| Project/Area Number |
23591943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
MITSUI Akira 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (10405178)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Takahiro 名古屋市立大学, 医学(系)研究科(研究院), 助教 (90592501)
SHIOZAKI Midori 名古屋市立大学, 医学(系)研究科(研究院), 助教 (90531004)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | lipofection / RT-PCR / western blot / 移植 / 1.lipofection |
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| Research Abstract |
In the process of studying the mechanism by which miR-128b influences the survival rate of esophageal squamous cell carcinoma (ESCC) patients, we focused on Girdin, Akt substrate which is involved in the migration of cells. In the examination of the role of Girdin in ESCC, it was suggested that Girdin is involved in the migration of ESCC as well. In experiments using specimens of ESCC, ESCC tumors whose Girdin expresson is high tends to invade deeper. In addition, the 5-year survival rate of the ESCC patients whose Girdin expression is high declined more significantly. Therefore, in ESCC, Girdin may be a prognostic marker and may serve as a therapeutic target as well.
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