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HMGB1 is a new immunological biomarker for prognosis in patients with digestive cancer.

Research Project

Project/Area Number 23591963
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionYamaguchi University

Principal Investigator

SUZUKI Nobuaki  山口大学, 医学(系)研究科(研究院), 助教 (50526910)

Co-Investigator(Kenkyū-buntansha) YOSHIMURA Kiyoshi  山口大学, 医学部附属病院, 助教 (30346564)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsHMGB1 / バイオマーカー / NKG2D / ULBP1 / B7-H3 / NKG2DL / Toll like receptor / 化学療法 / 免疫療法 / Toll like recepter
Research Abstract

High mobility group box 1 (HMGB1) plays a role in many clinical conditions such as autoimmunity, acute ischemia-reperfusion injury, cardiovascular disease and cancer. HMGB1 is a nuclear protein and released from the apoptotic cells to activate cytotoxic T cells and antigen-presenting cells effectively. The aim of this study was to clarify HMGB1 is associated with recurrence or prognosis as a biomarker, and we performed immunohistochemistry of HMGB1 in resected specimen. We performed immunohistochemistry for 90 gastric cancer cases, 30 cases of colorectal cancer, and 10 cases as pancreatic cancer, the expression of HMGB1 in cancer tissues is a good prognostic factor in gastric cancer patients. B7-H3, NKG2D, NKG2DL are also stained, with a combination of expression of staining intensity, ULBP1/NKG2D interaction was suggested as good prognostic marker for the patients in gastric cancer.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013

All Presentation (6 results)

  • [Presentation] 胃癌に対する新規免疫学的バイオマーカーとしてのHigh Mobility Group Box 1の有用性2013

    • Author(s)
      鈴木伸明
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部(山口)
    • Related Report
      2013 Final Research Report
  • [Presentation] 胃癌に対するHigh Mobility Group Box 1の新規免疫学的バイオマーカー2013

    • Author(s)
      鈴木伸明、吉村清
    • Organizer
      第85回日本胃癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Final Research Report
  • [Presentation] Expressions of NKG2D ligand/NKG2D are related to their clinicopathological outcome in patients with gastric cancer2013

    • Author(s)
      Kiyoshi Yoshimura, Nobuaki Suzuki
    • Organizer
      第85回日本胃癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Final Research Report
  • [Presentation] 胃癌に対する新規免疫学的バイオマーカーとしてのHigh Mobility Group Box 1の有用性2013

    • Author(s)
      鈴木伸明
    • Organizer
      日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部(山口県宇部市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胃癌に対するHigh Mobility Group Box 1の新規免疫学的バイオマーカー2013

    • Author(s)
      鈴木伸明、吉村 清
    • Organizer
      第85回胃癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] Expressions of NKG2D ligand/NKG2D are related to their clinicopathological outcome in patients with gastric cancer2013

    • Author(s)
      Kiyoshi Yoshimura, Nobuaki Suauki
    • Organizer
      第85回胃癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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