Development of a new fluorescence imaging system for peritoneal and lymph node metastasis of GI tract cancers
Project/Area Number |
23591952
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Aichi Cancer Center Research Institute |
Principal Investigator |
ITO Yuichi 愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (80397463)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 蛍光イメージング / 腹腔鏡 / ICG近赤外蛍光 / 腹膜転移 / リンパ節転移 / 抗体プローブ / ICG蛍光 / リンパ節高転移 / 光イメージング / 分子イメージング / 胃がん・大腸がん |
Research Abstract |
Peritoneal and lymph node metastasis is the most frequent pattern of recurrence after curative surgery for gastric cancer. However, such a recurrence is difficult to detect by conventional CT and MRI at an early stage. In the present study, we first developed a new lymph node metastasis model using GFP-tagged tumor cells. Second, we developed a new laparoscopic fluorescence device for detecting metastasis using ICG-labeled antibody as a probe. Using these mouse metastasis model and imaging device, we successfully detected peritoneal metastasis and lymph node metastasis at an early stage with high sensitivity and specificity.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Induction of a pathological complete response by four courses of neoadjuvant chemotherapy for gastric cancer: early results of the randomized phase II COMPASS trial2014
Author(s)
Yoshikawa T, Tanabe K, Nishikawa K, Ito Y, Matsui T, Kimura Y, Hirabayashi N, Mikata S, Iwahashi M, Fukushima R, Takiguchi N, Miyashiro I, Morita S, Miyashita Y, Tsuburaya A, Sakamoto J.
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Journal Title
Annals of Surgical Oncology
Volume: 21
Issue: 1
Pages: 213-219
DOI
Related Report
Peer Reviewed
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[Journal Article] Accuracy of CT Staging of Locally Advanced Gastric Cancer after Neoadjuvant Chemotherapy: Cohort Evaluation within a Randomized Phase II Study.2014
Author(s)
Yoshikawa T, Tanabe K, Nishikawa K, Ito Y, Matsui T, Kimura Y, Hasegawa S, Aoyama T, Hayashi T, Morita S, Miyashita Y, Tsuburaya A, Sakamoto J.
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Journal Title
Annals of Surgical Oncology
Volume: 21
Issue: S3
Pages: 385-389
DOI
Related Report
Peer Reviewed
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[Presentation] 光イメージングとMRIを融合した胃癌腹膜転移に対するMultimodalityイメージング
Author(s)
伊藤友一, 中西 速夫, 伊藤 誠二, 三澤 一成, 植村 則久, 木村 賢哉, 千田 嘉毅, 安部 哲也, 小森 康司, 金光 幸秀, 佐野 力, 清水 泰博, 木下 平
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
国立京都国際会館(京都)
Related Report
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[Presentation] 食道・胃外科領域の手術法の工夫 腹腔鏡下胃全摘(LATG)術後の再建法 Endo-Stichを用いた食道 空腸吻合とY脚空腸パウチ作成
Author(s)
伊藤友一, 三澤 一成, 伊藤 誠二, 川合 亮佑, 植村 則久, 木下 敬史, 木村 賢哉, 千田 嘉毅, 安部 哲也, 小森 康司, 佐野 力, 清水 泰博, 木下 平
Organizer
第26回日本内視鏡外科学会総会
Place of Presentation
福岡国際会議場(福岡)
Related Report
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