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The exploration of novel therapeutic target in gastric cancer by comprehensive tyrosine-kinase analysis

Research Project

Project/Area Number 23591930
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOsaka University

Principal Investigator

YAMASAKI Makoto  大阪大学, 医学(系)研究科(研究院), 助教 (50444518)

Co-Investigator(Kenkyū-buntansha) TAKIGUCHI Shuuji  大阪大学, 医学部付属病院消化器外科, 講師 (00301268)
MIYATA Hiroshi  大阪大学, 医学部付属病院消化器外科, 講師 (80362713)
KUROKAWA Yukinori  大阪大学, 医学部付属病院消化器外科, 助教 (10470197)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords胃癌 / チロシンキナーゼ / 腹膜播種 / 網羅的発現解析 / 化学療法感受性
Research Abstract

We analyzed the comprehensive gene expression in gastric cancer to explore the novel tyrosine-kinase related to the development of cancer, especially peritoneal dissemination. Then the novel and well-known tyrosine-kinases; KSR1 and MEK, Her2 and FGFR1 were identified. KSR1 is a tyrosine-kinase that functions as positive regulator of Ras pathway, and associated with the cell motility, invasion and peritoneal dissemination. FOXM1, DOK2 and REGIV are identified as the downstream molecules of the tyrosine-kinases, MEK, Her2 and FGFR1, respectively in consequence of the analysis of the correlativity between the pathways of these tyrosine-kinases and gene expression analysis. It was shown that these molecules related with the prognosis, peritoneal dissemination and the sensitivity of anticancer drug.
This result may enable us to elucidate the signaling related to the biological character of gastric cancer and develop the novel molecular-targeted agent.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Overexpression of forkhead box M1 transcription factor (FOXM1) is a potential prognostic marker and enhances chemoresistance for docetaxel in gastric cancer2013

    • Author(s)
      Okada K, Fujiwara Y, Takahashi T, Nakamura Y, Takiguchi S, Nakajima K, Miyata H, Yamasaki M, Kurokawa Y, Mori M, Doki Y.
    • Journal Title

      Ann Surg Oncol

      Volume: 20(3) Pages: 1035-43

    • Related Report
      2013 Final Research Report
  • [Journal Article] Overexpression of forkhead box M1 transcription factor (FOXM1) is a potential prognostic marker and enhances chemoresistance for docetaxel in gastric cancer2013

    • Author(s)
      Okada Kaoru, Fujiwara Yosiyuki, Takahashi Tsuyoshi, Nakamura Yusuke, Takiguti Syuji, Nakajima Kiyokazu, Miyata Hiroshi, Yamasaki Makoto, Kurokawa Yukinori, Mori Masaki,and Doki Yuichiro
    • Journal Title

      Annals of Surgical Oncology

      Volume: 20 Issue: 3 Pages: 1035-1043

    • DOI

      10.1245/s10434-012-2680-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] DOK2 as a marker of poor prognosis of patients with gastric adenocarcinoma after curative resection2012

    • Author(s)
      Miyagaki H, Yamasaki M, Takahashi T, Kurokawa Y, Miyata H, Nakajima K, Takiguchi S, Fujiwara Y, Mori M, Doki Y.
    • Journal Title

      Ann Surg Oncol

      Volume: 19(5) Pages: 1560-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] REGIV as a potential biomarker for peritoneal dissemination in gastric adenocarcinoma2012

    • Author(s)
      Moon JH, Fujiwara Y, Nakamura Y, Okada K, Hanada H, Sakakura C, Takiguchi S, Nakajima K, Miyata H, Yamasaki M, Kurokawa Y, Mori M, Doki Y.
    • Journal Title

      J Surg Oncol

      Volume: 105(2) Pages: 189-94

    • Related Report
      2013 Final Research Report
  • [Journal Article] DOK2 as a marker of poor prognosis of patients with gastric adenocarcinoma after curative resection2011

    • Author(s)
      Hiromichi Miyagaki, Makoto Yamasaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Hiroshi Miyata, Kiyokazu Nakajima, Shuji Takiguchi, Yoshiyuki Fujiwara, Masaki Mori, Yuichiro Doki
    • Journal Title

      Annals of Surgical Oncology

      Volume: Epub ahead of print

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 胃癌におけるFoxM1の発現と薬剤耐性についての検討2012

    • Author(s)
      岡田かおる
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-12
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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