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Fluorescence-guided detection and genetic analysis of circulating tumor cells

Research Project

Project/Area Number 23591932
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOkayama University

Principal Investigator

KAGAWA Shunsuke  岡山大学, 大学病院, 講師 (00362971)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Toshiyoshi  岡山大学, 大学院医歯薬学研究科, 教授 (00304303)
Co-Investigator(Renkei-kenkyūsha) TAZAWA Hiroshi  岡山大学, 病院, 助教 (90415513)
Research Collaborator SHIGEYASU Kunitoshi  岡山大学, 大学院医歯薬学研究科, 大学院生
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords末梢血循環腫瘍細胞 / アデノウイルス / 遺伝子解析 / 消化器癌 / 大腸癌 / 蛍光 / 循環腫瘍細胞
Research Abstract

In addition to the conventional clinical information, molecular information obtained from cancer tissue is being used for proper selection of cancer therapy. The circulating tumor cells in the blood of cancer patients, if available, might be valuable source for such molecular information. We tried and succeeded to capture and analyze the rare tumor cells in the blood using a virus that can detect cancer cells with a fluorescent dye. This technology must be a novel molecular diagnostic method for cancer.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 2011

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (11 results)

  • [Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells into S/G2/M-phases.2013

    • Author(s)
      Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T
    • Journal Title

      Clin Cancer Res

      Volume: 19 Issue: 23 Pages: 6495-6505

    • DOI

      10.1158/1078-0432.ccr-13-0742

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advances in adenovirus-mediated p53 cancer gene therapy.2013

    • Author(s)
      Tazawa H, Kagawa S, Fujiwara T
    • Journal Title

      Expert opinion on biological therapy.

      Volume: 13 Issue: 11 Pages: 1569-1583

    • DOI

      10.1517/14712598.2013.845662

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel synergistic effect of iron depletion on antiangiogenic cancer therapy.2013

    • Author(s)
      Ohara T, Noma K, Urano S, Watanabe S, Nishitani S, Tomono Y, Kimura F, Kagawa S, Shirakawa Y, Fujiwara T
    • Journal Title

      International Journal of Cancer

      Volume: 132 Issue: 11 Pages: 2705-2713

    • DOI

      10.1002/ijc.27943

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases.2013

    • Author(s)
      Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T.
    • Journal Title

      Clinical Cancer Research

      Volume: 19 Pages: 6495-6505

    • NAID

      120005468273

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus2012

    • Author(s)
      Sasaki, T.
    • Journal Title

      Gene Therapy

      Volume: (Epub ahead of print) Issue: 1 Pages: 112-118

    • DOI

      10.1038/gt.2011.213

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression.2012

    • Author(s)
      Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T.
    • Journal Title

      European journal of cancer

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells.2012

    • Author(s)
      Yoshida, R.
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 61 Issue: 11 Pages: 1905-1916

    • DOI

      10.1007/s00262-012-1249-x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 放射線療法とPaclitaxel化学療法にて長期CRが得られた胃癌直腸膀胱窩再発の1例2011

    • Author(s)
      金谷信彦, 香川俊輔, 宇野太, 國富彩, 小川誠之, 藤原俊義
    • Journal Title

      癌と化学療法

      Volume: 38 Pages: 2100-2102

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腹腔鏡補助下噴門側胃切除術 観音開き法食道残胃吻合2011

    • Author(s)
      西崎正彦, 香川俊輔, 宇野太, 岸本浩行, 白川靖博, 藤原俊義
    • Journal Title

      消化器外科

      Volume: 34 Pages: 1687-1697

    • Related Report
      2011 Research-status Report
  • [Journal Article] 最新の外科治療総論 アプローチを中心に センチネルリンパ節ナビゲーション手術 胃がん(Q&A/特集)2011

    • Author(s)
      西崎正彦, 香川俊輔, 藤原俊義
    • Journal Title

      がん治療レクチャー

      Volume: 2 Pages: 788-792

    • Related Report
      2011 Research-status Report
  • [Journal Article] Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas2011

    • Author(s)
      Sasaki T, et al
    • Journal Title

      Clinical Cancer Research

      Volume: 17 Issue: 7 Pages: 1828-1838

    • DOI

      10.1158/1078-0432.ccr-10-2066

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Telomerase-specific oncolytic virotherapy Tor human gastrointestinal cancer2011

