| Project/Area Number |
23591892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Masaru 千葉大学, 大学院医学研究科, 教授 (70166156)
KIMURA Fumio 千葉大学, 大学院医学研究科, 特任教授 (70334208)
OHTSUKA Masayuki 千葉大学, 大学院医学研究科, 講師 (90334185)
TAKAYASHIKI Tsukasa 千葉大学, 医学部附属病院, 助教 (30456024)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫栄養療法 / immunonutrition / 膵頭十二指腸切除術 / 肝切除 / 胆管癌 / レゾルビン / EPA / 代謝栄養外科学 |
|---|
| Research Abstract |
We performed two randomized controlled trials to investigate the effects of immunonutrition on postoperative complications after severely stressful surgery.
As the results, preoperative immunonutrition for patients undergoing pancreaticoduodenectomy and major hepatectomy could reduce infectious complication rates. It was suggested that immunonutrition modulated prostaglandin E2 production and T cell differentiation and resolvin E1 might play a key role in the resolution of acute inflammation when immunonutrition was supplemented with eicosapentaenoic acid.
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