The combination therapy of the cancer-vaccine therapy and the preoperative chemoradiotherapy for rectal cancer (phase I trial)
| Project/Area Number |
23591954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINOZAKI Masaru 東京大学, 医科学研究所, 准教授 (10312315)
HATA Keisuke 東京大学, 医科学研究所, 助教 (60526755)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 直腸癌 / 術前放射線化学療法 / 癌ペプチド / 腫瘍特異的ワクチン療法 / 臨床試験 / 免疫療法 |
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| Research Abstract |
This study was a phase I clinical trial of the therapy, combined preoperative chemoradiotherapy with tumor-specific vaccine therapy, for the cases with advanced rectal cancer. The purpose of this study was to examine the safety of this combination therapy. Unfortunately, this clinical trial, however the protocol of this clinical trial or the document of informed consent was prepared in the first year, was not able to be performed within research periods.
It was useful, however, in performing this clinical trial in future, to analyze the data of the advanced rectal cancer cases performed preoperative chemoradiotherapy, or to locate and educate not only medical doctors but also nurses, pharmacists, and medical technicians for this study.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer2014
Author(s)
Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Case of secondary syphilis presenting with unusual complications : syphilitic proctitis, gastritis, and hepatitis2011
Author(s)
Adachi E, Koibuchi T, Okame M, Sato H, Imai K, Shimizu S, Tsurita G, Oyaizu N, Iwamoto A, Fujii T.
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Journal Title
J Clin Microbiol
Volume: 49(12)
Pages: 4394-6
Related Report
Peer Reviewed
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[Journal Article] Is surveillance endoscopy necessary after colectomy in ulcerative colitis?2011
Author(s)
Shuno Y, Hata K, Sunami E, Shinozaki M, Kawai K, Kojima T, Tsurita G, Hiyoshi M, Tsuno NH, Kitayama J, Nagawa H.
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Journal Title
DOI
Related Report
Peer Reviewed
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[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer
Author(s)
Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y.
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Journal Title
Related Report
Peer Reviewed
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