New method for ulcerative colitis associated cancer
Project/Area Number |
23591960
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Mie University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KUSUNOKI Masato 三重大学, 大学院医学系研究科, 教授 (50192026)
YOSHIYAMA Shigeyuki 三重大学, 医学部附属病院, 診療従事者 (60444436)
OKITA Yoshiki 三重大学, 医学部, 助教 (20378342)
MIKI Chikao 三重大学, 大学院医学系研究科, 客員教授 (50242962)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
Keywords | 小腸大腸肛門外科学 / 潰瘍性大腸炎 / 大腸癌 / 異形成 / 一酸化窒素 / 酸化 / 炎症性発癌 |
Research Abstract |
To clarify whether the expression of nitrative and oxidative DNA damage markers in the rectal mucosa of patients with ulcerative colitis (UC) could be used to predict UC-associated neoplasia. A total of 141 patients with UC who underwent a proctocolectomy were enrolled in this study. The expression of 8-nitroguanine (8-NG), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), and inducible nitric oxide synthase (iNOS) in the rectal mucosa were evaluated using immunohistochemistry (IHC) and assessed relative to the pathogenesis of UC-associated neoplasia. The results suggest that evaluating the expression levels of 8-NG in the rectal mucosa may be a useful biomarker for detecting patients with UC-associated neoplasia.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Identification of patients with developing ulcerative colitis-associated neoplasia by nitrative DNA damage marker 8-nitroguanin expression in rectal mucosa2013
Author(s)
Saigusa S, Araki T, Tanaka K, Hashimoto K, Okita Y, Fujikawa H, Okugawa Y, Toiyama Y, Inoue Y, Uchida K, Mohri Y, Kusunoki M.
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Journal Title
J Clin Gastroenterol
Volume: 47
Related Report
Peer Reviewed
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[Journal Article] Identification of patients with developing ulcerative colitis-associated neoplasia by nitrative DNA damage marker 8-nitroguanin expression in rectal mucosa.2013
Author(s)
Saigusa S, Araki T, Tanaka K, Hashimoto K, Okita Y, Fujikawa H, Okugawa Y, Toiyama Y, Inoue Y, Uchida K, Mohri Y, Kusunoki M.
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Journal Title
J Clin Gastroenterol
Volume: 47
Issue: 9
Pages: e80-e86
DOI
Related Report
Peer Reviewed
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[Presentation] 一酸化窒素の発癌機構に着目したcolitic cancer早期診断アプローチ2012
Author(s)
荒木俊光, 三枝晋, 橋本清, 大北喜基, 藤川裕之, 奥川喜永, 川村幹雄, 廣純一郎, 田中光司, 井上靖浩, 内田恵一, 毛利靖彦, 楠正人
Organizer
第67回日本大腸肛門病学会学術集会
Place of Presentation
福岡
Year and Date
2012-11-17
Related Report