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Novel treatment for triple negative breast cancer using Poloxamer

Research Project

Project/Area Number 23591912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKurume University

Principal Investigator

IWAKUMA Nobutaka  久留米大学, 医学部, 助教 (30309801)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords癌ナノテクノロジー / トリプルネガティブ乳癌 / ミセルナノ粒子 / 乳癌
Outline of Final Research Achievements

Poloxamer was toxic to triple negative human breast cancer cells MDA-MB-231 in culture as evidenced by propidium iodide assays compared with human mammary epithelial (non-cancer) cells MCF12A. Poloxamer had significant cytotoxicity against MDA-MB-231 than MCF12A by the LDH assay. Poloxamer was not associated with cell proliferation in both MDA-MB-231 and MCF12A.
oPloxamer inhibited the growth of breast cancer tumors in intravenous administration. However, Ploxamer did not inhibit the growth of breast cancer tumors in the oral administration.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] HER2-targeted Therapeutic Strategies for HER2-positive Metastatic Breast Cancers2014

    • Author(s)
      Teruhiko Fujii, Keisuke Miwa, Tomoyuki Ushijima, Mototsugu Matsunaga, Masaru Fukahori, Kotaro Yuge, Uhi Toh, Nobutaka Iwakuma, Ryuji Takahashi, Hiroki Takahashi, Miki Takenaka, Mai Mishima, Yoshito Akagi, Masayoshi Kage , Shino Nakagawa
    • Journal Title

      Current Cancer Therapy Reviews

      Volume: 10 Issue: 3 Pages: 225-233

    • DOI

      10.2174/157339471003150212111019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 乳がん診療へのがんナノテクノロジー研究の応用2013

    • Author(s)
      岩熊伸高、唐 宇飛、高良慶子、三島麻衣、竹中美貴、高橋龍司、白水和雄、S.R.Grobmyer
    • Journal Title

      臨牀と研究

      Volume: 90巻81 Pages: 81-85

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis2013

    • Author(s)
      Miki Takenaka, Naoko Seki, Uhi Toh, Satoshi Hattori, Akihiko Kawahara, Tomohiko Yamaguchi, Keiko Koura, Ryuji Takahashi, Hiroko Otsuka, Hiroki Takahashi, Nobutaka Iwakuma, Shino Nakagawa, Teruhiko Fujii, Tetsuro Sasada, Rin Yamaguchi, Hirohisa Yano, Kazuo Shirouzu, Masayoshi Kage
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 1 Issue: 4 Pages: 625-632

    • DOI

      10.3892/mco.2013.107

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 乳がん診療へのがんナノテクノロジー研究の応用2013

    • Author(s)
      岩熊 伸高、唐 宇飛、高良 慶子、三島 麻衣、竹中 美貴、高橋 龍司、白水 和雄、Stephen R Grobmyer
    • Journal Title

      臨牀と研究

      Volume: 90 Pages: 81-85

    • Related Report
      2012 Research-status Report
  • [Journal Article] 機能的イメージングを応用した治療の個別化-ナノテクノロジーによる乳がんの診断と治療2012

    • Author(s)
      岩熊伸高、Stephen R Grobmyer、唐 宇飛、高良慶子、白水和雄
    • Journal Title

      腫瘍内科

      Volume: 10 Pages: 131-135

    • Related Report
      2012 Research-status Report
  • [Presentation] ナノ粒子を用いた乳がん腫瘍組織へのドラッグデリバリー量的解析2014

    • Author(s)
      岩熊伸高、唐 宇飛、Grobmyer Stephen、三島麻衣、竹中美貴、古川実奈、岩本周子、藤井輝彦、赤木由人、白水和雄、淡河恵津世
    • Organizer
      第22回日本乳癌学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-10 – 2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリヒドロキシフラーレンを用いた非侵襲的イメージングと新しい乳癌局所治療に関する研究2014

    • Author(s)
      岩熊伸高、唐 宇飛、Grobmyer Stephen、Krishna Vijay、三島麻衣、竹中美貴、高橋龍司、高良慶子、藤井輝彦、白水和雄
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] STUDY OF PATIENTS WITH STAGE III BREAST CANCER WHO RECEIVED NEOADJUVANT CHEMOTHERAPY2013

    • Author(s)
      N.Iwakuma,U.Toh,R.Takahashi.M.Mishima,M.Takenaka,K.Koura,T.Fujii,K.Shirouzu
    • Organizer
      PRIMARY THERAPY OF EARLY BREAST CANCER 13TH INTERNATIONAL CONFERENCE
    • Place of Presentation
      ザンクトガレン、スイス
    • Related Report
      2013 Research-status Report
  • [Presentation] 転移性乳癌に対するナノ粒子デリバリー2013

    • Author(s)
      岩熊伸高、唐 宇飛、三島麻衣、竹中美貴、高橋龍司、高良慶子、Grobmyer Stephan、藤井輝彦、白水和雄
    • Organizer
      第21回日本乳癌学会学術集会
    • Place of Presentation
      浜松
    • Related Report
      2013 Research-status Report
  • [Presentation] Targeting nanoparticle: A new material in breast oncology2012

    • Author(s)
      N. Iwakuma, S. R. Grobmyer, U. Toh, K. Koura, H. Otsuka, R. Takahashi, M. Takenaka, K. Shirouzu
    • Organizer
      第20回日本乳癌学会学術総会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] Active targeting nanoparticle for breast cancer diagnosis and treatment2012

    • Author(s)
      N. Iwakuma, S. R. Grobmyer, U. Toh, K. Koura, M. Mishima, M. Takenaka, H. Otsuka, R. Takahashi, K. Shirouzu
    • Organizer
      2012 Breast Cancer Symposium
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 乳癌克服のための癌ナノテクノロジー研究の役割と今後の展望2011

    • Author(s)
      岩熊伸高
    • Organizer
      第19回日本乳癌学会学術総会
    • Place of Presentation
      仙台国際センター(宮城)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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