Developing pancreatic secretory trypsin inhibitor of molecular target therapy for pancreatic cancer with pancreatic secretory trypsin inhibitor antibodies.
| Project/Area Number |
23591898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
HORINO Kei 熊本大学, 医学部附属病院, 非常勤講師 (60452900)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMORI Hiroshi 熊本大学, 医学部附属病院, 非常勤診療医師 (90363514)
OHMURAYA Masaki 熊本大学, 生命資源研究・支援センター, 准教授 (60398229)
BEPPU Toru 熊本大学, 医学部附属病院, 特任教授 (70301372)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 膵癌 / PSTI / SPINK1 / 分子標的治療薬 / オートファジー / 分子標的治療 |
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| Research Abstract |
The fusion with PEG solution in the spleen cells of immunized mice and Sp2/OAg-14 cell mouse myeloma, and to confirm the presence or absence of antibody production in two weeks after the medium was replaced, it was trial and error the production of antibodies, but because it was bogged down in hybridoma create , was administered to 8 times intraperitoneally 8 weeks antigen (PSTI) to female Balb / C mice were subjected to experiments with PSTI existing monoclonal antibodies that were sensitized. Is allowed to induce pancreatitis in the administration of a single, severity was only varies with the dose.
As a new function of SPINK, proceeded under study may be involved in growth promotion of pancreatic cancer via autophagy control, but woven transient in a single dose as human PSTI monoclonal antibodies - the Tofaji it was only acknowledge hyperactivity.
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Report
(4 results)
Research Products
(59 results)
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[Presentation] 当院における輸血マニュアルに準じた膵頭十二指腸切除術時の輸血の現況 / Perioperative blood transfusion followed the manual in the pancreaticoduodenectomy2011
Author(s)
堀野 敬、高森啓史, 田中 洋, 中原 修, 阿部 真也, 徳永 竜馬, 小澄 敬祐, 宮田 辰徳, 古橋 聡, 増田 稔郎, 近本 亮, 別府 透, 馬場 秀夫
Organizer
第111回日本外科学会定期学術集会
Place of Presentation
紙上発表
Related Report
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