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Monitoring of serum Galectin-1 antibodies during perioperative period of patients with gastric cancer

Research Project

Project/Area Number 23591948
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionToho University

Principal Investigator

YAJIMA Satoshi  東邦大学, 医学部, 助教 (00408931)

Co-Investigator(Kenkyū-buntansha) SHIMADA Hideaki  東邦大学, 医学部, 教授 (20292691)
NEMOTO Tetsuo  東邦大学, 医学部, 准教授 (70242203)
NANAMI Tatsuki  東邦大学, 医学部, 助教 (90385831)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsSEREX / serum antibody / malignant tumor / Galectin-1 / p53 / ELISA / 胃癌 / 血清抗体 / 腫瘍マーカー / SEREX / Galectin-1
Outline of Final Research Achievements

Purpose of this study was (i) establish ELISA system to detect serum anti-galectin-1 antibodies, and (ii) evaluate positive rate of serum anti- galectin-1 antibodies in patients with gastric cancer, esophageal cancer and colon cancer. Using a cut-off value of mean +3SD of serum anti- galectin-1 antibody level of healthy controls, positive rate of patients were evaluated. Overall positive rates was 9.7% in gastric cancer, 8% in esophageal cancer, and 8% in colon cancer. No clinicopathological factors were associated with presence of anti- galectin-1 antibodies.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (16 results)

  • [Journal Article] Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association.2014

    • Author(s)
      Shimada H, Noie T, Ohashi M, Oba K, Takahashi Y
    • Journal Title

      Gastric Cancer

      Volume: 17(1) Issue: 1 Pages: 26-33

    • DOI

      10.1007/s10120-013-0259-5

    • NAID

      40020215894

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 消化器癌における血清p53抗体検査の有用性.2013

    • Author(s)
      島田英昭, 谷島 聡, 船橋公彦
    • Journal Title

      Surgery Frontier

      Volume: 20(4) Pages: 106-108

    • Related Report
      2013 Research-status Report
  • [Journal Article] 5.腫瘍マーカー p53抗体2013

    • Author(s)
      大嶋陽幸, 谷島聡, 島田英昭
    • Journal Title

      臨床検査ガイド

      Volume: 41(6) Pages: 947-948

    • Related Report
      2012 Research-status Report
  • [Journal Article] Impact of serum biomarkers on esophageal squamous cell carcinoma2012

    • Author(s)
      Shimada H, Yajima S, Oshima Y, Hiwasa T, Tagawa M, Matsushita K, Nomura F
    • Journal Title

      Esophagus

      Volume: 9(3) Issue: 3 Pages: 131-140

    • DOI

      10.1007/s10388-012-0332-x

    • NAID

      40019427695

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食道癌におけるバイオマーカー 血液バイオマーカーの有用性について2011

    • Author(s)
      谷島聡, 山崎有浩, 島田英昭
    • Journal Title

      消化器外科

      Volume: 34(13) Pages: 1889-1895

    • Related Report
      2011 Research-status Report
  • [Journal Article] p53抗体はどのくらい役に立つか?2011

    • Author(s)
      谷島 聡, 大嶋陽幸, 小池淳一, 山崎有浩, 島田英昭
    • Journal Title

      成人病と生活習慣病

      Volume: 41(6) Pages: 750-752

    • Related Report
      2011 Research-status Report
  • [Presentation] (フォーラム:今、なぜ抗体マーカー?)血清IgG抗体の癌バイオマーカーとしての実用化と今後の展望.2014

    • Author(s)
      島田英昭
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 消化管癌患者におけるRalA 抗原に対する免疫反応.2014

    • Author(s)
      島田英昭, 谷島 聡, 小池淳一, 松下一之, 野村文夫, 日和佐隆樹, 田川雅敏
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早期消化器癌診断のための癌抗原特異的血清IgG抗体検出法の開発(多施設研究報告).2014

    • Author(s)
      島田英昭, 高山忠利, 河野辰幸, 村上雅彦, 北川雄光, 瀬戸泰之, 山本雅一, 矢永勝彦, 田中洋一, 金子弘真
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山市民文化センター(福島県郡山市)
    • Year and Date
      2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] StageⅡ, Ⅲ食道がんの治療効果をバイオマーカーから推測する.2014

