Gene expression analysis on chromosome 17q25.1 in esophageal squamous cell carcinoma
Project/Area Number |
23591937
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Iwate Medical University (2012-2013) Kyushu University (2011) |
Principal Investigator |
IWAYA Takeshi 岩手医科大学, 医学部, 講師 (70405801)
|
Co-Investigator(Kenkyū-buntansha) |
TANAKA Fumiaki 九州大学, 大学病院, 講師 (30332836)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 食道癌 / 遺伝子発現 / 遺伝子変異 / 変異 / 癌抑制遺伝子 / がんゲノム解析 / 発現解析 |
Research Abstract |
Tylosis is an autosomal dominant skin disorder that is associated with the early onset of esophageal squamous cell carcinoma (ESCC) in several families.The tylosis esophageal cancer (TOC) gene locus has been mapped to chromosome 17q25.1 using linkage analyses of pedigrees of such families. This region is also frequently lost in sporadic ESCC. Therefore, genes involved in the development of esophageal cancer may exist in the TOC region on 17q25.1. Among many genes in the region, significant downregulation of ST6GALNAC1 expression in esophageal cancer tissues was confirmed. Frequent mutation, loss of heterozygosity, and hypermethylation in ST6GALNAC1 gene were observed. Our results suggest that downregulation of ST6GALNAC1 via hypermethylation and LOH are associated with the development of ESCC.
|
Report
(4 results)
Research Products
(55 results)
-
-
[Journal Article] Up-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancer.2014
Author(s)
Takahashi Y, Iwaya T, Sawada G, Kurashige J, Matsumura T, Uchi R, Ueo H, Takano Y, Eguchi H, Sudo T, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K.
-
Journal Title
Ann Surg Oncol.
Volume: 21 (1)
Issue: 1
Pages: 205-12
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Tumor-derived tenascin-C promotes the epithelial-mesenchymal transition in colorectal cancer cells2013
Author(s)
Takahashi Y, Sawada G, Kurashige J, Matsumura T, Uchi R, Ueo H, Ishibashi M, Takano Y, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K.
-
Journal Title
Anticancer Res.
Volume: 33(5)
Pages: 1927-34
Related Report
Peer Reviewed
-
-
-
[Journal Article] Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma2013
Author(s)
Ishibashi M, Kogo R, Shibata K, Sawada G, Takahashi Y, Kurashige J, Akiyoshi S, Sasaki S, Iwaya T, Sudo T, Sugimachi K, Mimori K, Wakabayashi G.
-
Journal Title
Oncol Rep
Volume: 29(3)
Pages: 946-50
Related Report
Peer Reviewed
-
[Journal Article] Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.2013
Author(s)
Iwaya T, Fukagawa T, Suzuki Y, Takahashi Y, Sawada G, Ishibashi M, Kurashige J, Sudo T, Tanaka F, Shibata K, Endo F, Katagiri H, Ishida K, Kume K, Nishizuka S, Iinuma H, Wakabayashi G, Mori M, Sasako M, Mimori K.
-
Journal Title
Clin Cancer Res
Volume: 19 (23)
Issue: 23
Pages: 6438-49
DOI
Related Report
Peer Reviewed
-
[Journal Article] Tumor-derived tenascin-C promotes the epithelial-mesenchymal transition in colorectal cancer cells.2013
Author(s)
Takahashi Y, Sawada G, Kurashige J, Matsumura T, Uchi R, Ueo H, Ishibashi M, Takano Y, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K.
-
Journal Title
Anticancer Res.
Volume: 33 (5)
Pages: 1927-34
Related Report
Peer Reviewed
-
[Journal Article] Clinical significance of PICT1 in patients of hepatocellular carcinoma with wild-type TP53.2013
Author(s)
Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K.
-
Journal Title
Ann Surg Oncol.
Volume: Supple 3:
Issue: S3
Pages: 537-544
DOI
Related Report
Peer Reviewed
-
[Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis.2013
Author(s)
Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M.
-
Journal Title
Cancer Res
Volume: 1; 73(7)
Issue: 7
Pages: 2059-69
DOI
Related Report
Peer Reviewed
-
[Journal Article] Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma.2013
Author(s)
Ishibashi M, Kogo R, Shibata K, Sawada G, Takahashi Y, Kurashige J, Akiyoshi S, Sasaki S, Iwaya T, Sudo T, Sugimachi K, Mimori K, Wakabayashi G, Mori M.
