| Project/Area Number |
23591962
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
TAKEMASA Ichiro 大阪大学, 医学(系)研究科(研究院), 助教 (50379252)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIZUSHIMA Tunekazu 大阪大学, 附属病院消化器外, 講師 (00527707)
IKEDA Masataka 独立行政法人国立病院機構大阪医療センター, 外科, 研究員 (80335356)
YAMAMOTO Hirofumi 大阪大学, 附属病院消化器外, 准教授 (30322184)
SEKIMOTO Mithugu 独立行政法人国立病院機構大阪医療センター, 外科, 研究員 (10273658)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 大腸癌 / 予後・治療応答性 / 予測診断 / 臨床応用 / パスウェイ / 大腸がん / 遺伝子発現プロファイル / 予後予測 / 個別化医療 / 予後診断用臨床チップ / 癌の多様性 / 薬剤感受性 |
|---|
| Research Abstract |
We have been attempting to stratify curatively resected colorectal cancer(CRC) into good or poor prognoses based on gene expression signatures.Using the clinical DNA chip,we attempted to select discriminator genes,with the 150 retrospective CRC sample set,resulting 55 markers.We then applied the discriminator set to the second,150 CRC samples set in a prospective sample set for predictive accuracy and prognostic validity.Kaplan-Meyer analysis showed a significant difference between the"good signature group(low-risk)"and the "poor signature group (high risk)" (Log-rank p equal 0.0019).The multivariate Cox analyses showed the significant parameters to predict the prognosis with a hazard ratio of 3.5(95 persent confidence interval, 0.12-0.67 p=0.004). this personalized prognosis is crucial with CRC patients, the predictive performance may deserve serious consideration for possible application to clinic.
|
