Effect of synthesis ghrelin administration for the management of inflammation after esophagectomy
| Project/Area Number |
23591929
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
TAKIGUCHI Shuji 大阪大学, 医学(系)研究科(研究院), 講師 (00301268)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Hiroshi 大阪大学, 医学部付属病院消化器外科, 助教 (80362713)
YAMASAKI Makoto 大阪大学, 医学部付属病院消化器外科, 助教 (50444518)
MIYAZAKI Yasuhiro 大阪大学, 医学部付属病院消化器外科, 助教 (00571390)
日浦 祐一郎 大阪大学, 医学部附属病院, その他 (60571354)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 食道癌 / グレリン / SIRS / 食道がん |
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| Research Abstract |
Ghrelin is reported to have anti-inflammatory effects by inhibiting the expression of inflammatory cytokines. We performed randomized, placebo-controlled phase II study to investigate the clinical efficacy and feasibility of administering ghrelin in the patients undergoing esophagectomy. A total of 40 patients with primary esophageal cancer were assigned into either a ghrelin (n=20) or placebo (n=20) group. There were no significant differences in the background characteristics in both groups. Patients treated with ghrelin showed shorter SIRS durations than controls and they showed lower C-reactive protein and interleukin-6 concentrations than controls. Ghrelin administration was not associated with any adverse events. In conclusion, the present study showed that ghrelin administration in the early postoperative phase was safe and able to improve inflammation after esophagectomy.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Clinical significance of Ghrelin Expression in the Gastric Mucosa of Morbidly Obese Patients2013
Author(s)
Miyazaki Y, Takiguchi S, Seki Y, Kasama K, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Mori M, Doki Y.
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Journal Title
Related Report
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[Journal Article] Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients : A prospective, randomized, placebo-controlled phase 2 study2012
Author(s)
Hiura Y, Takiguchi S, Yamamoto K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Miyata H, Fujiwara Y, Mori M, Kangawa K, Doki Y.
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Journal Title
Cancer
Volume: 118
Pages: 4785-4794
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