Establishment of the animal model of lymphangioma using human lymphangioma derived lymphatic endothelial cell
| Project/Area Number |
23591917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Keio University (2012-2014)
National Research Institute for Child Health and Development (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 部長 (70213486)
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| Co-Investigator(Renkei-kenkyūsha) |
HATA Jyunichi 独立行政法人国立成育医療研究センター, 名誉総長 (90051614)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | リンパ管腫 / リンパ管奇形 / モデル動物 / リンパ管内皮細胞 / 細胞生物学 / 病態発生 / 新規治療法 / トランスレーショナルリサーチ / 病理学 / 蛍光 / 発光 / リンパ管腫由来内皮細胞 / モデル動物作成 |
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| Outline of Final Research Achievements |
The purposes of this study were the elucidation of the mechanism for the pathogenesis of lymphangioma, the exploration of seeds for new therapeutic methods for the disease, and establishment of animal model of the lymphangioma necessary to examine the new therapeutic methods.
In this study, we established technique to make lymphangioma-like lesion in the NOG mouse by transplanting primary culture cells derived from lymphangioma lesions. In addition, we succeeded in immortalizing this cell, and introducing the fluorescence and light emission protein. We need to continue this project it in order to make an animal model in which the lesion is observable from the outside the body by transplanting this cell.
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Report
(5 results)
Research Products
(44 results)
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[Journal Article] Propranolol as an Alternative Treatment Option for Pediatric Lymphatic Malformation2013
Author(s)
Ozeki M, Kanda K,Kawamoto N,Ohnishi H,Fujino A,Hirayama M,Kato Z,Azuma E,Fukao T,Kondo N.
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 229
Issue: 1
Pages: 61-66
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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[Presentation] 顔面リンパ管腫の手術経験2014
Author(s)
彦坂信, 金子剛, 長島隼人, 藤野明浩
Organizer
第57回日本形成外科学会総会・学術集会
Place of Presentation
長崎
Year and Date
2014-04-09 – 2014-04-11
Related Report
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[Presentation] Direct Effects of each drugs (especially OK-432) for Human Lymphangioma Derived Lymphatic Endothelial Cell2013
Author(s)
Masataka Takahashi, Akihiro Fujino, Masaya Suzuhigashi, Hideaki Tanaka, Toshihiko Watanabe, Kaori Satou, Michinobu Ohno, Waka Yamada, Kouji Yamada, Yasushi Fuchimoto, Yutaka Kanamori, Akihiro Umezawa
Organizer
46th Annmual Meeting of Pacific Association of Pediatric Surgeons
Place of Presentation
Sydney
Related Report
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[Presentation] 当院における乳麋胸水に対する治療2013
Author(s)
和田友香, 藤野明浩, 兼重昌夫, 花井彩江, 高橋重裕, 藤永英志, 塚本桂子, 渕本康史, 金森豊, 中村知夫, 伊藤裕司
Organizer
第49回日本周産期・新生児医学会学術集会
Place of Presentation
横浜
Related Report
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[Presentation] Propranolol for intractable lymphatic malformation(lymphangioma):a report of 4 cases.2012
Author(s)
Fujino A,Ozaki M,Kanamori Y,Tanaka H,Watanabe T,Takeda N,Yamada W,Takahashi M,Yamada K,Ishihama H.
Organizer
ISSVA 2012(International Society of Studying Vascular Anomaly,国際血管奇形研究学会）
Place of Presentation
マルメ、スウェーデン
Related Report
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[Presentation] A Study of Lymphatic Flow in Lymphangioma.2012
Author(s)
Fujino A,Kitamura M,Kuroda T,Kitano Y,Morikawa N,Tanaka H,Takayasu H,Takeda N,Suzuhigashi M,Matsuda S,Yamane Y,Masaki H.
Organizer
AAPS 2012(Asian Association of Pediatric Surgeons,アジア小児外科学会）
Place of Presentation
ソウル、韓国
Related Report
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