| Project/Area Number |
23591948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
NEMOTO Tetsuo 東邦大学, 医学部, 准教授 (70242203)
NANAMI Tatsuki 東邦大学, 医学部, 助教 (90385831)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | SEREX / serum antibody / malignant tumor / Galectin-1 / p53 / ELISA / 胃癌 / 血清抗体 / 腫瘍マーカー / ＳＥＲＥＸ / Ｇａｌｅｃｔｉｎ-1 |
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| Outline of Final Research Achievements |
Purpose of this study was (i) establish ELISA system to detect serum anti-galectin-1 antibodies, and (ii) evaluate positive rate of serum anti- galectin-1 antibodies in patients with gastric cancer, esophageal cancer and colon cancer. Using a cut-off value of mean +3SD of serum anti- galectin-1 antibody level of healthy controls, positive rate of patients were evaluated. Overall positive rates was 9.7% in gastric cancer, 8% in esophageal cancer, and 8% in colon cancer. No clinicopathological factors were associated with presence of anti- galectin-1 antibodies.
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