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The combination therapy of the cancer-vaccine therapy and the preoperative chemoradiotherapy for rectal cancer (phase I trial)

Research Project

Project/Area Number 23591954
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

TSURITA Giichiro  東京大学, 医科学研究所, 講師 (80345206)

Co-Investigator(Kenkyū-buntansha) SHINOZAKI Masaru  東京大学, 医科学研究所, 准教授 (10312315)
HATA Keisuke  東京大学, 医科学研究所, 助教 (60526755)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords直腸癌 / 術前放射線化学療法 / 癌ペプチド / 腫瘍特異的ワクチン療法 / 臨床試験 / 免疫療法
Research Abstract

This study was a phase I clinical trial of the therapy, combined preoperative chemoradiotherapy with tumor-specific vaccine therapy, for the cases with advanced rectal cancer. The purpose of this study was to examine the safety of this combination therapy. Unfortunately, this clinical trial, however the protocol of this clinical trial or the document of informed consent was prepared in the first year, was not able to be performed within research periods.
It was useful, however, in performing this clinical trial in future, to analyze the data of the advanced rectal cancer cases performed preoperative chemoradiotherapy, or to locate and educate not only medical doctors but also nurses, pharmacists, and medical technicians for this study.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (6 results)

  • [Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer2014

    • Author(s)
      Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y.
    • Journal Title

      PLoS One

      Volume: 9(1)

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of family history of gastric cancer on colorectal neoplasias in young Japanese2013

    • Author(s)
      Hata K, Shinozaki M, Toyoshima O, Toyoshima A, Matsumoto S, Saisho T, Tsurita G.
    • Journal Title

      Colorectal Dis.

      Volume: 15(1) Pages: 42-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Case of secondary syphilis presenting with unusual complications : syphilitic proctitis, gastritis, and hepatitis2011

    • Author(s)
      Adachi E, Koibuchi T, Okame M, Sato H, Imai K, Shimizu S, Tsurita G, Oyaizu N, Iwamoto A, Fujii T.
    • Journal Title

      J Clin Microbiol

      Volume: 49(12) Pages: 4394-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is surveillance endoscopy necessary after colectomy in ulcerative colitis?2011

    • Author(s)
      Shuno Y, Hata K, Sunami E, Shinozaki M, Kawai K, Kojima T, Tsurita G, Hiyoshi M, Tsuno NH, Kitayama J, Nagawa H.
    • Journal Title

      ISRN Gastroenterol

      Volume: 2011 Pages: 1-4

    • DOI

      10.5402/2011/509251

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 分子腫瘍マーカー‐治療経過と経過指標として2011

    • Author(s)
      釣田義一郎,水野靖大,畑啓介,篠崎大,今井浩三
    • Journal Title

      Current Therapy

      Volume: 29(12) Pages: 1104-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] 分子腫瘍マーカー-治療経過と経過指標として2011

    • Author(s)
      釣田義一郎,水野靖大,畑啓介,篠崎大,今井浩三
    • Journal Title

      Current Therapy

      Volume: 29 (12) Pages: 1104-1108

    • Related Report
      2011 Research-status Report
  • [Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer

    • Author(s)
      Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y.
    • Journal Title

      PLoS One

      Volume: 9(1)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 治癒切除不能大腸癌に対する積極的集学的治療の有効性についての検討2014

    • Author(s)
      釣田義一郎,谷澤健太郎,吉岡佑一郎,篠崎大
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 標準治療が無効と判断された再発直腸癌に対してFOLFOX療法をやり直したところ長期生存が得られた1例2013

    • Author(s)
      釣田義一郎,畑啓介,谷澤健太郎,篠崎大
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎
    • Year and Date
      2013-07-18
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] The therapeutic strategy of the stage IV colorectal cancer2012

    • Author(s)
      Tsurita G, Shinozaki M, Hata K.
    • Organizer
      XXV Biennial Congress of the International Society of University Colon & Rectal Surgeons
    • Place of Presentation
      Bologna
    • Year and Date
      2012-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] The Therapeutic Strategy of the Stage IV Colorectal Cancer2012

    • Author(s)
      Tsurita G, Shinozaki M, Hata K
    • Organizer
      XXV Biennial Congress of the International Society of University Colon & Rectal Surgeons
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] StageIV大腸癌の治療戦略2011

    • Author(s)
      釣田義一郎,篠崎大,水野靖大,畑啓介
    • Organizer
      第75回大腸癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Stage IV大腸癌の治療成績2011

    • Author(s)
      釣田義一郎,篠崎大,水野靖大,畑啓介
    • Organizer
      第75回大腸癌研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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