-
Journal Title
Oncol Rep
Volume: 29(3)
Issue: 3
Pages: 946-50
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers.2012
Author(s)
Ishida K, Nishiduka S, Chiba T, Ikeda M, Kume K, Endo F, Katagiri H, Matsuo T, Noda H, Iwaya T, Yamada N, Fujiwara H, Takahashi M, Itabashi T, Uesugi N,Maesawa C, Tamura G, Sugai T, Otsuka K, Koeda K, Wakabayashi G.
-
Journal Title
PLoS One
Volume: 7(8)
Issue: 8
Pages: e43236-e43236
DOI
Related Report
Peer Reviewed
-
[Journal Article] Expression of Mesenchymal Markers Vimentin and Fibronectin: The Clinical Significance in Esophageal Squamous Cell Carcinoma.2012
Author(s)
Sudo T, Iwaya T, Nishida N, Sawada G, Takahashi Y, Ishibashi M, Shibata K, Fujita H, Shirouzu K, Mori M, Mimori K.
-
Journal Title
Ann Surg Oncol
Volume: Epub
Issue: S3
Pages: 324-335
DOI
Related Report
Peer Reviewed
-
[Journal Article] Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma2012
Author(s)
Mar ; 113(2): 204-9. 2. Yokobori T, Mimori K, Iwatsuki M, Ishii H, Tanaka F, Sato T, Toh H, Sudo T, Iwaya T, Tanaka Y, Onoyama I, Kuwano H, Nakayama KI, Mori M.
-
Journal Title
Int J Oncol
Volume: 41(1)
Pages: 253-9
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers2011
Author(s)
Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M
-
Journal Title
Cancer Res
Volume: 71
Issue: 20
Pages: 6320-6
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab2011
Author(s)
Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.]
-
Journal Title
Clin Cancer Res
Volume: 17(9)
Issue: 9
Pages: 2725-33
DOI
Related Report
Peer Reviewed
-
[Presentation] MicroRNA 760 regulates gastric cancer progression by downregulation of histone mRNA expression2014
Author(s)
Takeshi Iwaya, Takeo Fukagawa, Yutaka Suzuki, Tomoya Sudo, Kaoru Ishida, Kohei Kume, Satoshi Nishizuka, Hisae Iinuma, Masaki Mori, Mitsuru Sasako, Go Wakabayashi, Koshi Mimori
Organizer
アメリカ癌学会
Place of Presentation
サンディエゴ
Related Report
-
-
-
-
-
-
[Presentation] Gene expression analysis of bone marrow cells in gastric cancer patients2013
Author(s)
Takeshi Iwaya, Takeo Fukagawa, Yutaka Suzuki, Yusuke Takahashi, Genta Sawada, Kohei Kume, Satoshi Nishizuka, Hisae Iinuma, Go Wakabayashi, Mitsuru Sasako, Masaki Mori, Koshi Mimori
Organizer
日本癌学会
Place of Presentation
横浜
Related Report
-
-
-
-
-
[Presentation] 胃癌骨髄・原発巣におけるHistone mRNAおよびmiR-760発現変化2012
Author(s)
岩谷岳, 三森功士, 西田尚弘, 古後龍之介, 赤木智徳, 高橋佑典, 澤田元太, 石橋正久, 柴田浩平, 田中文明, 主藤智也, 若林剛, 深川剛生, 笹子三津留, 森正樹.
Organizer
第112回日本外科学会
Place of Presentation
幕張
Related Report
-
[Presentation] 胃癌におけるHER2/neuを制御するマイクロRNAの臨床病理学的意義2012
Author(s)
西田尚弘, 三森功士, 石橋正久, 高橋祐典, 澤田元太, 岩谷岳, 主藤朝也, 田中文明, 柴田浩平, 石井秀始, 森正樹.
Organizer
第112回日本外科学会
Place of Presentation
幕張
Related Report
-
[Presentation] 大腸癌におけるmicroRNA 144によるmTOR signaling pathwayの制御.2012
Author(s)
石丸神矢, 岩谷岳, 高橋佑典, 石橋正久, 澤田元太, 古後龍之介, 西田尚弘, 主藤朝也, 田中文明, 柴田浩平, 三森功士, 森正樹.
Organizer
第112回日本外科学会
Place of Presentation
幕張
Related Report
-
-
-
-
-
-
-
[Presentation] Histone mRNAs and miRNA-760 expression predict gastric cancer patient prognosis2011
Author(s)
T Iwaya, K Mimori, N Nishida, R Kogo, K Shibata, F Tanaka, T Sudo, T Akagi, G Sawada, Y Takahashi, M Ishibashi, G Wakabayashi, M Mori.
Organizer
ISMRC
Place of Presentation
大阪
Related Report
-
-