| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
5-aminolevulinic acid (5-ALA) is a natural amino acid and can be converted into a photosensitizer, protoporphyrin IX (PpIX), via the heme biosynthetic pathway. Gastric cancer cell lines with 5-ALA were positive for PpIX fluorescence. After injection of 5-ALA to mouse model via the tail vein, PpIX fluorescence could be detected on metastatic lymph nodes by stereomicroscopic imaging.
A total of 144 lymph nodes obtained from 14 gastric cancer patients were examined. The patients were administered 5-ALA orally before surgery. The diagnostic results were compared to those of the routine H&E stain examination. Observed PpIX fluorescence of was identical to the metastatic lymph nodes, with 92.4 % accuracy. The area under the curve was calculated as 0.832 throughout Receiver operating characteristic (ROC) analysis.
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