| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We examined the effect and mechanism of CXCR4-CXCL12 signaling pathway in colorectal cancer cells. The CXCR4-CXCL12 system plays a role for proliferation, invasion, and tube formation of CXCR4-expressing colorectal cancer cells. Anticancer drug: 5FU inhibited proliferation and invasion activity of the colorectal cancer cells through down-regulation of CXCR4 expression. The CXCR4-CXCL12 signaling is an important biological mediator of colorectal cancer cells, suggesting that it is an important factor for the function of metastatic activity.
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