    • Author(s)
      Fujiwara T, et al
    • Journal Title

      Expert Review of Anticancer Therapy

      Volume: 11 Issue: 4 Pages: 525-532

    • DOI

      10.1586/era.10.200

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ileal perforation induced by acute radiation injury under gefitinib treatment.2011

    • Author(s)
      Muraoka T, Tsukuda K, Toyooka S, Kagawa S, Naomoto Y, Takemoto M, Katsui K, Kanazawa S, Maki Y, Masuda H, Harada M, Asano H, Naito M, Miyoshi S.
    • Journal Title

      International journal of clinical oncology

      Volume: 16 Issue: 6 Pages: 774-777

    • DOI

      10.1007/s10147-011-0249-8

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic Interaction of Telomerase-Specific Oncolytic Virotherapy and Chemotherapeutic Agents for Human Cancer.2011

    • Author(s)
      Fujiwara T, Kagawa S, Tazawa H.
    • Journal Title

      Current pharmaceutical biotechnology

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 蛍光標識による血中遊離癌細胞のLiquid Biopsy技術のバイオマーカー解析への応用2013

    • Author(s)
      重安邦俊,橋本悠里,竹原清人,宇野太,永坂岳司,田澤大,香川俊輔,浦田泰生,藤原俊義
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2013-10-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] テロメラーゼ活性を指標とする血中遊離癌細胞の高感度検出法の開発と遺伝子解析技術への応用2013

    • Author(s)
      重安邦俊,橋本悠里,宇野太,永坂岳司,田澤大,香川俊輔,水口裕之,浦田泰生,藤原俊義
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-04-13
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 腫瘍特異的制限増殖型アデノウイルスを用いた血液循環腫瘍細胞の遺伝子解析技術の開発2012

    • Author(s)
      重安邦俊、香川俊輔、藤原俊義、他
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] New method for investigating genetic mutations of circulating tumor cells using a telomerase-specific replication-competent adenovirus2012

    • Author(s)
      重安邦俊、香川俊輔、藤原俊義、他
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] A highly sensitive detection system of genetic alterations in circulating tumor cells using a telomerase-specific replication-competent adenovirus2012

    • Author(s)
      Shigeyasu K, Kagawa S, Fujiwara T, 他
    • Organizer
      AACR annual meeting 2012
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Final Research Report
  • [Presentation] A highly sensitive detection system of genetic alterations in circulating tumor cells using a telomerase-specific replication-competent adenovirus2012

    • Author(s)
      Kunitoshi Shigeyasu
    • Organizer
      AACR annual meeting 2012
    • Place of Presentation
      米国 シカゴ
    • Related Report
      2012 Research-status Report
  • [Presentation] 胃癌幹細胞に対するテロメラーゼ特異的腫瘍融解ウイルス治療2011

    • Author(s)
      香川俊輔,藤原俊義、他
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 消化器癌診断治療におけるサイトメトリーの役割胃癌幹細胞に対するテロメラーゼ特異的腫瘍融解ウイルス治療とその作用機序の解析2011

    • Author(s)
      香川俊輔,藤原俊義、他
    • Organizer
      第21回日本サイトメトリー学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2011-06-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 胃癌幹細胞に対するテロメラーゼ特異的腫瘍融解ウイルス治療2011

    • Author(s)
      香川俊輔, 矢野修也, 田澤大, 橋本悠里, 宇野太, 岸本浩行, 西崎正彦, 浦田泰生, 藤原俊義
    • Organizer
      第49回 日本癌治療学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 同時多発性胃癌術後の残胃癌に関する検討2011

    • Author(s)
      香川俊輔, 宇野太, 岸本浩行, 西崎正彦, 白川靖博, 永坂岳司, 野間和広, 近藤喜太, 田辺俊介, 藤原俊義
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 消化器癌診断治療におけるサイトメトリーの役割 胃癌幹細胞に対するテロメラーゼ特異的腫瘍融解ウイルス治療とその作用機序の解析2011

    • Author(s)
      香川俊輔, 矢野修也, 藤原俊義
    • Organizer
      第21回日本サイトメトリー学会学術集会
    • Place of Presentation
      京都市国際交流会館(京都府)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2023-03-16  

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