsubara H, Inoue M, Hasegawa M, Sato Y, Levens D, Tatsumi K, Nomura F.
  • Journal Title: Cancer Sci Volume: 102(7) Pages: 1366-73
  • NAID: 10029295478
  • Peer Reviewed
• [Presentation] 当院におけるリンチ症候群に対するMSI (microsatellite instability)検査の立ち上げについて (2013)
  • Author(s): 松下一之、糸賀栄、宮内英聡、鈴木一史、太田聡、中谷行雄、松原久裕、野村文夫
  • Organizer: 先端応用外科例会
  • Place of Presentation: 千葉
  • Year and Date: 2013-12-02
• [Presentation] SAP155-mediated c-myc suppressor FBP-interacting repressor splicing variants as colon cancer screening biomarkers (2013)
  • Author(s): Kajiwara T, Matsushita K, Itoga S, Nomura F
  • Organizer: Am Assoc Clinical Chem
  • Place of Presentation: Houston, USA
  • Year and Date: 2013-07-30
• [Presentation] 大腸癌新規腫瘍マーカー候補:末梢血中のc-myc転写抑制因子FIRのスプライシングバリアントFIRΔexon2 mRNAの検出。A novel diagnostic value of splicing variant form of c-myc transcriptional repressor FUSE-Binding protein-Interacting repressor for colorectal cancers (2013)
  • Author(s): 松下一之、石塚寿子、糸賀栄、野村文夫
  • Organizer: 第20回日本遺伝子診療学会
  • Place of Presentation: 浜松
  • Year and Date: 2013-07-18
• [Presentation] SAP155とFUSE-binding protein-interacting repressorの相互作用は細胞周期と増殖をリンクする (2013)
  • Author(s): 松下一之、吉田稔、長田裕之、野村文夫
  • Organizer: 日本がん分子標的治療研究会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2013-06-14
• [Presentation] Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression revealed by GeLC-MS approach (2013)
  • Author(s): Matsushita K, Satoh M, Tomonaga T and Nomura F
  • Organizer: Human Proteome Organization (HUPO)
  • Place of Presentation: Yokohama
• [Presentation] SAP155と FUSE-binding protein-interacting repressor の相互作用は細胞周期と増殖をリンクする (2013)
  • Author(s): 松下 一之、吉田 稔、長田裕之、野村 文夫
  • Organizer: 日本がん分子標的治療研究会
  • Place of Presentation: 京都
• [Presentation] RCA1 変異陽性HBOCに対してリスク低減予防的両側卵巣卵管全摘出術を施行し卵管漿液性上皮内腺癌（STIC）を認めた一例 (2013)
  • Author(s): 松下一之、宇津野恵美、石川博士、糸賀 栄、長田久夫、長嶋 健、西村 基、澤井 摂、楯 真一、清川貴子、高橋葉子、太田 聡、中谷行雄、生水真紀夫、野村文夫
  • Organizer: 第37回日本遺伝カウンセリング学会
  • Place of Presentation: 川崎
• [Presentation] SAP155-mediated c-myc suppressor FBP-interacting repressor splicing variants as colon cancer screening biomarkers (2013)
  • Author(s): Kajiwara T, Matsushita K, Itoga S, Nomura F
  • Organizer: Am Assoc Clinical Chem.
  • Place of Presentation: Houston, USA
• [Presentation] Highly sensitive detection of EGFR mutations using Bronchoscopic Ultra-Micro Sampling in patients with Non-Small Cell Lung Cancer (NSCLC). (2013)
  • Author(s): Sato K, Itoga S, Sakairi Y, Ishige T, Matsushita K, Yoshino I, Nomura F
  • Organizer: Am Assoc Clinical Chem.
  • Place of Presentation: Houston, USA
• [Presentation] High-throughput screening of ALK, RET, and ROS1 fusion transcripts in non-small cell lung cancer (NSCLC) by multiplex real-time RT-PCR high-resolution melting curve analysis (2013)
  • Author(s): Itoga S, Sato K, Sakairi Y, Ishige T, Matsushita K, Yoshino I, Nomura F
  • Organizer: Am Assoc Clinical Chem.
