| Project/Area Number |
23591967
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITANO Seigou 大分大学, 法人本部, 学長 (90169871)
MORIYAMA Masatsugu 大分大学, 医学部, 教授 (90239707)
NOGUCHI Takayuki 大分大学, 医学部, 病院長 (90156183)
ETOH Tsuyoshi 大分大学, 医学部, 講師 (00404369)
HIRATSUKA Takahiro 大分大学, 医学部, 医員 (20600886)
萩原 聡 大分大学, 医学部, 講師 (50527661)
緒方 一美 大分大学, 医学部, 研究員 (70596048)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 小腸大腸肛門外科学 / 腫瘍学 / 抗酸化剤 / オートファジー / 腫瘍増殖 / 腹膜播種 / アポトーシス / 胃癌 |
|---|
| Research Abstract |
We investigated whether new antioxidants, alfa-lipoic acid (ALA) delivertives and vitamin E delivertives elicits its antiproliferative effects in vivo and in vitro by inducing apoptosis, autophagy or cell cycle arrest, and we analyzed the expression of proteins related to these phenomena and their phosphorylation in HT-29 human colon cancer cells. These new antioxidants inhibited the proliferation of HT-29 cells through the mechanisms of G2/M cell cycle arrest and autophagy but not that of apoptosis. The newly synthesized ALA derivative may be expected to become a novel cancer therapeutic strategy through its induction of autophagy.
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