comprehensive breast cancer therapy targeting both estrogen receptor and Hedgehog signaling pathways
| Project/Area Number |
23591895
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TANAKA Haruo 九州大学, 医学(系)研究科(研究院), 助教 (90585746)
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| Co-Investigator(Kenkyū-buntansha) |
KATANO Mitsuo 九州大学, 大学院医学研究院, 教授 (10145203)
ONISHI Hideya 九州大学, 大学院医学研究院, 准教授 (30553276)
NAKANO Kenji 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061)
SHIRAHANE Kengo 九州大学, 大学院医学研究院, 共同研究員 (10529803)
SOHZAKI Masae 九州大学, 大学病院, 医員 (40610613)
KUBO Makoto 九州大学, 大学病院, 助教 (60403961)
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|---|
| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 乳癌 / エストロゲンレセプター / Hedgehogシグナル / 癌幹細胞 / 包括的乳癌治療法 / ヘッジホッグシグナル / CD24分子 / 浸潤能 / 増殖能 / 腫瘍形成能 / エストロゲンレセプターシグナル / 乳がん / 治療標的 / Estrogen receptor経路 / Hedgehog経路 |
|---|
| Research Abstract |
Tumorigenesis and proliferation in breast canecr stem cell population; CD44+CD24- cells were higher than those in CD44+CD24+ cells. Hedgehog inhibitor treatment significantly abrogated these increases. Invasiveness, colony formation, and expressions of Shh and Gli1 in CD24 siRNA transfected cells were significantly higher than those in control. Shh suppression in CD24 siRNA transfected cells significantly reduced tumorigenesis and proliferation.
ERa pathway plays an important role for Hh signaling activation, suggesting that ER pathway contributes to the progression in breast cancer.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] NOTCH4 is a potential therapeutic target for gallbladder cancer2014
Author(s)
Nagamatsu I, Onishi H, Matsushita S, Kubo M, Kai M, Imaizumi A, Nakano K, Hattori M, Oda Y, Tanaka M, Katano M
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Journal Title
Anticancer Res
Volume: 34(1)
Pages: 69-80
URL
Related Report
Peer Reviewed
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[Journal Article] NOTCH4 is a potential therapeutic target for triple-negative breast cancer.2014
Author(s)
Nagamatsu I, Onishi H, Matsushita S, Kubo M, Kai M, Imaizumi A, Nakano K, Hattori M, Oda Y, Tanaka M, Katano M.
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Journal Title
Ａｎｔｉｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ
Volume: 34（1）
Pages: 69-80
Related Report
Peer Reviewed
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