CXCR4-CXCL12 signaling pathway is an important biological mediator in colorectal cancer cells
| Project/Area Number |
23591957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOI Takanori 福井大学, 医学部附属病院, 講師 (60225638)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 大腸癌 / ケモカイン / ケモカインレセプター / 浸潤 / 転移 / CXCR4 / CXCL12 |
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| Research Abstract |
We examined the effect and mechanism of CXCR4-CXCL12 signaling pathway in colorectal cancer cells. The CXCR4-CXCL12 system plays a role for proliferation, invasion, and tube formation of CXCR4-expressing colorectal cancer cells. Anticancer drug: 5FU inhibited proliferation and invasion activity of the colorectal cancer cells through down-regulation of CXCR4 expression. The CXCR4-CXCL12 signaling is an important biological mediator of colorectal cancer cells, suggesting that it is an important factor for the function of metastatic activity.
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Report
(4 results)
Research Products
(14 results)
