Fluorescence-guided detection and genetic analysis of circulating tumor cells
| Project/Area Number |
23591932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Toshiyoshi 岡山大学, 大学院医歯薬学研究科, 教授 (00304303)
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| Co-Investigator(Renkei-kenkyūsha) |
TAZAWA Hiroshi 岡山大学, 病院, 助教 (90415513)
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| Research Collaborator |
SHIGEYASU Kunitoshi 岡山大学, 大学院医歯薬学研究科, 大学院生
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 末梢血循環腫瘍細胞 / アデノウイルス / 遺伝子解析 / 消化器癌 / 大腸癌 / 蛍光 / 循環腫瘍細胞 |
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| Research Abstract |
In addition to the conventional clinical information, molecular information obtained from cancer tissue is being used for proper selection of cancer therapy. The circulating tumor cells in the blood of cancer patients, if available, might be valuable source for such molecular information. We tried and succeeded to capture and analyze the rare tumor cells in the blood using a virus that can detect cancer cells with a fluorescent dye. This technology must be a novel molecular diagnostic method for cancer.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells into S/G2/M-phases.2013
Author(s)
Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T
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Journal Title
Clin Cancer Res
Volume: 19
Issue: 23
Pages: 6495-6505
DOI
Related Report
Peer Reviewed
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[Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases.2013
Author(s)
Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T.
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Journal Title
Clinical Cancer Research
Volume: 19
Pages: 6495-6505
NAID
Related Report
Peer Reviewed
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[Journal Article] A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression.2012
Author(s)
Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T.
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Journal Title
European journal of cancer
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Ileal perforation induced by acute radiation injury under gefitinib treatment.2011
Author(s)
Muraoka T, Tsukuda K, Toyooka S, Kagawa S, Naomoto Y, Takemoto M, Katsui K, Kanazawa S, Maki Y, Masuda H, Harada M, Asano H, Naito M, Miyoshi S.
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Journal Title
International journal of clinical oncology
Volume: 16
Issue: 6
Pages: 774-777
DOI
Related Report
Peer Reviewed
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