    • Author(s)
      谷島聡, 大嶋陽幸, 名波竜規, 鈴木 隆, 伊藤正朗, 竹山照明, 澤口悠子, 根本哲生, 島田英昭, 金子弘真
    • Organizer
      第68回日本食道学会学術集会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection of serum galectin-1 antibody in gastric cancer.2011

    • Author(s)
      Yajima S, Shimada H, Yamazaki K, Oshima Y, Nanami T, Otsuka S, Washizawa N, Kaneko H
    • Organizer
      21st World Congress of the International Assocoation of Surgeons, Gastroenterologists and Oncologists (IASGO2011)
    • Place of Presentation
      KEIO PLAZA HOTEL(TOKYO)
    • Related Report
      2011 Research-status Report
  • [Presentation] Serum SEREX antibodies as new biomarkers for gastric cancer.2011

    • Author(s)
      Shimada H, Yamazaki K, Yajima S, Oshima Y, Nanami T, Tamura A, Kaneko H
    • Organizer
      9th International Gastric Cancer Congress
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] 食道扁平上皮癌症例における血清KM-HN-1抗体の検出.2011

    • Author(s)
      谷島聡, 島田英昭, 山崎有浩, 大嶋陽幸, 鈴木隆, 名波竜規, 松本悠, 田村晃, 土屋勝, 前田徹也, 大塚由一郎, 鷲澤尚宏, 石井淳, 大塚誠子, 金子弘真
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      紙上開催
    • Related Report
      2011 Research-status Report
  • [Presentation] SEREX抗原を標的とした胃癌の血清腫瘍マーカー.2011

    • Author(s)
      島田英昭, 谷島聡, 小池淳一, 田川雅敏, 竹田明彦, 松下一之, 日和佐隆樹, 野村文夫
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] Presence of serum p53IgG antibody in a patient with superficial adenocarcinoma of the esophago-gastric junction.

    • Author(s)
      Yajima S, Shiratori F, Shimada H, Kaneko H
    • Organizer
      1st International Conference of Federation of Asian Clinical Oncology (FACO)
    • Place of Presentation
      Xianmen International Conference Center (Xiamen, China)
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌診療における腫瘍マーカーCA72-4の有用性について~システマチックレビュー~.

    • Author(s)
      島田英昭, 谷島 聡, 大嶋陽幸, 名波竜規, 伊藤正朗, 船橋公彦, 鷲澤尚宏, 小池淳一, 大塚由一郎, 金子弘真
    • Organizer
      第75回日本臨床外科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ステージ4胃癌症例では腫瘍特異的血清IgG 抗体価は低下するのか?

    • Author(s)
      島田英昭, 谷島聡, 大嶋陽幸, 名波竜規, 鈴木 隆, 竹山照明, 伊藤正朗, 大塚誠子, 船橋公彦, 鷲澤尚宏, 菊池由宣, 岡住慎一, 金子弘真
    • Organizer
      第86回日本胃癌学会総会
    • Place of Presentation
      パシフィコ横浜(会議センター)(神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Are tumor markers a poor prognostic factor in preoperative patient with gastric cancer?

    • Author(s)
      Oshima Y, Shimada H, Yajima S, Nanami T, Ito M, Washizawa N, Kaneko H
    • Organizer
      10th International Gastric Cancer Congress
    • Place of Presentation
      Centro Congressi Veronafiere (Verona, Italy)
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical impact of perioperative serum p53 antibody titers in patients with esophageal carcinoma.

    • Author(s)
      Shimada H, Yajima S et al.
    • Organizer
      13th World Congress of the International Society for Diseases of the Esophagus(ISDE)
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] 消化管癌症例における血清中抗galectin-1 IgG 抗体の検出.

    • Author(s)
      谷島聡, 島田英昭
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2012 Research-status Report
  • [Presentation] SEREX 抗原(HSP70)を標的とした消化管癌症例における血清抗体診断法の開発.

    • Author(s)
      山﨑有浩、島田英昭、谷島聡
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of serum anti-galectin-1 antibody in stage I/II gastroenterological carcinomas.

    • Author(s)
      Shimada H, Yajima S et al.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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