| Project/Area Number |
23591919
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAYAMA Joji 東京大学, 医学部附属病院, 准教授 (20251308)
YAMASHITA Hiroharu 東京大学, 医学部附属病院, 講師 (50599397)
ISHIGAMI Hironori 東京大学, 医学部附属病院, 講師 (80372382)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOU Taichi 東京大学, 大学院疾患生命工学センター, 准教授 (50447421)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 胃癌腹膜播種 / ドラッグデリバリーシステム / 腹腔内化学療法 / シスプラチン / ヒアルロン酸 / ハイドロゲル / 腹膜播種 |
|---|
| Research Abstract |
In this study, we aimed to produce novel biological material which is suitable for intraperitoneal (i.p.) chemotherapy. Water-soluble cisplatinum was incorporated in in-situ cross-linkage hyaluronic acid (HA) gel to prolong the intraperitoneal retention of cisplatinum. We could show that cisplatinum was released from HA gel continuously for more than 5 days. In vivo assay using mouse peritoneal dissemination model, HA gel with 1 mg/kg cisplatinum decreased the total weight of peritoneal disseminated nodulus, but the i.p. administration of the same amount of cisplatinum did not show anti-tumor effect. In situ cross linkage HA gel is useful for i.p. administration of hydrophilic anti-cancer drugs as a novel drug delivery system.
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