  • Place of Presentation: Houston, USA
• [Presentation] 大腸癌新規腫瘍マーカー候補：末梢血中のc-myc転写抑制因子FIRのスプライシングバリアントFIRΔexon2 mRNAの検出 (2013)
  • Author(s): 松下一之、石塚寿子、糸賀 栄、野村文夫
  • Organizer: 第20回日本遺伝子診療学会
  • Place of Presentation: 浜松
• [Presentation] 臨床検体の網羅的な保存（いわゆるバイオバンク）による医学研究支援についてー検査部からみた臨床検体の精度管理・保存法の標準化の必要性ー (2013)
  • Author(s): 松下一之、澤部祐司、野村文夫
  • Organizer: 日本臨床検査自動化学会第４５回大会
  • Place of Presentation: 横浜
• [Presentation] リスク低減両側卵巣卵管全摘出術を施行し右卵管漿液性上皮内腺癌（STIC）を認めたBRCA1遺伝子変異陽性HBOCの一例 (2013)
  • Author(s): 松下一之、石川博士、長嶋 健、清川貴子、中谷 行雄、生水真紀夫、野村文夫
  • Organizer: 日本人類遺伝学会第５８回大会
  • Place of Presentation: 仙台
• [Presentation] 千葉大学病院におけるLynch症候群に対するMSI（microsatellite instability）検査の立ち上げについて (2013)
  • Author(s): 松下一之、佐藤 謙一、石毛崇之、糸賀 栄、野村文夫
  • Organizer: 日本臨床検査医学会総会
  • Place of Presentation: 神戸
• [Presentation] 当院におけるリンチ症候群に対するMSI (microsatellite instability) 検査の立ち上げについて (2013)
  • Author(s): 松下一之、糸賀 栄、宮内英聡、鈴木一史、太田 聡、中谷行雄、松原久裕、野村文夫
  • Organizer: 先端応用外科例会
  • Place of Presentation: 千葉
• [Presentation] Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression. (2013)
  • Author(s): Kazuyuki Matsushita, Minoru Yoshida, Mamoru Satoh, Hisahiro Matsubara, Hideaki Shimada, Takeshi Tomonaga , Fumio Nomura.
  • Organizer: 72st JCA meeting.
  • Place of Presentation: Yokohama
• [Presentation] ApoE (Apolipoprotein E) typing from small amounts of blood samples (2013)
  • Author(s): Motoi Nishimura, Satomi Nishimura, Mamoru Satoh, Shoko Kakinuma, Kenichi Satoh, Setsu Sawai, Kazuyuki Matsushita, Sayaka Kado, Yoshio Kodera, Fumio Nomura
  • Organizer: MSACL 2013
  • Place of Presentation: San Diego, CA, USA
• [Presentation] c-myc転写抑制因子FIR splicing variant検出による大腸癌診断・治療への応用 (2012)
  • Author(s): 松下一之、石塚寿子、糸賀栄、野村文夫
  • Organizer: 59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都
• [Presentation] c-myc遺伝子転写抑制因子FIRとスプライシング因子SAP155の結合による新規がん化メカニズムについて(international session) (2012)
  • Author(s): 松下一之、石塚寿子、佐藤守、松原久裕、島田英昭、朝長毅、久保秀司、吉田稔、野村文夫
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] SAP155-mediated splicing of FUSE-binding protein-interacting repressor (FIR) serves as a molecular switch for c-myc gene expression (2012)
  • Author(s): Matsushita K, Kajiwara T, Satoh M, Tomonaga T, Matsubara H, Shimada H, Yoshida M, and Nomura F
  • Organizer: 2nd Japan-China Symposium on Cancer Research JCSCR2012
  • Place of Presentation: 幕張
• [Presentation] 治療抵抗性固形癌の克服のための臨床検体を用いた病態解析の取り組み (2012)
  • Author(s): 松下一之、松原久裕、宮崎勝、野村文夫
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張
• [Presentation] 治療抵抗性固形癌の克服のための臨床検体を用いた病態解析の取り組み． (2012)
  • Author(s): 松下 一之 , 松原 久裕 , 宮崎 勝 , 野村 文夫．
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 東京（震災のため誌上開催）
• [Presentation] 血清タンパク質よりの Apolipoprotein E (ApoE) タイピング (2012)
  • Author(s): 西村基、西村里美、佐藤守、澤井摂 、柿沼翔子、佐藤謙一、松下一之、小寺義男、野村文夫
  • Organizer: 日本人類遺伝学会 第57回大会
  • Place of Presentation: 幕張
• [Presentation] 歯肉溝滲出液のプロテオーム解析による歯周疾患マーカーの探索. (2012)
  • Author(s): 土田 祥央、佐藤 守、曽川 一幸、川島 祐介、荷堂 清香、澤井 摂、西村 基、小寺 義男、松下 一之、野村 文夫.
  • Organizer: 第19回日本遺伝子診療学会大会
  • Place of Presentation: 千葉
• [Presentation] SAP155-mediated splicing of FUSE-binding protein-interacting repressor (FIR) serves as a molecular switch for c-myc gene expression. (2012)
  • Author(s): 234. Kazuyuki Matsushita, Toshiko Kajiwara, Mamoru Satoh, Takeshi Tomonaga, Hisahiro Matsubara, Hideaki Shimada, Minoru Yoshida, and Fumio Nomura.
