Estrogen receptor positive breast cancer risk score constructed by genetic factors and endogenous hormones

• Project/Area Number: 23591901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya City University
• Principal Investigator: YOSHIMOTO Nobuyasu 名古屋市立大学, 医学(系)研究科(研究院), 助教 (10551244)
• Co-Investigator(Kenkyū-buntansha): YAMASHITA Hiroko 名古屋市立大学, 大学院医学研究科, 准教授 (70332947) ; TOYAMA Tastuya 名古屋市立大学, 大学院医学研究科, 准教授 (30315882)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: エストロゲンレセプター陽性乳癌 / リスクモデル / 一塩基多型 / 血清ホルモン / エストロゲン依存性乳癌 / 遺伝子多型 / 血清バイオマーカー / エストロゲンレセプター陽性乳癌罹患モデル

Research Abstract

To identify estrogen receptor breast cancer high risk group, we analyzed datas both estrogen receptor positive breast cancer patients and control women. We analyzed epidemiological factors, single nucleotide polymorphism and serum biomarker both ER positive breast cancer patients and control women. We constructed ER positive breast cancer risk model among both premenopausal women and postmenopausal women by logistic regression analysis.

Research Products

• [Journal Article] Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women (2011)
  • Author(s): Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H
  • Journal Title: Cancer Science Volume: 102 Issue: 11 Pages: 2065-72
  • DOI: 10.1111/j.1349-7006.2011.02047.x
  • NAID: 10030245302
  • Peer Reviewed
• [Presentation] Genetic polymorphism of estrogen metabolizing enzyme CYP17A1 rs743572 impacts on serum testosterone level in Japanese premenopausal women (2013)
  • Author(s): Yoshimoto N, Nishiyama T, Yamashita H, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Hato Y, Fujii Y, Toyama T
  • Organizer: 36th Annual Breast Cancer Symposium
  • Place of Presentation: San Antonio
  • Year and Date: 2013-12-13
• [Presentation] Genetic polymorphism of estrogen metabolizing enzyme CYP17A1 rs743572 impacts on serum testosterone level (2013)
  • Author(s): Yoshimoto N, Nishiyama T, Yamashita H, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Fujii Y, Toyama T
  • Organizer: 36th Annual San Antonio Breast Cancer Symposium
  • Place of Presentation: San Antonio, TX, USA
• [Presentation] A mammographic density prediction model using environment factors, endogenous hormones and growth factors in Japanese women (2012)
  • Author(s): Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Fujii Y, Yamashita H
  • Organizer: 35th Annual San Antonio Breast Cancer Symposium
  • Place of Presentation: San Antonio
  • Year and Date: 2012-12-06
• [Presentation] 日本乳癌学会研究奨励賞受賞者講演 エストロゲンレセプター陽性乳癌の発症メカニズムと生物学的特性に関する研究 (2012)
  • Author(s): 吉本信保
  • Organizer: 第20回日本乳癌学会
  • Place of Presentation: 熊本市民会館（熊本）
  • Invited
• [Presentation] A mammographic density prediction model using enviornment factors, endogeneous hormones and growth factors in Japanese women (2012)
  • Author(s): Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Fujii Y, Yamashita H
  • Organizer: 35th Annual San Antonio Breast Cancer Symposium
  • Place of Presentation: Henry B. Gonzalez Convention Center (San Antonio, USA)
• [Presentation] Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women (2011)
  • Author(s): Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H
  • Organizer: 34th Annual San Antonio Breast Cancer Symposium
  • Place of Presentation: San Antonio
  • Year and Date: 2011-12-09
• [Presentation] エストロゲンレセプター陽性乳癌の発症メカニズムと生物学的特性に関する研究 (2011)
  • Author(s): 吉本信保
  • Organizer: 第20回日本乳癌学会
  • Place of Presentation: 熊本(日本乳癌学会研究奨励賞受賞者講演)
  • Year and Date: 2011-06-28
• [Presentation] Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women (2011)
  • Author(s): Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H.
  • Organizer: 34th Anuual San Antonio Breast Cancer Symopsium
  • Place of Presentation: San Antonio, Texas, USA