Elucidation and examination of the role and the clinical meaning of mesenchymal stem cells (MSC) in breast cancer distant metastases.
| Project/Area Number |
23591897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIRAHANE KENGO 九州大学, 医学(系)研究科(研究院), 共同研究員 (10529803)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masao 九州大学, 医学研究院, 教授 (30163570)
OHTSUKA Takao 九州大学, 大学病院, 助教 (20372766)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳癌 / 間葉系幹細胞(MSC) / 間質増生(desmoplasia) / 癌間質相互作用 / 間葉系幹細胞 / 間様系幹細胞 |
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| Research Abstract |
In this study, MSC relating with the chemotherpy resistance and distant metastases of a breast cancer was evaluated, and the aim of this study was to create the new strategy for breast cancer. First, the pancreatic cancer tissues in our laboratory were used for MSC separation. Expression analysis of many surface markers used as the marker of MSC was conducted. CD10 was expressed in 10% of mesenchymal cells and it was considered to be one of the candidates of the important antigen for identifying MSC. Although expression rates of CD105 were 95-100%, the expression rates equalized easily after isolation. CD271 positive rates was increased under co-culture with pancreatic cancer cells, and CD271 expression in mesenchymal cells was related with good prognosis.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] CD271⁺subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells2012
Author(s)
Fujiwara K, Ohuchida K, Mizumoto K, Shindo K, Eguchi D, Kozono S, Ikenaga N, Ohtsuka T, Takahata S, Aishima S, Tanaka M
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Journal Title
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Peer Reviewed
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[Presentation] 膵癌間質におけるCD90とα-SMA発現の意義2013
Author(s)
佐田政史,大内田研宙,藤原謙次,赤川進,江口大樹,小薗真吾,趙茗,崔林,大塚隆生,水元一博,田中雅夫
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡
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[Presentation] CD271+ pancreatic stellate cells are correlated with prognosis of patients with pancreatic cancer and regulated by interaction with cancer cells2012
Author(s)
Fujiwara K, Ohuchida K, Mizumoto K, Shindo K, Eguchi D, Kozono S, Ikenaga N, Ohtsuka T, Takahata S, Aishima S, Tanaka M
Organizer
International Symposium on Pancreas Cancer 2012 in Kyoto
Place of Presentation
京都
Year and Date
2012-10-06
Related Report
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[Presentation] 膵癌におけるCD271陽性膵星細胞の意義2012
Author(s)
藤原謙次,大内田研宙,進藤幸治,赤川進,江口大樹,小薗真吾,池永直樹,崔林,相島慎一,大塚隆生,高畑俊一,水元一博,小田義直,田中雅夫
Organizer
第112回日本外科学会定期学術集会
Place of Presentation
千葉
Year and Date
2012-04-13
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[Presentation] The CD271 positive rate of pancreatic stellate cells is correlated with their migration activities enhanced by co-cultured pancreatic cancer cells2011
Author(s)
Fujiwara K, Ohuchida K, Shindo K, Kozono S, Ikenaga N, Cui L, Aishima S, Nakamura M, Mizumoto K, Oda Y, Tanaka M
Organizer
The 3rd Biennial Asian-Pacific Hepato-Pancreato-Biliary Association Congress 2011
Place of Presentation
Melbourne, Australia
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