  • Organizer: 2nd Japan-China Symposium on Cancer Research JCSCR2012
  • Place of Presentation: 千葉
• [Presentation] 重粒子線治療の晩期障害に対する遺伝子治療を用いた予防対策． (2012)
  • Author(s): 松下 一之、加野将之、山田 滋、島田英昭、松原久裕、野村文夫
  • Organizer: NIRSテクノフェア
  • Place of Presentation: 千葉
• [Presentation] c-myc遺伝子転写抑制因子FIRとスプライシング因子SAP155の結合による新規がん化メカニズムについて (2012)
  • Author(s): 236. 松下 一之、 石塚 寿子、 佐藤 守、 松原 久裕、 島田 英昭、 朝長 毅、 久保 秀司、 吉田 稔、 野村 文夫
  • Organizer: 第７１回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] リスク低減両側卵巣卵管全摘出術を施行し右卵管漿液性上皮内腺癌（STIC）を認めたBRCA1遺伝子変異陽性HBOCの一例
  • Author(s): 松下一之、宇津野恵美、小原令子、石川博士、長嶋 健、清川貴子、中谷 行雄、生水真紀夫、野村文夫
  • Organizer: 第１９回日本家族性腫瘍学会学術集会
  • Place of Presentation: 別府
• [Presentation] 消化器癌の臨床検体を用いた有機的基礎研究システム構築への取り組み
  • Author(s): 松下一之、松原久裕、宮崎 勝、野村文夫
  • Organizer: 第111回日本外科学会総会
  • Place of Presentation: 東京国際フォ-ラム（震災のため誌上発表）
• [Presentation] c-myc遺伝子転写抑制因子FIRはSAP155によりスプライシング変化を受けc-Mycの発現
  • Author(s): 松下一之、梶原寿子、島田英昭、松原久裕、吉田 稔、野村文夫他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋市
• [Presentation] 臨床検体（血清・血漿）の品質評価法と有機的研究システム構築の取り組み
  • Author(s): 松下一之、野村文夫
  • Organizer: 日本自動化学会
  • Place of Presentation: 横浜市
• [Presentation] 千葉大学病院における長期臨床検体（DNA・RNA・血清・血漿）保存のための品質標準化・評価法確立の取り組み
  • Author(s): 松下一之、松原久裕、宮崎 勝、野村文夫
  • Organizer: 人類遺伝学会
  • Place of Presentation: 幕張
• [Presentation] Standardization and quality control of sera samples of biobanking for gastrointestinal cancers
  • Author(s): Matsushita K, Nomura F
  • Organizer: Leaders in Biobanking Congress 2011
  • Place of Presentation: New Brunswick (NJ, USA)
• [Book] 「内科」増大号。RAS遺伝子 (2013)
  • Author(s): 佐藤謙一、松下一之、野村文夫
  • Total Pages: 2
  • Publisher: 南江堂
• [Book] 「内科」増大号。P53遺伝子 (2013)
  • Author(s): 松下一之、糸賀 栄、野村文夫
  • Total Pages: 2
  • Publisher: 南江堂
• [Book] 「内科」増大号。サイトケラチン19mRNA遺伝子 (2013)
  • Author(s): 石毛崇之、松下一之
  • Total Pages: 2
  • Publisher: 南江堂
• [Book] 「内科」増大号。EGFR遺伝子 (2013)
  • Author(s): 佐藤謙一、松下一之、野村文夫
  • Total Pages: 2
  • Publisher: 南江堂
• [Book] 「内科」増大号。ALK融合遺伝子 (2013)
  • Author(s): 糸賀 栄、松下一之、野村文夫
  • Total Pages: 2
  • Publisher: 南江堂
• [Book] 「内科」増大号。c-Kit遺伝子 (2013)
  • Author(s): 松下一之、野村文夫
  • Total Pages: 2
  • Publisher: 南江堂
• [Book] 「内科」増大号。マイクロサテライト不安定性（MSI）遺伝子。 (2013)
  • Author(s): 松下一之、野村文夫
  • Total Pages: 2
  • Publisher: 南江堂
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Remarks] 千葉大学大学院医学研究院分子病態解析学
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Remarks] 千葉大学 大学院医学研究院 分子病態解析学ホームページ
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Patent(Industrial Property Rights)] がん細胞特異的なスプライシング阻害方法とスプライシング阻害剤 (2012)
  • Inventor(s): 千葉大学
  • Industrial Property Rights Holder: 千葉大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-048422
  • Filing Date: 2012-04-01
• [Patent(Industrial Property Rights)] 癌の予防剤および／または治療剤 (2012)
  • Inventor(s): 松下一之他
  • Industrial Property Rights Holder: 国立大学法人千葉大学
  • Industrial Property Number: 2012-048422
  • Filing Date: 2012