Analysis of microRNAs and development of novel therapeutic strategies in breast cancer

• Project/Area Number: 23591902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Hokkaido University (2012); Nagoya City University (2011)
• Principal Investigator: YAMASHITA Hiroko 北海道大学, 北海道大学病院, 教授 (70332947)
• Co-Investigator(Kenkyū-buntansha): TOYAMA Tatsuya 名古屋市立大学, 大学院・医学研究科, 准教授 (30315882) ; YOSHIMOTO Nobuyasu 名古屋市立大学, 大学院・医学研究科, 助教 (10551244)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 乳癌 / マイクロRNA / エストロゲンレセプター

Research Abstract

Expression profiles of microRNAs and mRNAs in estrogen receptor (ER)-positive breast cancer tissue were compared between ERhigh Ki67low tumors and ERlow Ki67high tumors by microRNA and mRNA microarrays. Unsupervised hierarchical clustering analyses revealed distinct expression patterns of miRNAs and mRNAs in these groups. We identified miR-1290 and its potential targets that might be associated with characteristics of ER-positive breast cancer.

Research Products

• [Journal Article] MiR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer (2013)
  • Author(s): Endo Y
  • Journal Title: Endocr-Relat Cancer Volume: 20 Issue: 1 Pages: 91-102
  • DOI: 10.1530/erc-12-0207
  • Peer Reviewed
• [Journal Article] エストロゲンレセプター陽性乳癌におけるmicroRNAの役割に関する研究 (2012)
  • Author(s): 山下啓子、遠山竜也、吉本信保、遠藤友美
  • Journal Title: 日本内分泌・甲状腺外科学会雑誌 Volume: 29 Pages: 289-292
  • NAID: 130004600581
• [Journal Article] Distinct expressions of microRNAs that directly target estrogen receptor α in human breast cancer (2011)
  • Author(s): Yoshimoto N, Toyama T, Takahashi S, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H
  • Journal Title: Breast cancer Res Treat Volume: 130 Pages: 331-339
  • Peer Reviewed
• [Presentation] MicroRNAs and their potential targets associated with characteristics of estrogen receptor- positive breast cancer (2013)
  • Author(s): Endo Y, Toyama T, Takahashi S, Yoshimoto N, Iwasa M, Asano T, Fujii Y, Yamashita H
  • Organizer: 13th St. Gallen International Breast Cancer Conference 2013
  • Place of Presentation: Olma-Messen St Gallen, Switzerland
• [Presentation] Symposium: Breast cancer (Clinical research) Role of microRNAs in estrogen receptor-positive breast cancer (2012)
  • Author(s): Yamashita H, Toyama T, Yoshimoto N, EndoY, Takahashi S
  • Organizer: 15th International Congress on Hormonal Steroids and Hormones & Cancer (15th ICHSHC)
  • Place of Presentation: ISHIKAWA ONGAKUDO,Kanazawa
• [Presentation] Workshop: Molecular targeted cancer therapy and histochemistry Role of microRNAs in estrogen receptor α-positive breast cancer (2012)
  • Author(s): Yamashita H, Toyama T, Takahashi S, Yoshimoto N, Endo Y
  • Organizer: 14th International Congress of Histochemistry and Cytochemistry (ICHC2012)
  • Place of Presentation: KyotoInternational Conference Center ,Kyoto
• [Presentation] プレジデンシャルシンポジウムバイオロジーからみた乳癌の治療戦略エストロゲンレセプター陽性乳癌のバイオロジーに関する基礎的研究 (2012)
  • Author(s): 山下啓子、遠山竜也、吉本信保、遠藤友美、岩佐麻衣、浅野倫子、小林俊三
  • Organizer: 第20回日本乳癌学会総会
  • Place of Presentation: ホテル日航熊本(熊本)
• [Presentation] シンポジウム乳癌診療の未来エストロゲンレセプター陽性乳癌におけるmicroRNAの役割に関する研究 (2012)
  • Author(s): 山下啓子、遠山竜也、吉本信保、遠藤友美、岩佐麻衣、浅野倫子、小林俊三
  • Organizer: 第24回日本内分泌外科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
• [Presentation] Role of microRNAs in estrogen receptor-positive breast cancer (2012)
  • Author(s): Yamashita H
  • Organizer: 15th International Congress on Hormonal Steroids and Hormones & Cancer
  • Place of Presentation: 石川県立音楽堂（金沢市）
  • Invited
• [Presentation] Role of microRNAs in estrogen receptor α-positive breast cancer (2012)
  • Author(s): Yamashita H
  • Organizer: 14th International Congress of Histochemistry and Cytochemistry
  • Place of Presentation: 国立京都国際会館（京都市）
  • Invited
• [Presentation] エストロゲンレセプター陽性乳癌のバイオロジーに関する基礎的研究 (2012)
  • Author(s): 山下啓子
  • Organizer: 第20回日本乳癌学会総会
  • Place of Presentation: ホテル日航熊本（熊本市）
• [Presentation] エストロゲンレセプター陽性乳癌におけるmicroRNAの役割に関する研究 (2012)
  • Author(s): 山下啓子
  • Organizer: 第24回日本内分泌外科学会総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Invited
• [Presentation] Distinct expressions of microRNAs that directly target estrogen receptorαin human breast cancer (2011)
  • Author(s): Yamashita H, Yoshimoto N, Toyama T, Takahashi S, Sugiura H, Endo Y, Iwasa M, Fujii Y
  • Organizer: Advances in Breast Cancer Research, American Association for Cancer Research
  • Place of Presentation: San Francisco, U.S.A.