Loss of BTG2 expression in breast cancer progression
| Project/Area Number |
23591906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARA Takeshi 順天堂大学, 医学部, 准教授 (40276473)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 乳癌 / BTG2 / 転移 / 上皮間葉転換 / Lapatinib / EMT / 幹細胞 / microRNA |
|---|
| Research Abstract |
EMT plays an important role in the tumor invasion and metastases. In human breast cancer, decreased BTG2 expression correlates with metastatic recurrence and decrease in overall survival, suggesting that suppression of BTG2 plays a critical role in disease progression. To analyze the role of BTG2 in breast cancer, BTG2 expression was knocked down in mammary epithelial cells. Suppression of BTG2 enhanced the motility of cells in vitro and enhanced tumor growth and metastasis in vivo. The effects of BTG2 knockdown were mediated through activation of HER2 and HER3, leading to elevated AKT phosphorylation. Suppression of HER activation using the lapatinib abrogated the effects of BTG2 knockdown, including the increased cell migration observed in vitro and the enhancement of tumorigenesis and metastasis in vivo. These results link BTG2-dependent effects on tumor progression, and raise the possibility that targeted inhibition of this pathway may be relevant in treatment breast cancers.
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Report
(4 results)
Research Products
(28 results)
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Author(s)
Shiota S, Takekawa H, Matsumoto S, Takeda K, Nurwidya F, Yoshioka Y, Takahashi F, Hattori N, Tabira T, Motizuki H, Takahashi K.
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J Alzheimers Dis.
Volume: 37(2)
Pages: 325-33
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Journal Title
PLoS One
Volume: 9(1)
Issue: 1
Pages: e86459-e86459
DOI
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Peer Reviewed
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[Journal Article] a Kampo formula, ameliorates cancer cachexia induced by colon 26 adenocarcinoma in mice.2012
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Yae S, Takahashi F, Yae T, Yamaguchi T, Tsukada R, Koike K, Minakata K, Murakami A, Nurwidya F, Kato M, Tamada M, Yoshitake M, Kobayashi H, Seyama K, Takahashi K Hochuekkito (TJ-41)
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Journal Title
Evidence-Based Complementary and Alternative Medicine
Volume: 2012
Pages: 976926-976926
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[Journal Article] Osteopontin mediates multidrug resistance of human mesothelioma cells through regulation of CD442010
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Tajima K, Ohashi R, Sekido Y, Hida T, Nar a T, Hashimoto M, Iwakami S, Minakata K, Yae T, Takahashi F, Saya H, and Takahashi K.
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Journal Title
binding to hyaluronate Oncogene
Volume: 29(13)
Pages: 1941-51
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