Fluorescence-guided detection and genetic analysis of circulating tumor cells
Project/Area Number |
23591932
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Toshiyoshi 岡山大学, 大学院医歯薬学研究科, 教授 (00304303)
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Co-Investigator(Renkei-kenkyūsha) |
TAZAWA Hiroshi 岡山大学, 病院, 助教 (90415513)
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Research Collaborator |
SHIGEYASU Kunitoshi 岡山大学, 大学院医歯薬学研究科, 大学院生
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 末梢血循環腫瘍細胞 / アデノウイルス / 遺伝子解析 / 消化器癌 / 大腸癌 / 蛍光 / 循環腫瘍細胞 |
Research Abstract |
In addition to the conventional clinical information, molecular information obtained from cancer tissue is being used for proper selection of cancer therapy. The circulating tumor cells in the blood of cancer patients, if available, might be valuable source for such molecular information. We tried and succeeded to capture and analyze the rare tumor cells in the blood using a virus that can detect cancer cells with a fluorescent dye. This technology must be a novel molecular diagnostic method for cancer.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases2013
Author(s)
Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T.
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Journal Title
Clinical Cancer Research
Volume: Vol. 19
Pages: 6495-6505
DOI
Related Report
Peer Reviewed
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[Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases.2013
Author(s)
Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T.
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Journal Title
Clinical Cancer Research
Volume: 19
Pages: 6495-6505
DOI
Related Report
Peer Reviewed
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[Journal Article] A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus.2012
Author(s)
Sasaki T, Tazawa H, Hasei J, Osaki S, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Kagawa S, Uno F, Urata Y, Ozaki T, Fujiwara T.
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Journal Title
Gene Therapy
Volume: -
Pages: -
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression.2012
Author(s)
Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T.
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Journal Title
European journal of cancer
Volume: -
Pages: -
DOI
Related Report
Peer Reviewed
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[Journal Article] Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells.2012
Author(s)
Yoshida R, Tazawa H, Hashimoto Y, Yano S, Onishi T, Sasaki T, Shirakawa Y, Kishimoto H, Uno F, Nishizaki M, Kagawa S, Fujiwara T.
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Journal Title
Cancer immunology, immunotherapy
Volume: -
Pages: -
DOI
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Peer Reviewed
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[Journal Article] Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas.2011
Author(s)
Sasaki T, Tazawa H, Hasei J, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Uno F, Kagawa S, Morimoto Y, Urata Y, Ozaki T, Fujiwara T.
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Journal Title
Clinical cancer research
Volume: 17
Pages: 1828-1838
DOI
Related Report
Peer Reviewed
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[Journal Article] Ileal perforation induced by acute radiation injury under gefitinib treatment.2011
Author(s)
Muraoka T, Tsukuda K, Toyooka S, Kagawa S, Naomoto Y, Takemoto M, Katsui K, Kanazawa S, Maki Y, Masuda H, Harada M, Asano H, Naito M, Miyoshi S.
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Journal Title
International journal of clinical oncology
Volume: 16
Pages: 774-777
DOI
Related Report
Peer Reviewed
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[Presentation] 同時多発性胃癌術後の残胃癌に関する検討2011
Author(s)
香川俊輔, 宇野太, 岸本浩行, 西崎正彦, 白川靖博, 永坂岳司, 野間和広, 近藤喜太, 田辺俊介, 藤原俊義
Organizer
第66回日本消化器外科学会総会
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2011年7月13日
Related Report
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