| Project/Area Number |
23591964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
KOHNOE Shunji 九州大学, 医学(系)研究科(研究院), 共同研究員 (30215199)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJITANI Shunichi 九州大学, 医学研究院, 准教授 (30188544)
KAKEJI Yoshihiro 神戸大学, 医学研究科, 教授 (80284488)
MORITA Masaru 九州大学, 医学研究院, 准教授 (30294937)
OHGA Takefumi 九州大学, 大学病院, 助教 (60335958)
EGASHIRA Akinori 九州大学, 大学病院, 特任助教 (00419524)
SONODA Hideto 九州大学, 大学病院, 特任助教 (00465725)
KITAO Hiroyuki 九州大学, 医学研究院, 准教授 (30368617)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 大腸癌 / ゲノム不安定性 / 染色体不安定性 / スピンドルチェックポイント / DNA aneuploidy / BUBR1 / Aurora-A / Aurora-B / PLK1 / 発がん |
|---|
| Research Abstract |
In order to elucidate the molecular abnormality in colorectal carcinogenesis, we investigate the disorders in the spindle assembly checkpoint genes by examining those expressions in colorectal cancer cell. Our data showed that p53 gene mutation (loss of normal function) might induce suppression of spindle assembly checkpoint genes, and might contribute to DNA aneuploidy and thereafter carcinogenesis.
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