Development of cisplutium binding hialulonic acid gel as a novel intraperitoneal chemotherapeutic agent for peritoneal dissemination of gastric cancer
| Project/Area Number |
23591919
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAYAMA Joji 東京大学, 医学部附属病院, 准教授 (20251308)
YAMASHITA Hiroharu 東京大学, 医学部附属病院, 講師 (50599397)
ISHIGAMI Hironori 東京大学, 医学部附属病院, 講師 (80372382)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOU Taichi 東京大学, 大学院疾患生命工学センター, 准教授 (50447421)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 胃癌腹膜播種 / ドラッグデリバリーシステム / 腹腔内化学療法 / シスプラチン / ヒアルロン酸 / ハイドロゲル / 腹膜播種 |
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| Research Abstract |
In this study, we aimed to produce novel biological material which is suitable for intraperitoneal (i.p.) chemotherapy. Water-soluble cisplatinum was incorporated in in-situ cross-linkage hyaluronic acid (HA) gel to prolong the intraperitoneal retention of cisplatinum. We could show that cisplatinum was released from HA gel continuously for more than 5 days. In vivo assay using mouse peritoneal dissemination model, HA gel with 1 mg/kg cisplatinum decreased the total weight of peritoneal disseminated nodulus, but the i.p. administration of the same amount of cisplatinum did not show anti-tumor effect. In situ cross linkage HA gel is useful for i.p. administration of hydrophilic anti-cancer drugs as a novel drug delivery system.
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Report
(4 results)
Research Products
(118 results)
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[Presentation] 腹膜播種を伴う胃癌に対する腹腔内投与併用化学療法の有用性を検証する第III相試験(PHOENIX-GC試験)2013
Author(s)
高張大亮,石神浩徳,福島亮治,梨本篤,藪崎裕,小寺泰弘,伊藤誠二,今本治彦,今野元博,藤原義之,田中淳二,上之園芳一,山口拓洋,山口博紀,北山丈二
Organizer
日本消化器病学会雑誌
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[Presentation] 大腸癌腹膜播種再発における腹腔洗浄液中CEA-mRNA定量の意義2013
Author(s)
室野浩司,風間伸介,田中敏明,田中潤一郎,清松知充,川合一茂,野澤宏彰,金沢孝満,山口博紀,石原聡一郎,須並英二,北山丈二,渡邉聡明
Organizer
日本大腸肛門病学会雑誌
Related Report
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[Presentation] 大腸癌腹膜播種症例の治療成績2013
Author(s)
須並英二,室野浩司,野澤宏彰,風間伸介,金沢孝満,川合一茂,清松知充,田中潤一郎,田中敏明,米山さとみ,山口博紀,石原聡一郎,北山丈二,渡邉聡明
Organizer
日本臨床外科学会雑誌
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[Presentation] 虫垂癌腹膜播種に対して腹腔内化学療法を施行した1例2012
Author(s)
石井博章,谷澤健太郎,金沢孝満,斎藤晋祐,風間伸介,川合一茂,清松知充,田中潤一郎,田中敏明,須並英二,北山丈二,渡邉聡明
Organizer
日本大腸肛門病学会雑誌
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