| Project/Area Number |
23591935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YASUTOMO Koji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (30333511)
NISHIOKA Masanori 徳島大学, 病院, 助教 (50398020)
IKEMOTO Tetsuya 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20398019)
TAKASU Chie 徳島大学, 大学院ヘルスバイオサイエンス研究部, 特任助教 (70582823)
NISHI Masaaki 徳島大学, 病院, 医員 (70464344)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 直腸癌 / 術前放射線治療 / 調節性T細胞 / Foxp3 / Notchシグナル / Delta / Jagged / CD47 / THBS-1 / 調節性T細胞 Treg |
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| Research Abstract |
(Aim)To clarify the mechanisim of distant metastasis after radiotherapy for rectal cancer.(Methods)We used Balb/c nude mice. We cut anterior wall of rectum, and implanted HT-29 cells into posterior wall. Seven days after, we compared the several immune factors between radiation therapy group and non-therapy group using RT-PCR and flow cytometric analysis.(Result)In radiotherapy group, Foxp3, Notch1, Jagged1 mRNA ratio in tumor were not significantly increased compared with non-therapy group. Foxp3 ratio in spleen tended to be higher in radiotherapy group, compared with control and non-therapy group.(Conculusion)In radiotherapy for rectal cancer, immune tolerance by Foxp3 up-regulation in blood may increase distant metastasis. Foxp3 may be a important factor to regulate distant metastasis in rectal cancer patients with radiotherapy or chemoradiotherapy.
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